A Brief Mindfulness Program Did Not Help People With Cannabis Use Disorder Reduce Their Use

A randomized trial of 66 adults with cannabis use disorder found that a brief mindfulness-based intervention did not reduce cannabis frequency, quantity, or cravings compared to relaxation or control conditions.

Lorenzetti, Valentina et al.·Drug and alcohol dependence·2025·Moderate EvidenceRandomized Controlled Trial
RTHC-06986Randomized Controlled TrialModerate Evidence2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Randomized Controlled Trial
Evidence
Moderate Evidence
Sample
N=23

What This Study Found

There were no significant intervention-by-time effects on the primary outcome of cannabis use frequency, nor on secondary outcomes including quantity, cravings, relaxation, or mindfulness scores. The null findings held across all three conditions (mindfulness, relaxation, control) over the approximately 16-day intervention period.

Key Numbers

66 participants (19 female), ages 18-56. Three groups: MBI (23), relaxation (21), control (22). Mean intervention duration: 16 days. Primary outcome (cannabis frequency): F=0.26, FDR-adjusted p=0.86 (no significant effect). No significant effects on any secondary outcome.

How They Did This

Pre-registered, double-blind RCT of 66 adults (ages 18-56) with cannabis use disorder who had attempted to cut down in the past 2 years. Participants were randomized 1:1:1 to mindfulness-based intervention (n=23), relaxation (n=21), or control (n=22). All conditions included daily monitoring. Mean intervention duration: 16 days.

Why This Research Matters

Brief, scalable interventions for cannabis use disorder are urgently needed. This well-designed trial shows that a short mindfulness program alone is not sufficient, suggesting more intensive or differently designed interventions may be necessary.

The Bigger Picture

While mindfulness shows promise for various substance use disorders, this study suggests that brief, self-directed mindfulness programs may not be intensive enough for cannabis use disorder. It may need to be combined with other approaches or delivered over a longer period.

What This Study Doesn't Tell Us

Small sample (66). Brief intervention (~16 days) may be too short. Online delivery may reduce engagement. All conditions included daily monitoring, which itself could affect cannabis use. Recruitment during COVID-19 (2019-2022) may have influenced results.

Questions This Raises

  • ?Would a longer or more intensive mindfulness program show different results?
  • ?Could mindfulness work as an adjunct to other CUD treatments?
  • ?Does the daily monitoring in all groups create a "treatment effect" that masks differences?

Trust & Context

Key Stat:
No significant effects on cannabis frequency, quantity, or cravings across all three conditions
Evidence Grade:
Moderate: pre-registered, double-blind RCT with appropriate controls, though small sample and brief intervention limit conclusions.
Study Age:
2025 study (recruitment 2019-2022).
Original Title:
Brief mindfulness intervention for adults with cannabis use disorder: A randomised clinical trial.
Published In:
Drug and alcohol dependence, 277, 112909 (2025)
Database ID:
RTHC-06986

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled TrialGold standard for testing treatments
This study
Cohort / Case-Control
Cross-Sectional / Observational
Case Report / Animal Study

Participants are randomly assigned to treatment or placebo groups to test cause and effect.

What do these levels mean? →

Frequently Asked Questions

Does mindfulness help with cannabis use disorder?

This brief program did not. A ~16-day mindfulness intervention showed no benefit over relaxation or monitoring alone for reducing cannabis use, quantity, or cravings.

Should people with CUD still try mindfulness?

This study tested a brief, self-directed program. More intensive mindfulness-based therapies or mindfulness combined with other treatments might still be effective and have not been ruled out.

Read More on RethinkTHC

Cite This Study

RTHC-06986·https://rethinkthc.com/research/RTHC-06986

APA

Lorenzetti, Valentina; McTavish, Eugene; Thomson, Hannah; Clemente, Adam; Rendell, Peter; Terrett, Gill; Greenwood, Lisa-Marie; Freeman, Tom P; Kamboj, Sunjeev K; Manning, Victoria. (2025). Brief mindfulness intervention for adults with cannabis use disorder: A randomised clinical trial.. Drug and alcohol dependence, 277, 112909. https://doi.org/10.1016/j.drugalcdep.2025.112909

MLA

Lorenzetti, Valentina, et al. "Brief mindfulness intervention for adults with cannabis use disorder: A randomised clinical trial.." Drug and alcohol dependence, 2025. https://doi.org/10.1016/j.drugalcdep.2025.112909

RethinkTHC

RethinkTHC Research Database. "Brief mindfulness intervention for adults with cannabis use ..." RTHC-06986. Retrieved from https://rethinkthc.com/research/lorenzetti-2025-brief-mindfulness-intervention-for

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.