A Brief Mindfulness Program Did Not Help People With Cannabis Use Disorder Reduce Their Use
A randomized trial of 66 adults with cannabis use disorder found that a brief mindfulness-based intervention did not reduce cannabis frequency, quantity, or cravings compared to relaxation or control conditions.
Quick Facts
What This Study Found
There were no significant intervention-by-time effects on the primary outcome of cannabis use frequency, nor on secondary outcomes including quantity, cravings, relaxation, or mindfulness scores. The null findings held across all three conditions (mindfulness, relaxation, control) over the approximately 16-day intervention period.
Key Numbers
66 participants (19 female), ages 18-56. Three groups: MBI (23), relaxation (21), control (22). Mean intervention duration: 16 days. Primary outcome (cannabis frequency): F=0.26, FDR-adjusted p=0.86 (no significant effect). No significant effects on any secondary outcome.
How They Did This
Pre-registered, double-blind RCT of 66 adults (ages 18-56) with cannabis use disorder who had attempted to cut down in the past 2 years. Participants were randomized 1:1:1 to mindfulness-based intervention (n=23), relaxation (n=21), or control (n=22). All conditions included daily monitoring. Mean intervention duration: 16 days.
Why This Research Matters
Brief, scalable interventions for cannabis use disorder are urgently needed. This well-designed trial shows that a short mindfulness program alone is not sufficient, suggesting more intensive or differently designed interventions may be necessary.
The Bigger Picture
While mindfulness shows promise for various substance use disorders, this study suggests that brief, self-directed mindfulness programs may not be intensive enough for cannabis use disorder. It may need to be combined with other approaches or delivered over a longer period.
What This Study Doesn't Tell Us
Small sample (66). Brief intervention (~16 days) may be too short. Online delivery may reduce engagement. All conditions included daily monitoring, which itself could affect cannabis use. Recruitment during COVID-19 (2019-2022) may have influenced results.
Questions This Raises
- ?Would a longer or more intensive mindfulness program show different results?
- ?Could mindfulness work as an adjunct to other CUD treatments?
- ?Does the daily monitoring in all groups create a "treatment effect" that masks differences?
Trust & Context
- Key Stat:
- No significant effects on cannabis frequency, quantity, or cravings across all three conditions
- Evidence Grade:
- Moderate: pre-registered, double-blind RCT with appropriate controls, though small sample and brief intervention limit conclusions.
- Study Age:
- 2025 study (recruitment 2019-2022).
- Original Title:
- Brief mindfulness intervention for adults with cannabis use disorder: A randomised clinical trial.
- Published In:
- Drug and alcohol dependence, 277, 112909 (2025)
- Authors:
- Lorenzetti, Valentina(15), McTavish, Eugene(5), Thomson, Hannah(4), Clemente, Adam, Rendell, Peter, Terrett, Gill, Greenwood, Lisa-Marie, Freeman, Tom P, Kamboj, Sunjeev K, Manning, Victoria
- Database ID:
- RTHC-06986
Evidence Hierarchy
Participants are randomly assigned to treatment or placebo groups to test cause and effect.
What do these levels mean? →Frequently Asked Questions
Does mindfulness help with cannabis use disorder?
This brief program did not. A ~16-day mindfulness intervention showed no benefit over relaxation or monitoring alone for reducing cannabis use, quantity, or cravings.
Should people with CUD still try mindfulness?
This study tested a brief, self-directed program. More intensive mindfulness-based therapies or mindfulness combined with other treatments might still be effective and have not been ruled out.
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Cite This Study
https://rethinkthc.com/research/RTHC-06986APA
Lorenzetti, Valentina; McTavish, Eugene; Thomson, Hannah; Clemente, Adam; Rendell, Peter; Terrett, Gill; Greenwood, Lisa-Marie; Freeman, Tom P; Kamboj, Sunjeev K; Manning, Victoria. (2025). Brief mindfulness intervention for adults with cannabis use disorder: A randomised clinical trial.. Drug and alcohol dependence, 277, 112909. https://doi.org/10.1016/j.drugalcdep.2025.112909
MLA
Lorenzetti, Valentina, et al. "Brief mindfulness intervention for adults with cannabis use disorder: A randomised clinical trial.." Drug and alcohol dependence, 2025. https://doi.org/10.1016/j.drugalcdep.2025.112909
RethinkTHC
RethinkTHC Research Database. "Brief mindfulness intervention for adults with cannabis use ..." RTHC-06986. Retrieved from https://rethinkthc.com/research/lorenzetti-2025-brief-mindfulness-intervention-for
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.