Addressing tobacco use during cannabis treatment is feasible but tobacco quit rates remain poor

Simultaneously treating tobacco use during cannabis treatment was acceptable and did not undermine cannabis outcomes, but tobacco cessation rates were low regardless of timing.

Lee, Dustin C et al.·Journal of substance abuse treatment·2019·Preliminary EvidenceRandomized Controlled Trial
RTHC-02131Randomized Controlled TrialPreliminary Evidence2019RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Randomized Controlled Trial
Evidence
Preliminary Evidence
Sample
N=67

What This Study Found

No significant differences in cannabis outcomes between simultaneous and sequential tobacco treatment during weeks 1-12. Most simultaneous participants engaged with the tobacco intervention (62% initiated counseling, 50% made quit attempts). However, only 30% of sequential participants continued to the delayed tobacco phase, highlighting the risk of deferring treatment.

Key Numbers

67 adults enrolled; SIM: 62% initiated tobacco counseling, 50% made quit attempts, 41% used NRT; SEQ: 39% made quit attempts spontaneously before tobacco phase began; only 30% of SEQ continued to weeks 13-24.

How They Did This

Proof-of-concept RCT with 67 adults receiving simultaneous (SIM) or sequential (SEQ) tobacco cessation during outpatient cannabis use disorder treatment. SIM received tobacco intervention weeks 1-12; SEQ received it weeks 13-24. Both included web-based counseling plus nicotine replacement therapy.

Why This Research Matters

Tobacco use is common among people seeking cannabis treatment and predicts worse cannabis outcomes. Clinicians often hesitate to address both substances simultaneously, but this study suggests that concern may be unfounded.

The Bigger Picture

The finding that 39% of sequential participants spontaneously attempted tobacco cessation before it was offered suggests patients are motivated to address tobacco when they are already working on cannabis. Delaying the intervention may miss this window.

What This Study Doesn't Tell Us

Small sample (67), proof-of-concept design. High attrition in the sequential arm compromised comparison. Tobacco cessation outcomes were poor in both groups. Single-site study.

Questions This Raises

  • ?Would more intensive tobacco interventions produce better quit rates in this population?
  • ?Does quitting tobacco actually improve long-term cannabis outcomes?

Trust & Context

Key Stat:
62% engaged with tobacco treatment
Evidence Grade:
Preliminary: small proof-of-concept trial with high attrition in one arm.
Study Age:
Published in 2019.
Original Title:
Sequential and simultaneous treatment approaches to cannabis use disorder and tobacco use.
Published In:
Journal of substance abuse treatment, 98, 39-46 (2019)
Database ID:
RTHC-02131

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled TrialGold standard for testing treatments
This study
Cohort / Case-Control
Cross-Sectional / Observational
Case Report / Animal Study

Participants are randomly assigned to treatment or placebo groups to test cause and effect.

What do these levels mean? →

Frequently Asked Questions

Should tobacco treatment wait until after cannabis treatment?

This study suggests not. Delaying tobacco treatment led to 70% dropout before it could be offered, while simultaneous treatment did not harm cannabis outcomes.

Did addressing tobacco hurt cannabis treatment?

No. There were no significant differences in cannabis outcomes between the groups during the first 12 weeks.

Read More on RethinkTHC

Cite This Study

RTHC-02131·https://rethinkthc.com/research/RTHC-02131

APA

Lee, Dustin C; Walker, Denise D; Hughes, John R; Brunette, Mary F; Scherer, Emily; Stanger, Catherine; Etter, Jean-Francois; Auty, Samantha; Budney, Alan J. (2019). Sequential and simultaneous treatment approaches to cannabis use disorder and tobacco use.. Journal of substance abuse treatment, 98, 39-46. https://doi.org/10.1016/j.jsat.2018.12.005

MLA

Lee, Dustin C, et al. "Sequential and simultaneous treatment approaches to cannabis use disorder and tobacco use.." Journal of substance abuse treatment, 2019. https://doi.org/10.1016/j.jsat.2018.12.005

RethinkTHC

RethinkTHC Research Database. "Sequential and simultaneous treatment approaches to cannabis..." RTHC-02131. Retrieved from https://rethinkthc.com/research/lee-2019-sequential-and-simultaneous-treatment

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.