Cannabis Users Who Try to Quit Smoking Increase Their Cannabis Use as Compensation

In a smoking cessation trial of 392 Black adults, the 47% who also used cannabis increased their cannabis consumption through week 26 while reducing cigarettes at similar rates to non-cannabis users, suggesting a compensatory pattern.

Lambart, Leah M et al.·Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco·2025·Moderate EvidenceRandomized Controlled Trial
RTHC-06890Randomized Controlled TrialModerate Evidence2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Randomized Controlled Trial
Evidence
Moderate Evidence
Sample
N=392

What This Study Found

47.2% of participants were cigarette-cannabis dual users. Both groups reduced cigarettes similarly (p=0.18 for group difference). Cannabis users increased their cannabis consumption through week 26 (p<0.001). When cigarettes decreased, other tobacco products increased as compensation (p<0.0001), but cannabis did not follow the same compensatory pattern (p=0.37). Cannabis users maintained higher other tobacco product use throughout.

Key Numbers

392 participants; 47.2% dual CIG-CAN users; cannabis use increased through week 26 (p<0.001); CPD reduction similar between groups; OTP showed compensatory increase (p<0.0001).

How They Did This

Secondary analysis of an 18-week smoking cessation RCT with 26-week follow-up. 392 Black adults wanting to quit cigarettes. Standard or adapted pharmacotherapy. Self-reported cigarettes, cannabis, and other tobacco use at weeks 0, 2, 6, 12, 18, 26.

Why This Research Matters

Nearly half of Black adults attempting to quit smoking also use cannabis, yet cannabis use is rarely addressed in cessation programs. The increase in cannabis use during a quit attempt may undermine the health benefits of reducing cigarettes.

The Bigger Picture

Smoking cessation interventions typically ignore concurrent cannabis use. This study suggests that for the large proportion of smokers who also use cannabis, a cigarette-only approach may shift consumption patterns rather than reduce overall harm.

What This Study Doesn't Tell Us

Secondary analysis, not prospectively designed for cannabis outcomes. Self-reported data. Predominantly Black adult sample may not generalize. Cannabis quantity not precisely measured. Cannot determine if cannabis increase is causal compensation.

Questions This Raises

  • ?Should smoking cessation programs routinely address concurrent cannabis use?
  • ?Does the cannabis increase during quit attempts offset the health benefits of cigarette reduction?

Trust & Context

Key Stat:
47% of smoking cessation participants also used cannabis
Evidence Grade:
Secondary analysis of a well-designed RCT provides useful data, but not prospectively designed for cannabis outcomes.
Study Age:
2025 secondary analysis of a smoking cessation RCT (NCT03897439).
Original Title:
Change in Cigarette, Other Tobacco Product, and Cannabis Use Among Individuals Who Used or Did Not Use Cannabis During a Smoking Cessation Trial.
Published In:
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 27(9), 1641-1646 (2025)
Database ID:
RTHC-06890

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled TrialGold standard for testing treatments
This study
Cohort / Case-Control
Cross-Sectional / Observational
Case Report / Animal Study

Participants are randomly assigned to treatment or placebo groups to test cause and effect.

What do these levels mean? →

Frequently Asked Questions

Do people smoke more cannabis when trying to quit cigarettes?

In this trial, dual cigarette-cannabis users increased their cannabis consumption through 26 weeks while successfully reducing cigarettes, suggesting a compensatory pattern.

Should quit-smoking programs address cannabis use?

This study suggests yes. Nearly half of participants used cannabis, and the increase in cannabis during the quit attempt may limit the health benefits of cigarette reduction.

Read More on RethinkTHC

Cite This Study

RTHC-06890·https://rethinkthc.com/research/RTHC-06890

APA

Lambart, Leah M; Cox, Lisa Sanderson; Mayo, Matthew S; Brown, Alexandra R; Leavens, Eleanor L S; Ahluwalia, Jasjit S; Nollen, Nicole L. (2025). Change in Cigarette, Other Tobacco Product, and Cannabis Use Among Individuals Who Used or Did Not Use Cannabis During a Smoking Cessation Trial.. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 27(9), 1641-1646. https://doi.org/10.1093/ntr/ntaf045

MLA

Lambart, Leah M, et al. "Change in Cigarette, Other Tobacco Product, and Cannabis Use Among Individuals Who Used or Did Not Use Cannabis During a Smoking Cessation Trial.." Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2025. https://doi.org/10.1093/ntr/ntaf045

RethinkTHC

RethinkTHC Research Database. "Change in Cigarette, Other Tobacco Product, and Cannabis Use..." RTHC-06890. Retrieved from https://rethinkthc.com/research/lambart-2025-change-in-cigarette-other

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.