Psychedelic Experiences Linked to Reduced Cannabis Use and Greater Psychological Flexibility

Cannabis users who had a significant psychedelic experience reported sustained reductions in cannabis use scores, with stronger 'mystical' qualities of the experience predicting greater reductions.

Romeo, B et al.·Journal of psychoactive drugs·2025·Preliminary EvidenceCross-Sectional
RTHC-07518Cross SectionalPreliminary Evidence2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Cross-Sectional
Evidence
Preliminary Evidence
Sample
Not reported

What This Study Found

Among 152 cannabis users who reported a significant past psychedelic experience, average cannabis use disorder scores (CUDIT) decreased significantly after the psychedelic experience. The intensity of mystical qualities during the experience predicted the degree of cannabis reduction. Participants also reported lasting improvements in psychological flexibility following the experience.

Key Numbers

152 cannabis users surveyed. Significant reduction in CUDIT scores post-psychedelic experience. Mystical experience intensity correlated with degree of cannabis reduction (p=.01). Psychological flexibility also improved (p=.04).

How They Did This

Online retrospective survey of 152 cannabis users who reported a significant past psychedelic experience. Compared self-reported cannabis use (CUDIT scores) before and after the psychedelic experience. Assessed mystical experience characteristics and psychological flexibility changes.

Why This Research Matters

Cannabis use disorder has few effective treatments. The finding that naturalistic psychedelic experiences are associated with reduced cannabis use adds to a growing body of research suggesting psychedelic-assisted approaches could address substance use disorders, including cannabis dependence.

The Bigger Picture

Psychedelic-assisted therapy is being actively studied for alcohol and tobacco use disorders, with promising early results. This study extends the potential application to cannabis use disorder, though the naturalistic, retrospective design means much more rigorous research is needed before drawing clinical conclusions.

What This Study Doesn't Tell Us

Retrospective and self-report design, highly susceptible to recall bias. Self-selected sample of people who had 'significant' psychedelic experiences. No control group. No verification of actual substance use changes. Cannot determine whether the psychedelic experience caused the changes or coincided with other life factors.

Questions This Raises

  • ?Would controlled psychedelic-assisted therapy reduce cannabis use in clinical trials?
  • ?What specific mechanisms link mystical experiences to behavior change?
  • ?Could psychedelic experiences worsen cannabis use in some individuals?

Trust & Context

Key Stat:
Mystical experience intensity predicted cannabis use reduction
Evidence Grade:
Preliminary: retrospective self-report survey with no control group and high risk of recall and selection bias.
Study Age:
Published in 2025, based on retrospective reports.
Original Title:
Significant Psychedelic Experiences Evaluated for Mystical Characteristics Associated with Cannabis Use Reduction and Psychological Flexibility Improvement: A Naturalistic Cross-Sectional Retrospective Survey.
Published In:
Journal of psychoactive drugs, 57(4), 374-385 (2025)
Database ID:
RTHC-07518

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study

A snapshot of a population at one point in time.

What do these levels mean? →

Frequently Asked Questions

Can psychedelics help people reduce cannabis use?

This retrospective survey found associations between significant psychedelic experiences and reduced cannabis use scores, with mystical qualities predicting greater reductions. However, the design cannot prove the psychedelic experience caused the change.

What makes a psychedelic experience more likely to reduce substance use?

In this study, stronger 'mystical' characteristics of the psychedelic experience (such as feelings of unity, transcendence, and deep meaning) were associated with greater reductions in cannabis use and improvements in psychological flexibility.

Read More on RethinkTHC

Cite This Study

RTHC-07518·https://rethinkthc.com/research/RTHC-07518

APA

Romeo, B; Kervadec, E; Fauvel, B; Strika-Bruneau, L; Amirouche, A; Verroust, V; Piolino, P; Benyamina, A. (2025). Significant Psychedelic Experiences Evaluated for Mystical Characteristics Associated with Cannabis Use Reduction and Psychological Flexibility Improvement: A Naturalistic Cross-Sectional Retrospective Survey.. Journal of psychoactive drugs, 57(4), 374-385. https://doi.org/10.1080/02791072.2024.2375720

MLA

Romeo, B, et al. "Significant Psychedelic Experiences Evaluated for Mystical Characteristics Associated with Cannabis Use Reduction and Psychological Flexibility Improvement: A Naturalistic Cross-Sectional Retrospective Survey.." Journal of psychoactive drugs, 2025. https://doi.org/10.1080/02791072.2024.2375720

RethinkTHC

RethinkTHC Research Database. "Significant Psychedelic Experiences Evaluated for Mystical C..." RTHC-07518. Retrieved from https://rethinkthc.com/research/romeo-2025-significant-psychedelic-experiences-evaluated

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.