CBD blocked THC-induced nausea in rats through serotonin receptors
CBD prevented THC-induced nausea and stress hormone elevation in rats, with the anti-nausea effect working through 5-HT1A serotonin receptors.
Quick Facts
What This Study Found
CBD (5 mg/kg) blocked the establishment of THC-induced conditioned gaping (a measure of nausea) in rats, and this effect was reversed by a 5-HT1A receptor antagonist (WAY-100635). CBD also reversed the THC-induced increase in corticosterone (stress hormone).
Key Numbers
CBD at 5 mg/kg blocked THC-induced gaping (p=0.007). THC at 10 mg/kg significantly increased corticosterone (p=0.04). CBD reversed the corticosterone elevation.
How They Did This
Animal study using conditioned gaping paradigm in rats to measure nausea. Tested CBD pretreatment against THC-induced nausea and used receptor antagonists to identify the mechanism. Serum corticosterone measured to assess stress response.
Why This Research Matters
Cannabinoid hyperemesis syndrome (CHS) involves intense nausea from high-dose THC use. Understanding how CBD counteracts THC-induced nausea could inform CHS treatment strategies.
The Bigger Picture
This suggests CBD may counteract some of the adverse effects of THC through serotonin pathways, providing a biological rationale for balanced THC:CBD cannabis products.
What This Study Doesn't Tell Us
Animal study using rats, which cannot vomit. Conditioned gaping is a proxy for nausea. Doses and pharmacokinetics may not translate directly to humans.
Questions This Raises
- ?Would CBD help manage cannabinoid hyperemesis syndrome in humans?
- ?What CBD:THC ratios would be needed to prevent nausea in regular users?
Trust & Context
- Key Stat:
- CBD blocked THC-induced nausea via 5-HT1A receptors (p=0.007)
- Evidence Grade:
- Well-controlled animal study with clear mechanism identification, but findings need human validation.
- Study Age:
- Published in 2022.
- Original Title:
- Cannabidiol Interferes with Establishment of Δ9-Tetrahydrocannabinol-Induced Nausea Through a 5-HT1A Mechanism.
- Published In:
- Cannabis and cannabinoid research, 7(1), 58-64 (2022)
- Authors:
- DeVuono, Marieka V(10), La Caprara, Olivia(2), Petrie, Gavin N(6), Limebeer, Cheryl L, Rock, Erin M, Hill, Matthew N, Parker, Linda A
- Database ID:
- RTHC-03804
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What is cannabinoid hyperemesis syndrome?
CHS is a condition characterized by intense nausea and vomiting caused by regular, high-dose THC use. It has been linked to a dysregulated stress response.
How did CBD prevent the nausea?
CBD acted through 5-HT1A serotonin receptors. When researchers blocked those receptors with an antagonist drug, CBD's anti-nausea effect was eliminated.
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Cite This Study
https://rethinkthc.com/research/RTHC-03804APA
DeVuono, Marieka V; La Caprara, Olivia; Petrie, Gavin N; Limebeer, Cheryl L; Rock, Erin M; Hill, Matthew N; Parker, Linda A. (2022). Cannabidiol Interferes with Establishment of Δ9-Tetrahydrocannabinol-Induced Nausea Through a 5-HT1A Mechanism.. Cannabis and cannabinoid research, 7(1), 58-64. https://doi.org/10.1089/can.2020.0083
MLA
DeVuono, Marieka V, et al. "Cannabidiol Interferes with Establishment of Δ9-Tetrahydrocannabinol-Induced Nausea Through a 5-HT1A Mechanism.." Cannabis and cannabinoid research, 2022. https://doi.org/10.1089/can.2020.0083
RethinkTHC
RethinkTHC Research Database. "Cannabidiol Interferes with Establishment of Δ9-Tetrahydroca..." RTHC-03804. Retrieved from https://rethinkthc.com/research/devuono-2022-cannabidiol-interferes-with-establishment
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.