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Study breakdown

What makes cannabis use disorder treatment work: motivation, coping skills, self-efficacy, and therapeutic relationship

Scoping ReviewModerate evidence
The takeaway

A scoping review found successful CUD treatment depends on duration, motivation enhancement, coping skills, self-efficacy, and therapeutic alliance, while sex, ethnicity, age, and comorbidities predict who benefits most.

Addiction therapists, treatment program designers, clinical psychologists.

CUD is now the most common first-time drug treatment reason in the EU

What the researchers found

Specific mediators: treatment duration, motivation to change, coping skills, self-efficacy, multi-component integration. Common mediators: therapeutic alliance, empathy, expectations, cultural adaptation. Moderators: sex, ethnicity, age, comorbid disorders.

Why it matters

CUD is the most common first-time drug treatment reason in the EU. Understanding why some treatments work for some people enables precision-matched care.

The numbers in context

CUD is the most common first-time drug treatment in EU. Mediators: duration, motivation, coping, self-efficacy. Common factors: alliance, empathy, expectations. Moderators: sex, ethnicity, age, comorbidity.

How the study worked

Scoping review of empirically evaluated studies using defined cannabis-related outcome measures, categorizing factors as mediators or moderators.

What this study cannot tell us

Scoping methodology is broader than systematic review. Heterogeneous studies. Mostly Western, high-income country research.

How to read the evidence

Scoping review provides broad overview but lacks systematic rigor and meta-analytic precision.

When this study was published

Published in 2025.

The bigger picture

Identifying what works and for whom in CUD treatment enables a precision medicine approach to addiction care.

Questions still open

  • Can treatment be personalized in real-world settings? Which mediator combinations produce best outcomes?

Common questions

What makes cannabis addiction treatment effective?
Key ingredients include sufficient duration, building motivation, learning coping skills, developing self-efficacy, and a good therapeutic relationship.
Does the same treatment work for everyone?
No. Sex, ethnicity, age, and comorbid conditions all predict who benefits from which treatments.

Read the original research

Predictors of effective therapy among individuals with Cannabis Use Disorder: a review of the literature.

European archives of psychiatry and clinical neuroscience, 275(2), 341-353

Citation

Feingold, Daniel; Tzur Bitan, Dana; Ferri, Marica; Hoch, Eva. (2025). Predictors of effective therapy among individuals with Cannabis Use Disorder: a review of the literature.. European archives of psychiatry and clinical neuroscience, 275(2), 341-353. https://doi.org/10.1007/s00406-024-01781-4

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