Systematic review identified multiple treatments for cannabinoid hyperemesis syndrome
A systematic review of 17 studies found cannabis cessation is the most effective CHS treatment, with hot baths, capsaicin cream, haloperidol, and other medications providing symptom relief.
Quick Facts
What This Study Found
Cannabis cessation is the most successful management for CHS. Other treatments demonstrating symptom relief include hot water hydrotherapy, topical capsaicin cream, haloperidol, droperidol, benzodiazepines, propranolol, and aprepitant.
Key Numbers
225 records retrieved, 17 included. Cannabis use duration of 6 months to 11 years may precipitate CHS. Rome IV criteria require symptoms for at least 6 months. Multiple treatment options identified beyond cessation.
How They Did This
Systematic review searching PubMed, MEDLINE, Cochrane, EMBASE, and Google Scholar for CHS articles from January 2009 to June 2021. Of 225 results, 17 were deemed relevant and reviewed by two independent reviewers.
Why This Research Matters
CHS is increasingly recognized in emergency departments and clinical settings. This review consolidates the evidence on treatment options, giving clinicians a practical reference for managing this condition.
The Bigger Picture
As cannabis use becomes more common, CHS recognition and management become more important. Having a systematic summary of treatment options helps emergency physicians and primary care providers respond effectively.
What This Study Doesn't Tell Us
Only 17 studies met inclusion criteria, indicating limited evidence overall. Most included studies were case reports or small series. No randomized trials comparing treatments were available.
Questions This Raises
- ?Which treatment is most effective for acute CHS episodes in the emergency department?
- ?Can any medication prevent CHS in chronic cannabis users?
- ?Why does hot water hydrotherapy provide relief?
Trust & Context
- Key Stat:
- 6 months to 11 years of cannabis use may precipitate CHS
- Evidence Grade:
- Moderate: systematic review methodology, but limited by small number of included studies and lack of randomized trials.
- Study Age:
- Published in 2022.
- Original Title:
- A Systematic Review on Cannabis Hyperemesis Syndrome and Its Management Options.
- Published In:
- Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 31(1), 29-38 (2022)
- Authors:
- Senderovich, Helen(2), Patel, Preet, Jimenez Lopez, Briam, Waicus, Sarah
- Database ID:
- RTHC-04211
Evidence Hierarchy
Analyzes all available research on a topic using a structured method.
What do these levels mean? →Frequently Asked Questions
What are the Rome IV criteria for CHS?
They require cannabinoid use and persistence of nausea and vomiting symptoms for at least the past 6 months to diagnose CHS.
Why does capsaicin cream work for CHS?
Capsaicin activates TRPV1 receptors, which are part of the same system that cannabinoids interact with. The exact mechanism is not fully understood, but topical capsaicin applied to the abdomen has provided relief in multiple reports.
Is CHS the same as cyclic vomiting syndrome?
They share similar symptoms, but CHS is specifically linked to chronic cannabinoid use and resolves with cessation. Cyclic vomiting syndrome has different underlying causes.
Read More on RethinkTHC
- 420-sober-survival-guide
- CBT-cannabis-recovery
- THC-potency-increase-over-time
- cannabis-harm-reduction-opioids-alcohol-replacement
- cannabis-legalization-effects-health-data
- cannabis-relapse-cycle-pattern
- cannabis-tolerance-break-guide
- cold-turkey-vs-taper-quit-weed
- dating-sober-after-quitting-weed
- exercise-quitting-weed-anxiety-brain
- grieving-quitting-weed-loss
- help-someone-quit-weed
- how-to-cut-back-on-weed-moderation
- how-to-quit-weed
- journaling-weed-withdrawal
- marijuana-anonymous-SMART-recovery-compare
- meditation-mindfulness-weed-withdrawal
- microdosing-cannabis-benefits
- partner-still-smokes-weed
- partner-still-smokes-weed-quitting
- pink-cloud-sobriety-cannabis
- quit-weed-cold-turkey
- quit-weed-or-cut-back-which-is-better
- quit-weed-regret-went-back
- quitting-weed-20s
- quitting-weed-30s
- quitting-weed-after-years
- quitting-weed-during-crisis-divorce-job-loss
- quitting-weed-exercise
- quitting-weed-grief-loss-coping
- quitting-weed-legal-state
- quitting-weed-success-stories
- quitting-weed-triggers-environment
- relapsed-smoking-weed-what-to-do
- relapsed-weed
- safer-cannabis-use-guidelines
- should-i-quit-weed
- sober-music-festival-concert-without-weed
- sober-october-weed
- supplements-weed-withdrawal
- telling-friends-quitting-weed
- tolerance-break-weed
- weed-for-opioid-withdrawal
- weed-relapse-prevention-plan
- weed-relapse-why-it-happens
- weed-ritual-replacement
- weed-ruined-relationships
- weed-social-media-triggers-quit
Cite This Study
https://rethinkthc.com/research/RTHC-04211APA
Senderovich, Helen; Patel, Preet; Jimenez Lopez, Briam; Waicus, Sarah. (2022). A Systematic Review on Cannabis Hyperemesis Syndrome and Its Management Options.. Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 31(1), 29-38. https://doi.org/10.1159/000520417
MLA
Senderovich, Helen, et al. "A Systematic Review on Cannabis Hyperemesis Syndrome and Its Management Options.." Medical principles and practice : international journal of the Kuwait University, 2022. https://doi.org/10.1159/000520417
RethinkTHC
RethinkTHC Research Database. "A Systematic Review on Cannabis Hyperemesis Syndrome and Its..." RTHC-04211. Retrieved from https://rethinkthc.com/research/senderovich-2022-a-systematic-review-on
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.