CHS Audit: Young Males Dominated ER Presentations, with 43% Returning Within the Study Period

A 6-year Melbourne ER audit identified 142 CHS presentations from 67 unique patients, with 43% returning during the study period, most within 3 months, and all reporting daily cannabis use.

Rotella, Joe A et al.·Emergency medicine Australasia : EMA·2022·Moderate EvidenceRetrospective Cohort
RTHC-04182Retrospective CohortModerate Evidence2022RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Retrospective Cohort
Evidence
Moderate Evidence
Sample
N=29

What This Study Found

142 presentations from 67 unique patients. 43% (29 patients) represented during the study period, most within 3 months. Males were overrepresented (68.7%). Median age was 31. All had daily cannabis use. Cyclical nausea/vomiting was the most common feature. Lab findings: elevated white cells with neutrophilia (75.8%), mild low potassium (57.9%), normal lipase, and low CRP.

Key Numbers

142 presentations, 67 unique patients. Re-presentation rate: 43% (29/67). Most re-presented within 3 months. 68.7% male. Median age 31 (IQR 23-35). Neutrophilia: 75.8%. Hypokalaemia: 57.9%. Normal lipase. CRP <50: 98.2%. No ICU admissions. No deaths.

How They Did This

Retrospective chart review of adult CHS presentations at an urban Melbourne ED from January 2015 to January 2021. Examined demographics, cannabis use patterns, clinical features, lab results, imaging, treatment, and outcomes including re-presentation rates.

Why This Research Matters

The high re-presentation rate (43%) highlights CHS as a chronic, recurring condition that significantly burdens emergency departments. The lab profile (normal lipase, low CRP) could help clinicians distinguish CHS from other causes of cyclic vomiting.

The Bigger Picture

This Australian data complements North American CHS studies, showing the condition is a global phenomenon. The detailed lab characterization is particularly useful for developing diagnostic criteria, as CHS remains a diagnosis of exclusion.

What This Study Doesn't Tell Us

Single-center retrospective study in outer Melbourne. CHS diagnosis depended on documentation, which may vary by clinician. Patients who sought care elsewhere would be missed. The study could not assess cannabis cessation rates or long-term outcomes.

Questions This Raises

  • ?Would a CHS-specific discharge protocol reduce the 43% re-presentation rate?
  • ?Could the lab profile (normal lipase, mild CRP, hypokalaemia) be incorporated into formal diagnostic criteria?
  • ?What interventions best support cannabis cessation in CHS patients?

Trust & Context

Key Stat:
43% of CHS patients re-presented to the ER, most within 3 months
Evidence Grade:
Moderate: 6-year audit at a single center with detailed clinical characterization, though limited by retrospective design.
Study Age:
Published in 2022, covering 2015-2021.
Original Title:
Cannabinoid hyperemesis syndrome: A 6-year audit of adult presentations to an urban district hospital.
Published In:
Emergency medicine Australasia : EMA, 34(4), 578-583 (2022)
Database ID:
RTHC-04182

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-ControlFollows or compares groups over time
This study
Cross-Sectional / Observational
Case Report / Animal Study

Looks back at existing records to find patterns.

What do these levels mean? →

Frequently Asked Questions

How often do CHS patients come back to the ER?

In this study, 43% of CHS patients returned during the 6-year period, with most coming back within 3 months. Some patients had multiple return visits, suggesting the condition is highly recurrent without cannabis cessation.

What lab tests help diagnose CHS?

CHS patients typically had elevated white blood cells with neutrophilia (75.8%), mild low potassium (57.9%), normal lipase, and CRP below 50 (98.2%). The normal lipase is particularly useful for ruling out pancreatitis as the cause of vomiting.

Read More on RethinkTHC

Cite This Study

RTHC-04182·https://rethinkthc.com/research/RTHC-04182

APA

Rotella, Joe A; Ferretti, Olivia G; Raisi, Elham; Seet, Hao Rui; Sarkar, Soham. (2022). Cannabinoid hyperemesis syndrome: A 6-year audit of adult presentations to an urban district hospital.. Emergency medicine Australasia : EMA, 34(4), 578-583. https://doi.org/10.1111/1742-6723.13944

MLA

Rotella, Joe A, et al. "Cannabinoid hyperemesis syndrome: A 6-year audit of adult presentations to an urban district hospital.." Emergency medicine Australasia : EMA, 2022. https://doi.org/10.1111/1742-6723.13944

RethinkTHC

RethinkTHC Research Database. "Cannabinoid hyperemesis syndrome: A 6-year audit of adult pr..." RTHC-04182. Retrieved from https://rethinkthc.com/research/rotella-2022-cannabinoid-hyperemesis-syndrome-a

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.