Cannabis Involvement in PTSD Emergency Visits Rose 151% During Canada's Legalization Era

In Ontario, Canada, cannabis co-involvement in PTSD-related emergency department visits increased 151% from 2008 to 2022, outpacing the 58% increase in alcohol co-involvement over the same period.

Perrault-Sequeira, Laurent et al.·The American journal on addictions·2025·Moderate EvidenceRetrospective Cohort
RTHC-07353Retrospective CohortModerate Evidence2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Retrospective Cohort
Evidence
Moderate Evidence
Sample
Not reported

What This Study Found

Among 381,450 PTSD ED visits in Ontario, cannabis co-involvement increased by 151% (from 0.13 to 0.33 per 100,000) between the first and last cannabis policy periods, while alcohol co-involvement increased by 58%. However, the increase was a steady upward trend not clearly tied to specific policy changes, suggesting normalization and increased access rather than legalization itself drove the increase.

Key Numbers

381,450 PTSD ED visits. 4,593 (1.29%) co-involved cannabis. 11,625 (3.05%) co-involved alcohol. Cannabis co-involvement: IRR 2.51 (151% increase, 0.13 to 0.33 per 100,000). Alcohol co-involvement: IRR 1.58 (58% increase). No significant association between specific policy periods and cannabis trend.

How They Did This

Repeated cross-sectional study using Ontario health administrative data identifying all ED visits for PTSD among residents aged 10-105 from 2008-2022 (15.7 million total). Cannabis and alcohol co-diagnoses were tracked across four cannabis policy periods, analyzed using Poisson models.

Why This Research Matters

People with PTSD are at elevated risk for cannabis use disorder. This population-level data shows that as cannabis access expanded, cannabis-related complications in PTSD patients grew substantially faster than alcohol-related complications, highlighting a population that may need targeted intervention.

The Bigger Picture

PTSD and cannabis use have a complicated relationship: some patients report symptom relief, but cannabis use disorder rates are elevated in this population. The steady increase in cannabis-PTSD ED visits regardless of specific policy changes suggests that broader cultural shifts toward cannabis normalization, rather than legislation alone, are driving increased use among this vulnerable population.

What This Study Doesn't Tell Us

Administrative data using ICD codes may undercount both cannabis involvement and PTSD. Cannot determine whether cannabis contributed to the ED visit or was incidentally documented. Cannot assess whether patients were using cannabis therapeutically or recreationally. Ontario-specific findings.

Questions This Raises

  • ?Is the increase in cannabis-PTSD ED visits driven by more cannabis use, more documentation, or both?
  • ?Are PTSD patients who use cannabis having worse outcomes?
  • ?Would improved access to evidence-based PTSD treatment reduce reliance on cannabis self-medication?

Trust & Context

Key Stat:
151% increase in cannabis-involved PTSD ER visits vs 58% for alcohol
Evidence Grade:
Moderate evidence from a large population-based study using health administrative data over 14 years, though limited by the observational design and ICD coding constraints.
Study Age:
2025 study analyzing Ontario health data from 2008-2022 across multiple cannabis policy periods.
Original Title:
Cannabis involvement in posttraumatic stress disorder emergency department visits after cannabis legalization.
Published In:
The American journal on addictions, 34(4), 404-414 (2025)
Database ID:
RTHC-07353

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-ControlFollows or compares groups over time
This study
Cross-Sectional / Observational
Case Report / Animal Study

Looks back at existing records to find patterns.

What do these levels mean? →

Frequently Asked Questions

Did cannabis legalization increase PTSD-related ER visits?

Cannabis co-involvement in PTSD ED visits increased 151% from 2008 to 2022, but the increase was a steady trend not clearly tied to specific legalization dates. This suggests normalization and increased access, rather than legalization per se, drove the increase.

Should people with PTSD be concerned about cannabis use?

This study adds to evidence that PTSD and cannabis use disorder frequently co-occur. While some PTSD patients report symptom relief from cannabis, the 151% increase in cannabis-involved PTSD ER visits suggests that population-level cannabis expansion is leading to more acute presentations in this vulnerable group.

Read More on RethinkTHC

Cite This Study

RTHC-07353·https://rethinkthc.com/research/RTHC-07353

APA

Perrault-Sequeira, Laurent; Pugliese, Michael; MacDonald-Spracklin, Rachael; Xiao, Jennifer; McCarthy, Stephen; Myran, Daniel T. (2025). Cannabis involvement in posttraumatic stress disorder emergency department visits after cannabis legalization.. The American journal on addictions, 34(4), 404-414. https://doi.org/10.1111/ajad.70014

MLA

Perrault-Sequeira, Laurent, et al. "Cannabis involvement in posttraumatic stress disorder emergency department visits after cannabis legalization.." The American journal on addictions, 2025. https://doi.org/10.1111/ajad.70014

RethinkTHC

RethinkTHC Research Database. "Cannabis involvement in posttraumatic stress disorder emerge..." RTHC-07353. Retrieved from https://rethinkthc.com/research/perrault-sequeira-2025-cannabis-involvement-in-posttraumatic

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.