In a 15-year study of 455 CVS adults, only 19% fully recovered, and cannabis use was among the strongest negative predictors (OR 0.36).
CVS patients, gastroenterologists, cannabis users with recurrent vomiting.
Cannabis use: 64% lower odds of complete CVS resolution
What the researchers found
Episodes dropped from 18 to 6.8/year, ER visits from 6.1 to 2, hospitalizations from 2.3 to 0.7. Only 19% had complete resolution. Cannabis use OR 0.36 (p = 0.0007) for resolution. 19 patients (4%) died.
Why it matters
Largest long-term adult CVS follow-up. Cannabis was one of the strongest negative predictors, raising questions about CHS overlap.
The numbers in context
455 patients. Episodes: 18 to 6.8/year. Resolution: 19%. Cannabis OR: 0.36. 4% mortality.
How the study worked
Retrospective analysis of 455 CVS patients at a tertiary center, mean 47.4 months follow-up.
What this study cannot tell us
Retrospective. Single center. Referral bias. Cannot distinguish CVS from CHS in all cases.
How to read the evidence
Large retrospective cohort with multivariable analysis, subject to referral bias.
When this study was published
Published 2023.
The bigger picture
The 4% mortality underscores CVS severity. Some patients labeled CVS may actually have CHS.
Questions still open
- How many CVS patients actually have CHS?
- Would cannabis cessation improve CVS outcomes?
Common questions
Does cannabis affect CVS outcomes?
Can adults recover from CVS?
Read the original research
Clinical characteristics and long-term outcomes in patients with cyclic vomiting syndrome: A 15-year experience at a tertiary referral center.
Neurogastroenterology and motility, 35(7), e14571
Citation
Partovi, Omeed; Patel, Milan; Kovacic, Katja; Petrova, Ana; Garacchi, Zhuping; Venkatesan, Thangam. (2023). Clinical characteristics and long-term outcomes in patients with cyclic vomiting syndrome: A 15-year experience at a tertiary referral center.. Neurogastroenterology and motility, 35(7), e14571. https://doi.org/10.1111/nmo.14571
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