Endocannabinoid Levels Track with Pancreatitis Stage and Pain ↗
Case-control study of 231 people found anandamide levels rose with pancreatitis severity while 2-AG dropped with pain intensity.
Research library — page 102
Browse more cannabis research, findings, methods, and limitations.
Even Low-Dose CBD Increased Blood Levels of the Antidepressant Amitriptyline ↗
A single 30 mg CBD dose increased amitriptyline blood levels by 13% in healthy volunteers, demonstrating drug interaction potential even at low doses.
Blocking Cannabinoid Receptors in Newborn Mice Produced ADHD and Tourette-Like Behaviors ↗
Disrupting cannabinoid receptors in newborn mice produced a combined ADHD/Tourette-like phenotype with vocal tics, hyperactivity, and learning deficits, especially in males.
Cannabis Use Disorder Linked to More Complications After Wrist Fracture Surgery ↗
Among 13,405 wrist fracture surgery patients, those with cannabis use disorder had double the ER visit rate and higher readmission rates within 90 days.
Cannabis Users May Need More Sedation for GI Procedures ↗
Review found cannabis users often need higher sedation doses for endoscopy, with inhalation users facing extra airway risks like bronchospasm.
Pregnant People Avoid Telling Providers About Cannabis Use Due to Fear of Judgment and Reporting ↗
Interviews with 34 pregnant cannabis users revealed most providers never asked about use, and patients feared judgment and child welfare reporting if they disclosed.
CBD Reduced Seizures in Most Children with Drug-Resistant Epilepsy ↗
Among 50 children with drug-resistant epilepsy treated with CBD for at least six months, 56% had meaningful seizure reduction and 16% became seizure-free.
Bias-Based Bullying Linked to Much Higher Cannabis Use Among Minority Youth ↗
Survey of 82,933 Minnesota students found bias-based bullying was associated with 50-68% higher regular cannabis use among youth with minoritized identities.
What Happens to Your Memory When You Mix Weed and Alcohol? ↗
Mixing legal-market cannabis with alcohol reduced word recall by about one word per trial—but only for men, not women.
Heavy Lifetime Cannabis Use Linked to Lower Brain Activity During Memory Tasks ↗
Brain imaging of 1,003 young adults found heavy lifetime cannabis users had significantly lower brain activation during working memory tasks.
Only One-Third of Postpartum Mothers Received Any Provider Counseling About Marijuana ↗
Survey of 484 postpartum mothers found only one-third received provider counseling about marijuana, despite 60% having ever used it.
Can Young People Quit Vaping and Cannabis at the Same Time? ↗
About a third of teen dual users quit both vaping and cannabis at 7 months—and quitting vaping appeared to help with quitting cannabis too.
Health Professionals Became the Top Cannabis Information Source as Traditional Media Declined ↗
Longitudinal study of 5,053 US adults found health professionals became the top source for cannabis information while traditional media declined sharply.
16-Year Trends Show Fewer People with Cannabis Use Disorder Are Getting Treatment ↗
Analysis of 16 years of national data found CUD treatment rates declined while barriers like cost, awareness, and stigma grew.
N-Acetylcysteine Did Not Help Youth Quit Cannabis Without Contingency Management ↗
Rigorous trial of 192 youth found N-acetylcysteine was no better than placebo for cannabis use disorder when not paired with contingency management.
Hemp Cigarettes Contain Similar Metal Levels as Tobacco, with Lower Cadmium but Higher Chromium in Some Brands ↗
Lab analysis of 14 hemp cigarette brands found metal levels similar to tobacco, with lower cadmium but several brands exceeding state limits for other metals.
Nearly 7% of Pregnant Women Used Cannabis, with Highest Rates in the First Trimester ↗
National survey of 94,225 women found 6.8% of pregnant women used cannabis, with first-trimester rates reaching 10-14%, mostly by smoking.
Bisexual Adolescents Had Nearly Double the Odds of Marijuana Use Compared to Heterosexual Peers ↗
National survey of 10,361 adolescents found bisexual youth had 85% higher odds of marijuana use than heterosexual peers, with disparities varying by age and sex.
Cannabis Alone Did Not Raise Suicide Risk in Veterans, but Combined with Heavy Drinking It Did ↗
Study of 1,098 veterans found cannabis use alone was not linked to suicide risk, but combining it with hazardous drinking produced the highest risk for suicidal behavior.
The Endocannabinoid System Drives Immune Cell Infiltration in Eosinophilic Esophagitis ↗
Study found the endocannabinoid system drives eosinophil infiltration in eosinophilic esophagitis, with CB2 receptor blocking reducing inflammation in mice.
Pediatric Patients with Cannabis Use Disorder Had Higher Rates of Urinary Symptoms ↗
Large database study of ~9 million pediatric patients found cannabis use disorder linked to significantly higher rates of pelvic pain, bladder symptoms, and UTIs.
COVID-19 Worsened Substance Use Disparities Among Victimized Adolescents ↗
Analysis of 52,679 US adolescents found COVID-19 widened substance use disparities, with multiply-victimized youth reaching 3.5x higher marijuana use odds during the pandemic.
Lifetime Cannabis Use Linked to Larger Brain Volumes and Better Cognition in Middle-Aged and Older Adults ↗
UK Biobank data from adults aged 40-70 found lifetime cannabis use associated with larger brain volumes in key regions and better cognitive performance.
CBD-Rich Cannabis Extract Reduced Behavioral Problems in Children with Severe Autism ↗
Prospective study of 16 children with severe autism found CBD-rich extract reduced internalizing behaviors after three months, with caregivers also reporting improved mental health.
Genetic Analysis Suggests Cannabis Use May Increase Risk of Parkinson's Disease and ADHD in Women ↗
Mendelian randomization study using genetic data found potential causal links between cannabis use and increased risk of Parkinson's disease and ADHD in women.
Mindfulness-Based Therapy Reduced Cannabis and Cocaine Cravings in People with Alcohol Problems ↗
Pilot trial of 50 adults found mindfulness-based therapy (MORE) significantly reduced cannabis and cocaine cravings in people being treated for alcohol problems.
Marijuana Users Had Higher Hip Dislocation Rates After Hip Replacement Surgery ↗
Among 3,308 matched hip replacement patients, marijuana users had higher dislocation rates but no difference in opioid use after surgery.
Cannabis Use Lowered a Key Endocannabinoid in People with Schizophrenia ↗
Study of 93 people found lifetime cannabis use lowered the endocannabinoid 2-AG in schizophrenia patients, while non-clozapine antipsychotics altered CB2 receptors.
Treating PTSD and Cannabis Dependence Together After Sexual Assault ↗
A new brief therapy combining trauma writing with cannabis coping skills showed early promise in three young women after sexual assault—but needs rigorous testing.
27% of Women with HIV Used Cannabis, with Half Varying Their Use Frequency Over Time ↗
Study of 1,246 women with HIV found 27% used cannabis (twice the national average), with half changing their use frequency over 18 months.
CBT with Motivational Enhancement Is the Best-Supported Psychotherapy for Cannabis Use Disorder ↗
Meta-analysis of 22 trials (3,304 people) found MET-CBT significantly increased cannabis abstinence but also had higher dropout rates.
Cannabis Consequences Predicted Later Depression More Than Depression Predicted Cannabis Use ↗
Two-year study of 961 emerging adults found negative cannabis consequences predicted later depression more than depression predicted cannabis use, especially in women.
Starting Cannabis Earlier Specifically Increases Risk for Cannabis Use Disorder, Not Other Drug Problems ↗
Systematic review of 16 prospective studies found early cannabis use onset specifically predicted cannabis use disorder, not other substance problems.
Combining THC and Opioids Did Not Improve Pain Relief for Knee Osteoarthritis ↗
Controlled trial of 21 knee OA patients found no pain benefit from combining synthetic THC with an opioid, and the combination caused more side effects.
One in Five Cannabis-Related ER Visits Among Young People Involved Fainting ↗
Analysis of nearly 25,000 cannabis-related ER visits found 21.7% involved syncope (fainting), with an 8.6-fold higher prevalence compared to non-users.
Most Youth with Mood Disorders Believe Cannabis and CBD Treat Mental Health, Despite Lack of Evidence ↗
Survey of 84 youth in mood disorder treatment and 66 parents found most believe cannabis and CBD effectively treat mental health conditions.
Most Cannabis Edibles Contain 100+ mg THC and Use Child-Appealing Marketing ↗
Analysis of 2,282 cannabis edibles found most contained 100+ mg THC, with widespread use of child-appealing characters, colors, and flavors.
Oral Cannabis Did Not Help Chemotherapy-Induced Nerve Pain in a Small Pilot Trial ↗
Pilot trial of 12 women found oral cannabis capsules (100 mg CBD/5 mg THC TID) did not outperform placebo for chemotherapy-induced nerve pain.
Cannabinoid Hyperemesis Syndrome Caused Severe Vomiting Mistaken for Morning Sickness ↗
Two pregnant women with severe cyclic vomiting were diagnosed with cannabinoid hyperemesis syndrome after the hot bathing relief pattern was identified; symptoms resolved with cannabis cessation.
Cannabis Use Triggered Life-Threatening Heart Condition Requiring Intensive Cardiac Support ↗
A 63-year-old woman developed Takotsubo cardiomyopathy with an ejection fraction of 15-20% after cannabis use, requiring 4 weeks of intensive cardiac support to recover.
23% of Cannabis Users Drove Within Two Hours of Use ↗
Survey of 979 cannabis users found 23% drove within 2 hours of use, with males, frequent users, and medical cannabis patients at higher risk.
Does Medical Cannabis Help With Cancer Symptoms? A Rigorous Trial Says Mostly No ↗
A double-blind trial of 144 cancer patients found THC:CBD oil didn't improve overall symptoms vs. placebo—but pain scores did improve specifically.
Cannabis Use During Pregnancy Disrupted Blood Vessel Function in the Placenta ↗
Placental tissue study found cannabis use completely eliminated endocannabinoid-mediated blood vessel relaxation and greatly reduced nitric oxide signaling.
Warning Labels on Delta-8 THC Products Increased Youth Awareness of Intoxication and Harm ↗
Experiment with 3,647 adolescents found warning labels on delta-8 THC products increased perceived risk and intoxication but did not reduce use susceptibility.
Potent Synthetic Cannabinoid 5F-AKB48 Emerged as an Adolescent Drug in France ↗
French poison centers recorded 304 cases of synthetic cannabinoid 5F-AKB48, mostly in teenage males vaping the drug, with 4% experiencing seizures or coma.
Cannabis Legalization Drove Greater CUD Increases Among Veterans with Psychiatric Disorders ↗
Analysis of 4+ million VHA patients over 18 years found cannabis legalization drove greater CUD increases among veterans with psychiatric disorders than those without.
Cannabis Use Disorder Rose More Sharply Among US Adults with Psychiatric Conditions ↗
National surveys found cannabis use disorder increased 1.4 points more among adults with psychiatric disorders between 2001 and 2013, confirming VA findings.
Cannabis Hyperemesis Syndrome: A Growing Problem with Rising Cannabis Potency ↗
Comprehensive review found CHS is increasingly common with rising cannabis potency, characterized by daily use for 2+ years, and challenging to treat due to patient skepticism.
About 1 in 10 Chronic Opioid Patients Tested Positive for THC ↗
Review of 244 urine screens from chronic opioid patients found 9.8% tested positive for THC, with inconsistent provider responses to positive results.
Chronic Cannabis Users Had Shorter Telomeres, Suggesting Accelerated Biological Aging ↗
Case-control study of 60 people found chronic cannabis users had significantly shorter telomeres than age-matched controls, suggesting accelerated biological aging.