Bisexual Adolescents Had Nearly Double the Odds of Marijuana Use Compared to Heterosexual Peers

In a national survey of over 10,000 adolescents, bisexual youth had 85% higher odds of past-year marijuana use compared to heterosexual peers, with notable differences by sex and age.

Grigsby, Timothy J et al.·The American journal on addictions·2025·Strong EvidenceCross-Sectional
RTHC-06591Cross SectionalStrong Evidence2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Cross-Sectional
Evidence
Strong Evidence
Sample
N=10,361

What This Study Found

Among 10,361 adolescents aged 12-17, 11.2% reported past-year marijuana use. Bisexual youth had significantly higher odds of marijuana use (OR=1.85) compared to heterosexual youth. Gay/lesbian youth did not have significantly higher marijuana use odds. The disparities varied by sex and age group, with the substance use gap between bisexual and heterosexual youth being particularly pronounced.

Key Numbers

10,361 adolescents; 11.2% past-year marijuana use; bisexual youth marijuana OR=1.85 (95% CI: 1.43-2.40); bisexual tobacco OR=2.00; bisexual alcohol OR=1.32; gay/lesbian tobacco OR=0.47 (lower odds)

How They Did This

Secondary analysis of the 2023 National Survey on Drug Use and Health (N=10,361 youth aged 12-17). Weighted logistic regression examined relationships between sexual orientation and past-year substance use (tobacco, marijuana, alcohol), stratified by age and sex assigned at birth.

Why This Research Matters

Bisexual adolescents face distinct stressors from both heterosexual and gay/lesbian peers, including identity invalidation and dual discrimination. Understanding that these stressors correlate with significantly higher marijuana use can guide targeted prevention that addresses root causes rather than just substance use.

The Bigger Picture

Prevention programs typically treat LGBTQ+ youth as a single group, but this data shows bisexual youth have distinctly different risk profiles from gay/lesbian youth for substance use, requiring tailored approaches.

What This Study Doesn't Tell Us

Cross-sectional design cannot establish causation. Self-reported sexual orientation among 12-17 year olds may be unstable or underreported. Single-year survey data. Cannot assess frequency or quantity of use beyond past-year prevalence.

Questions This Raises

  • ?What specific stressors drive the elevated substance use rates among bisexual versus gay/lesbian adolescents?
  • ?Would identity-affirming interventions reduce substance use disparities for bisexual youth?

Trust & Context

Key Stat:
Evidence Grade:
Strong: nationally representative sample, 2023 data, appropriate statistical methods with stratified analyses.
Study Age:
2025 publication using 2023 NSDUH data
Original Title:
Substance use and sexual orientation among adolescents: Differences by age group and sex in the 2023 National Survey of Drug Use and Health.
Published In:
The American journal on addictions (2025)
Database ID:
RTHC-06591

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study

A snapshot of a population at one point in time.

What do these levels mean? →

Read More on RethinkTHC

Cite This Study

RTHC-06591·https://rethinkthc.com/research/RTHC-06591

APA

Grigsby, Timothy J; Hoopsick, Rachel; Barker, Dylan; Devier, Elise; Amis, Amber; Yockey, R Andrew. (2025). Substance use and sexual orientation among adolescents: Differences by age group and sex in the 2023 National Survey of Drug Use and Health.. The American journal on addictions. https://doi.org/10.1111/ajad.70087

MLA

Grigsby, Timothy J, et al. "Substance use and sexual orientation among adolescents: Differences by age group and sex in the 2023 National Survey of Drug Use and Health.." The American journal on addictions, 2025. https://doi.org/10.1111/ajad.70087

RethinkTHC

RethinkTHC Research Database. "Substance use and sexual orientation among adolescents: Diff..." RTHC-06591. Retrieved from https://rethinkthc.com/research/grigsby-2025-substance-use-and-sexual

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.