Browse more cannabis research, findings, methods, and limitations.
Analysis of 232 pediatric delta-8 THC ingestions found a dose of 1.7 mg/kg identified 98% of cases progressing to severe toxicity, establishing the first clinical reference threshold.
Two independent samples confirm cannabis use disorder exists on a continuum of severity rather than as a binary condition, supporting the DSM-5 dimensional model.
Emerging evidence suggests endocannabinoid system dysregulation may underlie fibromyalgia symptoms, potentially opening the door to targeted cannabinoid-based treatments.
Postmortem brain analysis found CB1 receptor gene expression elevated up to 125% and CB2 expression halved in people with long-term alcohol use disorder.
CBD treatment preserved heart function in mice with heart failure by maintaining mitochondrial function and calcium handling through PPARgamma receptors.
CBDA was the most effective of five cannabinoids tested in ALS mice, outperforming standard medication riluzole in preserving motor neurons and shifting brain immune cells toward an anti-inflammatory state.
Culturally tailored mobile app for Black adults with cannabis use disorder showed strong feasibility and acceptability plus preliminary efficacy signals in a 50-person proof-of-concept RCT.
Six cannabis user profiles were identified in Washington State, with polymodal users (multiple product types) reporting more adverse events than even the most frequent single-product users.
In nearly 3,000 trauma survivors, household income modified the relationship between PTSD symptoms and substance use, influencing whether people turned to tobacco, alcohol, or cannabis.
CBD inhibited EGFR signaling in triple-negative breast cancer cells and doubled their susceptibility to natural killer cell attack by upregulating the FAS death receptor.
Stress increased cocaine use equally in male and female rats, but cannabinoid CB1 receptor blockade reduced intake through different patterns in each sex.
Stress eliminated a form of synaptic plasticity in the brain's insular-to-reward pathway in male rats only, dependent on the endocannabinoid system.
In 1,600 dental patients, marijuana use was the single strongest predictor of dry mouth across all age groups, with 3.1 times higher risk.
A CBD:CBDV combination reduced colitis in mice by suppressing immune cell trafficking through CB2 receptors, providing mechanistic evidence for the entourage effect.
Rasch psychometric analysis of DSM-5 cannabis use disorder in 249 inpatients supports the diagnosis as coherent, though the hazardous use criterion does not fit well.
Nearly 70% of CBD users in an ED survey were taking prescription medications with known drug interaction potential, primarily antidepressants and blood pressure medications.
CBD reshaped gut bacteria in arthritic rats, boosting butyric acid and L-carnitine levels that reduced inflammation in immune cells and joint tissue.
Cannabis smoking clearly causes bronchitis symptoms and impairs lung immune function, but decades of research have failed to establish a consistent link to lung cancer despite the presence of known carcinogens in the smoke.
Meta-analysis of 238 studies found 22% of men who have sex with men engage in chemsex, with cannabis (18%) being the second most commonly used substance in sexual contexts.
Parents of youth who used cannabis described it triggering or worsening severe mental health crises, while frequently encountering healthcare providers who minimized cannabis-related risks.
A teen's nausea and vomiting were blamed on cannabis use and eating disorder — but her seizures the next day revealed acute intermittent porphyria, a rare treatable condition nearly missed due to diagnostic anchoring.
Australian patients seeking medicinal cannabis face practitioner reluctance, high costs, and supply shortages, driving many to unregulated illicit sources despite legalization.
Childhood adversity increased cannabis use disorder risk across all racial groups, but the effect was strongest among Asian/Pacific Islander respondents and interacted with age of onset in race-specific ways.
In 751 cancer patients with chemotherapy-induced neuropathy, THC-dominant cannabis products produced significantly better symptom relief, daily functioning, and quality of life than CBD-dominant products.
Women with fibromyalgia had elevated plasma anandamide that correlated with higher pain and lower fitness, while PAG-thalamus brain connectivity was linked to physical activity.
Youth in early psychosis programs described cannabis as creating family tension around psychosis risk while some family members' own use created contradictory messages and even bonding opportunities.
Oral CBD delayed disease progression (by weight) and improved specific cognitive and social deficits in ALS mice in a sex-dependent manner, but did not rescue motor function.
Cannabis dependence on top of opioid dependence worsened executive function and working memory deficits, though cannabis use without dependence did not add to cognitive impairment.
In 34 UK patients with substance use disorder, medical cannabis improved anxiety, sleep, and quality of life while reducing prescribed opioid doses over six months, with good tolerability.
Anorexia nervosa involves coordinated epigenetic suppression of the endocannabinoid system: reduced cannabinoid receptors and increased endocannabinoid degradation simultaneously impair appetite signaling.
In a clinical trial of 192 young people, cannabis use didn't predict whether they successfully quit nicotine vaping—though co-use days showed higher vaping.
Independent testing of 277 Colorado cannabis products found flower THC labels are frequently inflated (only 57% accurate), while concentrate labels are much more reliable (96% accurate).
Cannabis involvement among mass shooters doubled after medical legalization began in 1996, while remaining stable among non-firearm mass murderers, though causation cannot be established.
Cannabis and tobacco use at any frequency signaled elevated social hardship in 77,000 healthcare users, while binge drinking showed this pattern only at daily frequency.
Cannabis use among young adults increased more in states with adult-use legalization than medical-only states, with retail outlet opening appearing to be the key inflection point.
Cannabis use among New Jersey young adults increased 42% within three months of adult-use retail sales, driven by increases in edibles and dried herb rather than concentrates or vapes.
Israeli patients using medical cannabis for pain or PTSD described elaborate coping strategies for adverse effects and social stigma, including concealment, identity management, and building patient communities.
Oral hemp extract high in CBG and CBD reduced colonic damage and pain in a mouse ulcerative colitis model, supporting further investigation of cannabinoid combinations for IBD.
Literature review finds CBD showed anti-inflammatory and anti-angiogenic effects in experimental endometriosis models, but human clinical evidence for cannabinoid treatment of endometriosis is essentially absent.
Five cannabinoids (THC, CBD, THCV, CBC, CBG) protected insulin-producing cells from metabolic stress-induced death, with most also preserving cell function, suggesting potential relevance for type 2 diabetes.
In college students with elevated worry, fear of anxiety symptoms (anxiety sensitivity) predicted cannabis use and coping motives, while intolerance of uncertainty did not.
A 1:5 CBG:Phytol combination reduced bile acid-induced DNA damage and mutagenicity in esophageal cells, while CB1 receptor expression correlated with esophageal cancer progression in patient tissue.
Psychedelic experiences produced both more positive and more negative effects than cannabis in demographically representative samples, revealing a wider risk-benefit spectrum rather than simply higher risk.
Review maps bidirectional interactions between endocannabinoids and nine neuropeptide systems in the brain, revealing complex regulatory networks relevant to depression and anxiety treatment.
THC was found in 64% of positive newborn drug screens at an Arkansas hospital, with use increasing after state legalization. Exposed infants had lower birth metrics and longer hospital stays.
Mice given THC during adolescence showed lasting social deficits, sensorimotor gating problems, and disrupted cortico-striatal brain connectivity with altered dopamine receptor balance persisting into adulthood.
Cannabis-related ED visits during pregnancy increased 10% during COVID-19, with Medicaid-insured patients showing consistently elevated substance use and racial disparities in cannabis use narrowing.
Tracked 2,762 college students over a year and found anxiety predicted later hazardous cannabis use, with impulsivity traits amplifying the connection.
Survey of 261 women found widespread uncertainty about cannabis and CBD risks during pregnancy, with no difference between pregnant and non-pregnant respondents.
Alzheimer's model mice given daily CBD for two months showed improved memory, less anxiety, and reduced brain oxidative stress.