Oral CBD/CBG hemp extract reduced ulcerative colitis severity and pain in mice | Research

The takeaway

A commercial hemp extract high in CBG and CBD reduced colonic tissue damage and pain responses in a mouse model of ulcerative colitis when administered orally.

IBD researchers, gastroenterologists, and patients interested in cannabinoid-based approaches to inflammatory bowel disease.

What the researchers found

Cannabinoid treatment reduced damage to the colonic epithelium and decreased pain-related responses in DSS-induced colitis mice. Oral administration was effective, suggesting potential for a practical delivery route.

Why it matters

Most cannabinoid-colitis research uses purified compounds or intraperitoneal injection. This study tested a practical oral hemp extract, making findings more relevant to real-world supplementation, though animal-to-human translation remains uncertain.

The numbers in context

Hemp extract high in CBG and CBD. Two administration routes tested (i.p. and oral). Both routes showed efficacy for colonic protection and pain reduction.

How the study worked

DSS-induced ulcerative colitis mouse model treated with a commercial hemp extract high in CBG and CBD via two routes: intraperitoneal and oral. Colonic tissue damage and pain behaviors were assessed.

What this study cannot tell us

Animal model using chemical (DSS) induction, not spontaneous colitis. Commercial extract means exact composition may vary between batches. Limited detail on dosing and outcome quantification in the abstract.

How to read the evidence

Preliminary animal study with practical oral delivery route, but limited outcome detail and chemical colitis model reduce strength.

When this study was published

2025 publication.

The bigger picture

CBG is increasingly recognized as a potentially important cannabinoid for gastrointestinal conditions. Combined with the CBD/CBDV colitis study (RTHC-06519), evidence is building that cannabinoid combinations may be more effective than single compounds for inflammatory bowel conditions.

Questions still open

How does the CBG/CBD combination compare to CBD alone for colitis?
Would this hemp extract show similar benefits in a chronic colitis model?

Common questions

What is CBG?

Cannabigerol (CBG) is a non-psychoactive cannabinoid found in cannabis, sometimes called the "mother cannabinoid" because other cannabinoids are synthesized from its acidic form. It has shown anti-inflammatory properties in preliminary research.

Why test a commercial extract instead of pure compounds?

Commercial extracts are what consumers actually use. Testing them directly is more relevant to real-world applications than purified compounds, though it makes it harder to identify which specific components are responsible for effects.

Read the original research

Orally Administered CBD/CBG Hemp Extract Reduces Severity of Ulcerative Colitis and Pain in a Murine Model.

Journal of clinical medicine, 14(17)

View on PubMed ↗Publisher’s paper ↗

Citation

Godbole, Shivani S; Sun, Dongxiao; Coates, Matthew D; Himmelberger, Victoria J; Roopchand, Diana E; Raup-Konsavage, Wesley M. (2025). Orally Administered CBD/CBG Hemp Extract Reduces Severity of Ulcerative Colitis and Pain in a Murine Model.. Journal of clinical medicine, 14(17). https://doi.org/10.3390/jcm14176095