Low-Dose Cannabinoid Supplement Improved Sleep Quality in a Small Crossover Trial ↗
Small crossover trial found a low-dose cannabinoid supplement (3 mg THC, 6 mg CBN, 10 mg CBD) improved sleep quality and insomnia symptoms vs placebo over 10 days.
Research library — page 103
Browse more cannabis research, findings, methods, and limitations.
ER Patients with Cannabinoid Hyperemesis Had High Pain, Anxiety, and Repeat Visit Rates ↗
Pilot study of 18 CHS patients found high pain severity, elevated anxiety, extensive prior imaging workups, and a 17% 30-day ER return rate.
What Workplace Drug Tests Reveal About Cannabis and Other Substance Use ↗
Among 23,900 Swedish workplace drug tests, 4.6% were positive—with cannabis the most common substance at over 40% of positive results.
Using Cannabis and Alcohol Together Was Linked to Depression in Both Male and Female College Students ↗
Survey of 367 college students found monthly simultaneous cannabis and alcohol use predicted depression in both sexes, with possible male-specific links to anxiety and stress.
37% of California Adults Used Cannabis After Legalization, with 38% of Users Consuming Multiple Times Daily ↗
Survey of 15,208 California adults found 37% used cannabis, with 38% of users consuming multiple times daily, primarily from licensed dispensaries.
Depression and Cannabis Use May Share Brain Reward Processing Deficits, But Evidence Is Inconsistent ↗
Systematic review found depression and cannabis use share brain reward processing regions but no consistent biomarkers, with cannabis amotivation vastly understudied (only 2 studies).
Scientists Built a Better CBD for Epilepsy—From Spearmint, Not Cannabis ↗
Researchers created CBD-like molecules from spearmint compounds that showed stronger anti-seizure effects than natural CBD in mouse models of epilepsy.
Dispensary Staff Recommended Topicals for Pain and Edibles for Sleep, Often Based on Personal Experience ↗
Secret shopper study of 35 Bay Area dispensaries found budtenders consistently recommended topicals for pain and edibles for sleep, based on personal experience.
Cannabis Use in Germany Before and After Partial Legalization ↗
German survey data across five waves (2012-2024) shows cannabis use rose steadily from 4.6% to 9.8%, with the post-legalization increase small and not statistically significant.
What German Family Doctors Think About Cannabis Legalization ↗
Survey of 239 German physicians found most expected more cannabis use after legalization, but few screened patients for it or wanted training.
How Cannabis Use May Generalize Stress Responses Through Brain Changes in Rats ↗
Rat study found THC+CBD use caused stress responses to generalize to neutral stimuli via astrocyte changes in the nucleus accumbens, but only in males.
How Cannabis Poisoning Differs Between Children and Adults ↗
Five-year study of 106 cannabis poisoning cases found children more often had impaired consciousness, while adults had faster heart rates and lower oxygen. Delayed treatment worsened outcomes in children.
CBD for Epilepsy Types Beyond Its Approved Indications ↗
Off-label CBD treatment across 108 patients with various refractory epilepsies achieved 38.9% responder rate at three months, with tolerability similar to approved indications.
Drug-Impaired Driving Patterns in Munich During the COVID-19 Pandemic ↗
Analysis of 6,210 traffic-stop blood samples in Munich found cannabis was the top substance detected (66-67%) throughout the pandemic, with THC metabolite levels rising during lockdowns.
Simultaneous Alcohol and Cannabis Use Linked to More Alcohol Problems Than Using Them Separately ↗
Daily diary study of 116 young adults found simultaneous alcohol and cannabis use (overlapping effects) was linked to roughly double the alcohol-related consequences compared to same-day use without overlap.
Best Treatments for Cannabinoid Hyperemesis Syndrome ↗
Systematic review of 63 CHS cases found capsaicin cream, antipsychotics, and benzodiazepines more effective than standard anti-nausea medications, leading to a proposed treatment algorithm.
Do Medical Marijuana Laws Reduce Opioid Use After Cancer Surgery? ↗
After medical marijuana dispensaries opened, cancer surgery patients were less likely to receive strong opioid prescriptions—but just passing the law wasn't enough.
CBD Isolate Survey: What Chronic Pain Users Report ↗
Anonymous survey found chronic pain sufferers using CBD isolate reported decreased pain at low doses with minimal side effects, though the design limits conclusions.
CBD Protected Against Stress-Induced Liver Damage in Mice ↗
Mouse study found CBD reduced stress-induced liver damage by activating CB2 receptors and protective antioxidant pathways, improving inflammation, fibrosis, and mitochondrial health.
Capsaicin Cream Helped Treat Cannabinoid Hyperemesis Syndrome During Pregnancy ↗
Case report of a pregnant woman with CHS unresponsive to standard anti-emetics who improved significantly with topical capsaicin cream.
How Racial Trauma Affects Substance Use Differently in Multi-Ethnic vs. Mono-Ethnic Young Adults ↗
Large study of 59,529 minority young adults found racial trauma undermined the mental health benefits of psychological well-being, with distinct patterns for multi-ethnic versus mono-ethnic individuals.
Black Parents Describe Racism in Newborn Drug Testing Practices ↗
Interviews with 15 birthing parents found racial bias in newborn drug testing practices, poor communication about cannabis risks in pregnancy, and calls for non-punitive approaches.
Cannabis Use Disorder Linked to More Opioid Prescriptions After Carpal Tunnel Surgery ↗
Matched cohort study found patients with cannabis-related disorders received more opioid prescriptions and had more ER visits after carpal tunnel surgery, with lower outpatient follow-up rates.
How Cannabis Causes "the Munchies": It Boosts Motivation to Eat, Not Just Appetite ↗
PNAS study found cannabis vapor increased food intake in humans and rats by boosting eating motivation and overriding food reward signals, without altering hunger hormones.
Louisiana Medical Marijuana Patients Report Less Pain and Fewer Prescription Painkillers ↗
Survey of 2,000+ Louisiana medical marijuana patients found average pain reduction of 3.4 points and evidence that MM substitutes for prescription painkillers.
German Cannabis Patients Use Much Higher THC Doses Than Expected ↗
Survey of 1,030 German cannabis patients found flower users consumed an average of 336 mg THC daily, nearly 20x more than those using other preparations, with implications for driving safety.
CBD May Normalize Brain Chemistry After Drinking in People with Alcohol Use Disorder ↗
Crossover trial found CBD normalized glutathione, glutamate, and GABA levels in AUD participants who drank the day before, but had no effect in those who abstained.
CBD Reduces Brain Activation in a Reward Region During Alcohol Cue Exposure ↗
Crossover fMRI trial found 800 mg CBD reduced precuneus activation during alcohol cue exposure in AUD participants, though craving and mood were unaffected.
Teens Find Cannabis Edible Packaging Appealing Despite Regulations ↗
Focus groups with 28 Washington teens found cannabis edible packaging appealing despite regulations, with cannabis-knowledgeable teens showing more skepticism.
Cannabichromene Killed Pancreatic Cancer Cells Through Multiple Cell Death Pathways ↗
Preclinical study found cannabichromene killed pancreatic cancer cells through multiple death pathways (apoptosis and ferroptosis) via TRPV1 and CB2 receptors, with tumor inhibition confirmed in mice.
Cannabis and Vaping Rose After Legalization, But Cigarette Use Did Not ↗
JAMA study of 55,406 adults over 5 years found cannabis legalization increased cannabis and e-cigarette use but did not affect cigarette smoking, with cannabis use rising more after retail outlets opened.
CBD-Rich Cannabis Extract Outperformed Pure CBD Against Brain Inflammation in Mice ↗
Mouse study found CBD-rich cannabis extract was more effective than pure synthetic CBD against brain inflammation, reducing anxiety, cognitive deficits, and oxidative stress.
Meta-Analysis Finds Cannabis Use Associated with Lower Oral Cancer Risk ↗
Meta-analysis of 6 studies with 15,000+ participants found marijuana use associated with 34% lower oral cancer risk, though authors caution about methodological limitations.
THC from Hemp-Fed Dairy Cows Transfers to Milk but Clears After Two Weeks ↗
Study found THC from hemp-fed dairy cows transfers to milk above safe levels, but a 12-day withdrawal period eliminates the risk for consumers.
Young Woman with No Heart Disease Had Cardiac Arrest After Chronic Cannabis Use ↗
A 26-year-old chronic cannabis user with no heart disease had a cardiac arrest with ventricular fibrillation and QTc prolongation, requiring prolonged rehabilitation for brain injury.
Low-Dose CBD Reduced Exercise-Induced Liver Enzyme Spikes in Athletes ↗
Crossover RCT found 60 mg/day CBD for 7 days blunted exercise-induced liver enzyme elevations in athletes without hepatotoxicity, with medium-to-large effect sizes.
What Every Parent Should Know About Teens and Cannabis in 2025 ↗
Teen cannabis use has held steady despite legalization, but ER visits, child ingestions, and product potency have all increased—changing the risk landscape.
Most Hand Surgery Patients Who Try CBD Do Not Find It Helpful ↗
Survey of 918 hand surgery patients found 15% had tried CBD, with only 39% of users reporting pain relief. CBD users had higher pain scores and worse function.
Suspected Cannabinoid Hyperemesis ER Visits Among Youth Rose 28% Per Year ↗
National ER data showed suspected CHS visits among youth (15-24) topped 55,000 from 2006-2020, with an average annual increase of 28.1%.
Cannabis Extracts Matched Pure CBD for Seizure Control in Zebrafish Despite Lower CBD Content ↗
Zebrafish epilepsy model found cannabis extracts matched pure CBD for seizure reduction despite containing much less CBD, supporting an entourage effect.
What Drives Same-Day Tobacco and Cannabis Use in Teens ↗
Study of 536 teen tobacco/cannabis users found alcohol use and secondhand smoke exposure were the strongest predictors of same-day poly-product use patterns.
Adverse Childhood Experiences Affect Substance Use Differently Across Racial Groups ↗
Study of 2,207 young adults found different types of adverse childhood experiences predicted different substance use patterns depending on racial/ethnic background.
College Students with OCD Have Higher Rates of Cannabis, Alcohol, and Tobacco Use ↗
Large study of 92,757 college students found OCD conditions independently associated with higher tobacco, cannabis, and alcohol use risk, plus more than doubled disordered eating risk.
Same-Day Nicotine and Cannabis Use Linked to Higher Dependence Symptoms in Teens ↗
Study of 3,823 high schoolers found same-day nicotine-cannabis use was associated with 4.28x higher odds of cannabis dependence symptoms versus using both but on different days.
Low Conscientiousness and High Open-Mindedness Linked to Cannabis Use Disorder ↗
Study of 1,335 psychiatric inpatients found low conscientiousness, low agreeableness, and high openness to experience associated with cannabis use disorder.
Synthetic Cannabinoids Make Fentanyl Overdoses Harder to Reverse with Naloxone ↗
Mouse study found synthetic cannabinoids combined with fentanyl worsened respiratory depression and made naloxone rescue less effective, explaining some naloxone-resistant overdoses.
CBD Reduced Anxiety and Brain Inflammation in Obese Aged Rats ↗
Aged obese rats given CBD showed reduced anxiety, lower circulating endotoxin, and decreased brain inflammation markers, with disrupted endocannabinoid signaling partially restored.
States with Legal Cannabis Saw More Asthma Hospitalizations ↗
Difference-in-differences analysis found states with cannabis dispensaries and legal recreational cannabis had 14-20% more asthma hospitalizations than comparison states.
Cannabis Legalization Linked to More Cannabis Use Disorder and Poisoning Diagnoses ↗
JAMA Psychiatry study of 110 million insured adults found medical cannabis laws associated with 31 more CUD diagnoses per 100,000 per quarter, with recreational laws linked to more cannabis poisoning.
Adding CBD to THC Actually Reduced Pain Relief in Rats with Inflammation ↗
Rat study found oral THC provided dose-dependent inflammatory pain relief (stronger in females), but adding CBD diminished THC's analgesic effects rather than enhancing them.