Most Hand Surgery Patients Who Try CBD Do Not Find It Helpful
Among 918 hand surgery patients, only 15% had used CBD, and just 39% of those reported any pain relief, with CBD users actually reporting higher pain and worse function.
Quick Facts
What This Study Found
15% of hand surgery patients (135/918) reported prior CBD use. Only 39% of CBD users (53/135) perceived pain relief. CBD users were more likely to be female (65% vs 51%), have wrist pathology (44% vs 35%), and have arthritis (36% vs 19%). CBD users reported significantly higher pain and worse function than non-users.
Key Numbers
918 patients surveyed (53% female, mean age 63). 15% (135/918) used CBD. 39% (53/135) of users reported pain relief. CBD users: 65% female vs 51% non-users (p=0.003). CBD users had higher arthritis rates (36% vs 19%, p<0.001).
How They Did This
Survey of 918 new patients at an orthopedic hand and upper extremity clinic (July-December 2022). Pain measured with Numeric Pain Rating Scale, function with Single Assessment Numeric Evaluation. Demographics and diagnoses from chart review.
Why This Research Matters
CBD products are widely marketed for pain, but this real-world clinic data suggests most hand/upper extremity patients who try CBD do not find it beneficial, and those who use it tend to have more severe conditions.
The Bigger Picture
The finding that CBD users had worse pain and function likely reflects that people with more severe conditions are more motivated to try CBD, rather than CBD worsening outcomes. Still, the low rate of perceived benefit challenges marketing claims.
What This Study Doesn't Tell Us
Cross-sectional design cannot determine if CBD caused, worsened, or failed to improve outcomes. CBD product type, dose, and duration of use were not standardized. Self-reported pain relief is subjective. Older patient population (mean 63) at a surgical clinic may not represent broader CBD users.
Questions This Raises
- ?Would standardized CBD dosing show better results than self-directed consumer use?
- ?Are certain hand conditions more responsive to CBD than others?
Trust & Context
- Key Stat:
- Only 39% of hand surgery patients who tried CBD reported any pain relief
- Evidence Grade:
- Large clinic-based survey but cross-sectional design with unstandardized CBD use limits conclusions about efficacy.
- Study Age:
- 2025 publication with data from July-December 2022.
- Original Title:
- Prevalence of Cannabidiol (CBD) Use in an Outpatient Hand Surgery Clinic.
- Published In:
- Orthopedics, 48(6), 329-335 (2025)
- Authors:
- Iturregui, Jose M, Deckey, David G(2), Ishimoto, Alyssa, Renfree, Sean P, Noland, Shelley S, Renfree, Kevin J
- Database ID:
- RTHC-06722
Evidence Hierarchy
Read More on RethinkTHC
- CBD-oil-quality-guide
- anxiety-medication-after-quitting-weed
- cannabis-chemotherapy-nausea
- cannabis-chronic-pain-research
- cannabis-epilepsy-CBD-Epidiolex
- cbd-anxiety-research-evidence
- cbd-for-weed-withdrawal
- cbd-vs-thc-difference
- medical-benefits-of-cannabis
- quitting-weed-before-surgery
- quitting-weed-medication-interactions
- quitting-weed-pregnancy
- quitting-weed-pregnant
- seniors-older-adults-cannabis-risks-medications
- weed-breastfeeding-THC-breast-milk
Cite This Study
https://rethinkthc.com/research/RTHC-06722APA
Iturregui, Jose M; Deckey, David G; Ishimoto, Alyssa; Renfree, Sean P; Noland, Shelley S; Renfree, Kevin J. (2025). Prevalence of Cannabidiol (CBD) Use in an Outpatient Hand Surgery Clinic.. Orthopedics, 48(6), 329-335. https://doi.org/10.3928/01477447-20250904-01
MLA
Iturregui, Jose M, et al. "Prevalence of Cannabidiol (CBD) Use in an Outpatient Hand Surgery Clinic.." Orthopedics, 2025. https://doi.org/10.3928/01477447-20250904-01
RethinkTHC
RethinkTHC Research Database. "Prevalence of Cannabidiol (CBD) Use in an Outpatient Hand Su..." RTHC-06722. Retrieved from https://rethinkthc.com/research/iturregui-2025-prevalence-of-cannabidiol-cbd
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.