CBD Isolate Survey: What Chronic Pain Users Report
In an anonymous survey, chronic pain sufferers using CBD isolate reported decreased pain even at low doses, with most noting no side effects.
Quick Facts
What This Study Found
Survey respondents using CBD isolate for chronic pain reported positive associations between CBD use and decreased chronic pain, even at doses under 100 mg. The majority reported no side effects, and no severe side effects were noted among any respondents.
Key Numbers
Positive association between CBD use and decreased chronic pain reported even at doses below 100 mg. Majority of respondents reported no side effects. No severe side effects reported by any participant.
How They Did This
Anonymous online Qualtrics survey posted publicly and in multiple medical clinics. Assessed CBD isolate use, perceived effectiveness, dosage, frequency, and side effects among adults with chronic pain.
Why This Research Matters
With up to 50 million U.S. adults affected by chronic pain and the ongoing opioid crisis, understanding how CBD users perceive its benefits and risks provides a starting point for more rigorous research.
The Bigger Picture
User surveys consistently show high satisfaction with CBD for pain, but placebo-controlled trials have produced mixed results. The gap between user perception and clinical evidence remains a key challenge for the field.
What This Study Doesn't Tell Us
Anonymous survey with no verification of CBD use, diagnoses, or outcomes. Self-selection bias: people satisfied with CBD are more likely to respond. No placebo comparison. CBD isolate products vary widely in actual content and quality.
Questions This Raises
- ?Would placebo-controlled trials confirm the low-dose efficacy reported by survey respondents?
- ?How does CBD isolate compare to full-spectrum CBD products for pain management?
Trust & Context
- Key Stat:
- Survey respondents reported pain relief from CBD isolate even at doses under 100 mg
- Evidence Grade:
- Anonymous self-report survey with no controls, verification, or standardized outcome measures. Subject to significant selection and reporting biases.
- Study Age:
- 2025 publication.
- Original Title:
- A Survey on the Use of Cannabidiol (CBD) Isolate, Its Perceived Benefits, and Associated Side Effects Among Subjects With Chronic Pain.
- Published In:
- Cureus, 17(3), e80198 (2025)
- Authors:
- Huang, Austin, Stolzenberg, Laurence, Usman, Mohammad, Awan, Muhammad, Bruner, Paul, MacGregor, Gordon
- Database ID:
- RTHC-06686
Evidence Hierarchy
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Cite This Study
https://rethinkthc.com/research/RTHC-06686APA
Huang, Austin; Stolzenberg, Laurence; Usman, Mohammad; Awan, Muhammad; Bruner, Paul; MacGregor, Gordon. (2025). A Survey on the Use of Cannabidiol (CBD) Isolate, Its Perceived Benefits, and Associated Side Effects Among Subjects With Chronic Pain.. Cureus, 17(3), e80198. https://doi.org/10.7759/cureus.80198
MLA
Huang, Austin, et al. "A Survey on the Use of Cannabidiol (CBD) Isolate, Its Perceived Benefits, and Associated Side Effects Among Subjects With Chronic Pain.." Cureus, 2025. https://doi.org/10.7759/cureus.80198
RethinkTHC
RethinkTHC Research Database. "A Survey on the Use of Cannabidiol (CBD) Isolate, Its Percei..." RTHC-06686. Retrieved from https://rethinkthc.com/research/huang-2025-a-survey-on-the
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.