Cannabis and Vaping Rose After Legalization, But Cigarette Use Did Not

Five years after recreational cannabis legalization, cannabis use increased by 3.28 percentage points and e-cigarette use by 1.39 points, while cigarette use did not significantly change.

Hyatt, Andrew S et al.·JAMA network open·2025·highlongitudinal cohort
RTHC-06706Longitudinal cohorthigh2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
longitudinal cohort
Evidence
high
Sample
N=171,257

What This Study Found

Using difference-in-differences analysis of 171,257 observations from 55,406 individuals, recreational cannabis legalization was associated with a 3.28 percentage point increase in cannabis use and 1.39 percentage point increase in ENDS use compared to control states. Cigarette use did not significantly change (-0.99 points). Cannabis use increased more after retail outlets opened (3.74 points) than before (1.17 points).

Key Numbers

171,257 observations from 55,406 individuals (50.9% female, mean age 37.97). Cannabis use: +3.28 pp (95% CI: 2.29-4.27). ENDS use: +1.39 pp (95% CI: 0.44-2.35). Cigarettes: -0.99 pp (95% CI: -2.25-0.27, not significant). Post-retail cannabis increase: +3.74 pp vs pre-retail +1.17 pp.

How They Did This

Difference-in-differences analysis of the nationally representative Population Assessment of Tobacco and Health (PATH) longitudinal cohort study (2013-2022), comparing states with recreational cannabis legalization to control states over 5 years.

Why This Research Matters

This is one of the first studies with enough follow-up to show longer-term effects of cannabis legalization on both cannabis and tobacco product use, using a rigorous causal inference design.

The Bigger Picture

The finding that legalization increases cannabis use but not cigarette use addresses a key policy concern. The unexpected increase in e-cigarette use suggests cross-product effects that regulators should monitor, potentially driven by vaping hardware crossover.

What This Study Doesn't Tell Us

Observational design despite difference-in-differences approach. State-level variation in implementation complicates uniform analysis. Self-reported use. Does not capture frequency or quantity changes within users. Cannot identify which individuals are new users versus increased users.

Questions This Raises

  • ?Why did e-cigarette use increase alongside cannabis legalization?
  • ?Does the post-retail acceleration of cannabis use plateau or continue climbing beyond 5 years?

Trust & Context

Key Stat:
Cannabis use rose 3.28 percentage points after legalization, accelerating to 3.74 points after retail outlets opened
Evidence Grade:
Large nationally representative longitudinal cohort with difference-in-differences design provides strong causal evidence. Published in JAMA Network Open.
Study Age:
2025 JAMA Network Open publication with 2013-2022 data.
Original Title:
Use of Tobacco and Cannabis Following State-Level Cannabis Legalization.
Published In:
JAMA network open, 8(7), e2520093 (2025)
Database ID:
RTHC-06706

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study
What do these levels mean? →

Read More on RethinkTHC

Cite This Study

RTHC-06706·https://rethinkthc.com/research/RTHC-06706

APA

Hyatt, Andrew S; Overhage, Lindsay; Cook, Benjamin Lê. (2025). Use of Tobacco and Cannabis Following State-Level Cannabis Legalization.. JAMA network open, 8(7), e2520093. https://doi.org/10.1001/jamanetworkopen.2025.20093

MLA

Hyatt, Andrew S, et al. "Use of Tobacco and Cannabis Following State-Level Cannabis Legalization.." JAMA network open, 2025. https://doi.org/10.1001/jamanetworkopen.2025.20093

RethinkTHC

RethinkTHC Research Database. "Use of Tobacco and Cannabis Following State-Level Cannabis L..." RTHC-06706. Retrieved from https://rethinkthc.com/research/hyatt-2025-use-of-tobacco-and

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.