About 1 in 10 Chronic Opioid Patients Tested Positive for THC

Among 244 urine drug screens from chronic opioid therapy patients, 9.8% tested positive for THC, with inconsistent clinical documentation and response to positive results.

Hasoon, Jamal et al.·Psychopharmacology bulletin·2025·Preliminary EvidenceRetrospective Cohort
RTHC-06643Retrospective CohortPreliminary Evidence2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Retrospective Cohort
Evidence
Preliminary Evidence
Sample
Not reported

What This Study Found

Of 244 urine drug screens from patients receiving chronic opioid therapy for pain at a single academic center (2024), 24 (9.8%) tested positive for THC. Provider responses to positive results varied widely: some documented patient counseling, others did not acknowledge the result. In a small subset, positive THC led to opioid therapy changes including tapering or discontinuation.

Key Numbers

244 urine screens; 24 (9.8%) THC-positive; variable provider documentation and response; some opioid therapy changes in small subset

How They Did This

Retrospective review of 244 urine drug screen results from chronic opioid therapy patients at a single academic institution (January-December 2024). Assessed THC positivity prevalence and documented provider responses.

Why This Research Matters

Nearly 10% of chronic opioid patients are concurrently using cannabis, often without their provider's knowledge. The inconsistent clinical response to positive THC screens highlights a need for standardized, non-punitive approaches to concurrent cannabis use in pain management.

The Bigger Picture

As cannabis legalization expands, the intersection of cannabis use and opioid prescribing requires clearer clinical guidelines. Punitive responses (stopping opioids) may drive patients to hide cannabis use, while ignoring positive screens misses an opportunity for risk assessment.

What This Study Doesn't Tell Us

Single institution with small sample. Retrospective review cannot capture provider reasoning. Cannot determine whether THC use was medical or recreational. 2024 data from a single year. Provider response documentation may not reflect actual conversations.

Questions This Raises

  • ?Should concurrent cannabis use change opioid prescribing decisions?
  • ?Would standardized protocols for positive THC screens in opioid patients improve care consistency?

Trust & Context

Key Stat:
Evidence Grade:
Preliminary: small single-site retrospective review without comparison group or outcome assessment.
Study Age:
2025 publication using 2024 data
Original Title:
Prevalence of THC-Positive Urine Drug Screens in Patients Receiving Chronic Opioid Therapy: A Retrospective Review.
Published In:
Psychopharmacology bulletin, 55(4), 36-42 (2025)
Database ID:
RTHC-06643

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-ControlFollows or compares groups over time
This study
Cross-Sectional / Observational
Case Report / Animal Study

Looks back at existing records to find patterns.

What do these levels mean? →

Read More on RethinkTHC

Cite This Study

RTHC-06643·https://rethinkthc.com/research/RTHC-06643

APA

Hasoon, Jamal; Viswanath, Omar; Urits, Ivan; Abd-Elsayed, Alaa; Kaye, Alan D. (2025). Prevalence of THC-Positive Urine Drug Screens in Patients Receiving Chronic Opioid Therapy: A Retrospective Review.. Psychopharmacology bulletin, 55(4), 36-42. https://doi.org/10.64719/pb.4549

MLA

Hasoon, Jamal, et al. "Prevalence of THC-Positive Urine Drug Screens in Patients Receiving Chronic Opioid Therapy: A Retrospective Review.." Psychopharmacology bulletin, 2025. https://doi.org/10.64719/pb.4549

RethinkTHC

RethinkTHC Research Database. "Prevalence of THC-Positive Urine Drug Screens in Patients Re..." RTHC-06643. Retrieved from https://rethinkthc.com/research/hasoon-2025-prevalence-of-thcpositive-urine

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.