About 1 in 10 Chronic Opioid Patients Tested Positive for THC
Among 244 urine drug screens from chronic opioid therapy patients, 9.8% tested positive for THC, with inconsistent clinical documentation and response to positive results.
Quick Facts
What This Study Found
Of 244 urine drug screens from patients receiving chronic opioid therapy for pain at a single academic center (2024), 24 (9.8%) tested positive for THC. Provider responses to positive results varied widely: some documented patient counseling, others did not acknowledge the result. In a small subset, positive THC led to opioid therapy changes including tapering or discontinuation.
Key Numbers
244 urine screens; 24 (9.8%) THC-positive; variable provider documentation and response; some opioid therapy changes in small subset
How They Did This
Retrospective review of 244 urine drug screen results from chronic opioid therapy patients at a single academic institution (January-December 2024). Assessed THC positivity prevalence and documented provider responses.
Why This Research Matters
Nearly 10% of chronic opioid patients are concurrently using cannabis, often without their provider's knowledge. The inconsistent clinical response to positive THC screens highlights a need for standardized, non-punitive approaches to concurrent cannabis use in pain management.
The Bigger Picture
As cannabis legalization expands, the intersection of cannabis use and opioid prescribing requires clearer clinical guidelines. Punitive responses (stopping opioids) may drive patients to hide cannabis use, while ignoring positive screens misses an opportunity for risk assessment.
What This Study Doesn't Tell Us
Single institution with small sample. Retrospective review cannot capture provider reasoning. Cannot determine whether THC use was medical or recreational. 2024 data from a single year. Provider response documentation may not reflect actual conversations.
Questions This Raises
- ?Should concurrent cannabis use change opioid prescribing decisions?
- ?Would standardized protocols for positive THC screens in opioid patients improve care consistency?
Trust & Context
- Key Stat:
- Evidence Grade:
- Preliminary: small single-site retrospective review without comparison group or outcome assessment.
- Study Age:
- 2025 publication using 2024 data
- Original Title:
- Prevalence of THC-Positive Urine Drug Screens in Patients Receiving Chronic Opioid Therapy: A Retrospective Review.
- Published In:
- Psychopharmacology bulletin, 55(4), 36-42 (2025)
- Authors:
- Hasoon, Jamal, Viswanath, Omar(3), Urits, Ivan(3), Abd-Elsayed, Alaa, Kaye, Alan D
- Database ID:
- RTHC-06643
Evidence Hierarchy
Looks back at existing records to find patterns.
What do these levels mean? →Read More on RethinkTHC
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Cite This Study
https://rethinkthc.com/research/RTHC-06643APA
Hasoon, Jamal; Viswanath, Omar; Urits, Ivan; Abd-Elsayed, Alaa; Kaye, Alan D. (2025). Prevalence of THC-Positive Urine Drug Screens in Patients Receiving Chronic Opioid Therapy: A Retrospective Review.. Psychopharmacology bulletin, 55(4), 36-42. https://doi.org/10.64719/pb.4549
MLA
Hasoon, Jamal, et al. "Prevalence of THC-Positive Urine Drug Screens in Patients Receiving Chronic Opioid Therapy: A Retrospective Review.." Psychopharmacology bulletin, 2025. https://doi.org/10.64719/pb.4549
RethinkTHC
RethinkTHC Research Database. "Prevalence of THC-Positive Urine Drug Screens in Patients Re..." RTHC-06643. Retrieved from https://rethinkthc.com/research/hasoon-2025-prevalence-of-thcpositive-urine
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.