Brief Interventions in Medical Settings Did Not Reduce Cannabis Use

A meta-analysis of 17 RCTs found no evidence that brief drug interventions delivered in general medical settings reduced cannabis use, consumption levels, or severity, though emergency department delivery showed some promise.

Berny, Lauren M et al.·Prevention science : the official journal of the Society for Prevention Research·2025·Strong EvidenceMeta-Analysis
RTHC-06056Meta AnalysisStrong Evidence2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Meta-Analysis
Evidence
Strong Evidence
Sample
N=17

What This Study Found

Across 17 RCTs, brief drug interventions showed no significant short-term effects on cannabis use (OR=1.20), consumption level (g=0.01), or severity (g=0.13). Long-term effects were also non-significant. However, sensitivity analyses found that interventions delivered specifically in emergency departments showed small but significant reductions in long-term cannabis consumption.

Key Numbers

17 RCTs synthesized. Short-term cannabis use: OR=1.20 (NS). Short-term consumption: g=0.01 (NS). Short-term severity: g=0.13 (NS). Long-term use: OR=1.19 (NS). Long-term consumption: g=0.04 (NS). ED-delivered interventions showed small significant long-term effect.

How They Did This

Systematic review and meta-analysis of 17 randomized controlled trials comparing brief drug interventions to control conditions in general medical settings. Mixed effects meta-regression examined variability across intervention characteristics including booster sessions, delivery setting, target, and population.

Why This Research Matters

Brief interventions work well for alcohol, so they have been widely adapted for cannabis. This meta-analysis shows they are not effective for cannabis in most medical settings, redirecting efforts toward settings (like EDs) where they may work.

The Bigger Picture

The assumption that what works for alcohol will work for cannabis does not hold for brief interventions. Cannabis use may require different intervention approaches, or may respond better in specific settings like emergency departments where motivation for change is higher.

What This Study Doesn't Tell Us

Heterogeneity in intervention designs across studies. Some trials had small sample sizes. Could not fully assess all potential moderators. The ED finding came from sensitivity analyses and needs confirmation.

Questions This Raises

  • ?Why do brief interventions work for alcohol but not cannabis?
  • ?What makes emergency departments a more effective setting?
  • ?What alternative intervention approaches should be developed?

Trust & Context

Key Stat:
No significant effect of brief interventions on cannabis use across 17 RCTs
Evidence Grade:
Strong: meta-analysis of 17 randomized controlled trials with sensitivity analyses and moderation testing
Study Age:
Published in 2025
Original Title:
Brief Drug Interventions Delivered in General Medical Settings: a Systematic Review and Meta-analysis of Cannabis Use Outcomes.
Published In:
Prevention science : the official journal of the Society for Prevention Research, 26(6), 985-998 (2025)
Database ID:
RTHC-06056

Evidence Hierarchy

Meta-Analysis / Systematic ReviewCombines many studies into one answer
This study
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / Observational
Case Report / Animal Study

Combines results from multiple studies to find an overall pattern.

What do these levels mean? →

Frequently Asked Questions

Don't brief interventions work for substance use?

They work well for alcohol, but this meta-analysis found no evidence they reduce cannabis use, consumption, or severity when delivered in general medical settings. The finding that ED-based interventions showed some promise suggests the setting matters.

Should doctors still screen for cannabis use?

Screening can still identify people who may benefit from more intensive interventions. However, the brief counseling that typically follows screening does not appear effective for cannabis on its own. Alternative approaches may be needed.

Read More on RethinkTHC

Cite This Study

RTHC-06056·https://rethinkthc.com/research/RTHC-06056

APA

Berny, Lauren M; Nichols, Lindsey M; Schweer-Collins, Maria L; Tanner-Smith, Emily E. (2025). Brief Drug Interventions Delivered in General Medical Settings: a Systematic Review and Meta-analysis of Cannabis Use Outcomes.. Prevention science : the official journal of the Society for Prevention Research, 26(6), 985-998. https://doi.org/10.1007/s11121-025-01826-7

MLA

Berny, Lauren M, et al. "Brief Drug Interventions Delivered in General Medical Settings: a Systematic Review and Meta-analysis of Cannabis Use Outcomes.." Prevention science : the official journal of the Society for Prevention Research, 2025. https://doi.org/10.1007/s11121-025-01826-7

RethinkTHC

RethinkTHC Research Database. "Brief Drug Interventions Delivered in General Medical Settin..." RTHC-06056. Retrieved from https://rethinkthc.com/research/berny-2025-brief-drug-interventions-delivered

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.