Cannabis Use May Buffer Suicidal Ideation in Bullied LGBTQ+ Youth — But Opioids and Hallucinogens Increase Suicide Attempts

Among 96,482 youth, LGBTQ+ teens who were bullied and used cannabis were less likely to report suicidal ideation compared to bullied non-users, while opioid and hallucinogen use were associated with significantly higher suicide attempt rates.

Tiedge, Cayson W et al.·Prevention science : the official journal of the Society for Prevention Research·2025·Moderate EvidenceCross-Sectional
RTHC-07794Cross SectionalModerate Evidence2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Cross-Sectional
Evidence
Moderate Evidence
Sample
N=96,482

What This Study Found

Bullied LGBTQ+ youth had 2.71 times higher odds of planning suicide attempts. Opioid/prescription drug use increased attempt odds 4.6-fold, hallucinogen use 8.89-fold. No significant association between alcohol and STB. Unexpectedly, cannabis moderated the bullying-suicidality association: bullied youth who used cannabis were less likely to report suicidal ideation and planning than bullied non-users.

Key Numbers

96,482 youth from 2003-2019 YRBS. Bullied LGBTQ+ suicide planning: OR 2.71. Opioid use + attempt: OR 4.60. Hallucinogen use + attempt: OR 8.89. Cannabis moderated bullying-ideation link: lower suicidal ideation in bullied cannabis users vs. bullied non-users.

How They Did This

Cross-sectional analysis of combined 2003-2019 Youth Risk Behavior Survey (N=96,482). Hierarchical logistic regression examining interactions between bullying victimization, substance use (alcohol, cannabis, hallucinogens, opioids), and suicidal thoughts and behaviors in LGBTQ+ youth.

Why This Research Matters

This is one of the largest studies examining the intersection of bullying, substance use, and suicidality in LGBTQ+ youth. The cannabis finding is counterintuitive and important: while not endorsing cannabis use, it suggests some youth may use it as a coping mechanism that temporarily reduces suicidal thinking.

The Bigger Picture

The differential substance-suicide associations highlight that not all substance use carries the same risk. While opioids and hallucinogens amplify suicidality risk in bullied LGBTQ+ youth, cannabis may serve as a coping mechanism — though healthier alternatives should be developed.

What This Study Doesn't Tell Us

Cross-sectional YRBS data cannot establish causation. Self-reported bullying and substance use. Cannabis finding does not mean cannabis is therapeutic for suicidality — it may simply be a less harmful coping mechanism than other substances. Historical data (2003-2019) spans different cannabis eras.

Questions This Raises

  • ?Does cannabis serve as a harm-reduction coping mechanism for bullied LGBTQ+ youth?
  • ?Could targeted interventions replace substance-based coping in this population?

Trust & Context

Key Stat:
Evidence Grade:
Very large nationally representative dataset with adjusted analyses, but cross-sectional design and self-reported data limit causal conclusions. Cannabis finding is unexpected and requires replication.
Study Age:
2025 publication analyzing 2003-2019 YRBS data.
Original Title:
Understanding Suicidal Thoughts and Behaviors Among LGBTQ + Youth: Differential Associations Between Bullying and Substance Use.
Published In:
Prevention science : the official journal of the Society for Prevention Research, 26(3), 449-461 (2025)
Database ID:
RTHC-07794

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study

A snapshot of a population at one point in time.

What do these levels mean? →

Frequently Asked Questions

Does substance use affect suicide risk in LGBTQ+ youth?

Yes, but differently by substance. This study found opioid use increased suicide attempt risk 4.6-fold and hallucinogens 8.89-fold in bullied LGBTQ+ youth. Unexpectedly, cannabis use was associated with lower suicidal ideation among bullied youth, though this does not mean cannabis is a treatment for suicidality.

Why might cannabis reduce suicidal thinking in bullied teens?

The authors suggest cannabis may serve as a coping mechanism for bullied LGBTQ+ youth, temporarily reducing distress. However, this cross-sectional finding does not prove cannabis is therapeutic — healthier coping strategies should be the goal of prevention programs.

Read More on RethinkTHC

Cite This Study

RTHC-07794·https://rethinkthc.com/research/RTHC-07794

APA

Tiedge, Cayson W; Valido, Alberto; Rivas-Koehl, Matthew; Garcia, Brian A; Robinson, Luz E; Clements, Graceson; Espelage, Dorothy L. (2025). Understanding Suicidal Thoughts and Behaviors Among LGBTQ + Youth: Differential Associations Between Bullying and Substance Use.. Prevention science : the official journal of the Society for Prevention Research, 26(3), 449-461. https://doi.org/10.1007/s11121-025-01783-1

MLA

Tiedge, Cayson W, et al. "Understanding Suicidal Thoughts and Behaviors Among LGBTQ + Youth: Differential Associations Between Bullying and Substance Use.." Prevention science : the official journal of the Society for Prevention Research, 2025. https://doi.org/10.1007/s11121-025-01783-1

RethinkTHC

RethinkTHC Research Database. "Understanding Suicidal Thoughts and Behaviors Among LGBTQ + ..." RTHC-07794. Retrieved from https://rethinkthc.com/research/tiedge-2025-understanding-suicidal-thoughts-and

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.