Man Experienced Nine Days of Cognitive Impairment After Eating HHC-C9 Cannabis Cookies
A man in his early forties experienced nine days of cognitive and physical impairment after consuming cookies containing HHC-C9, a novel semisynthetic cannabinoid sold as a "legal high."
Quick Facts
What This Study Found
After eating two cannabis cookies labeled as containing 40 mg "CC9" and biting a gummy with unknown contents, a man in his early forties required emergency admission for deficits in alertness and responsiveness. He experienced vomiting, visual problems, and nine days of cognitive and physical impairment. Forensic toxicology confirmed HHC-C9, a novel semisynthetic cannabinoid.
Key Numbers
9 days of impairment. Two cookies consumed (labeled 40 mg CC9). Products often mislabeled and sold as souvenirs or potpourri. SSCs account for >40% of new substances at European level.
How They Did This
Single case report from an Emergency Department. Clinical presentation documented alongside forensic toxicological analysis confirming HHC-C9 in blood.
Why This Research Matters
Semisynthetic cannabinoids like HHC-C9 now account for over 40% of new psychoactive substances reported in Europe. They are sold as "legal highs" in convenience stores and online, often as cookies, candies, or vape products specifically targeting young consumers. This case demonstrates that their effects can be dramatically more severe and prolonged than natural cannabis.
The Bigger Picture
The proliferation of semisynthetic cannabinoids through legal loopholes creates a growing public health risk. These products are designed to mimic THC but can produce much stronger and longer-lasting effects. The nine-day impairment in this case far exceeds anything expected from natural cannabis, highlighting the unpredictability of these novel compounds.
What This Study Doesn't Tell Us
Single case report. Co-ingestion of gummy with unknown contents. Cannot determine exact dose consumed. Individual susceptibility may vary. Limited information on HHC-C9 pharmacology.
Questions This Raises
- ?How common are severe reactions to HHC-C9?
- ?Should emergency departments routinely test for semisynthetic cannabinoids?
- ?What regulatory approaches could address the rapid emergence of new synthetic variants?
Trust & Context
- Key Stat:
- 9 days of cognitive impairment
- Evidence Grade:
- Preliminary: single case report providing important clinical alert about a novel compound.
- Study Age:
- 2025 study
- Original Title:
- Long-Lasting Cognitive and Physical Impairment After Recreational Use of the Semisynthetic Cannabinoid Hexahydrocannabinonyl (HHC-C9): A Case Report.
- Published In:
- Reports (MDPI), 8(3) (2025)
- Authors:
- Reiter, Nanna, Palmqvist, Dorte Fris, Larsen, Gro Borges, Høi, Mathilde Emilie, Rasmussen, Brian Schou, Thomsen, Ragnar
- Database ID:
- RTHC-07466
Evidence Hierarchy
Describes what happened to one person or a small group.
What do these levels mean? →Frequently Asked Questions
What is HHC-C9?
It is a semisynthetic cannabinoid designed to mimic THC effects. It is sold in edible products like cookies and gummies, often marketed as a legal alternative to cannabis. This case shows its effects can be dramatically more severe and prolonged than natural cannabis.
Are "legal" cannabis cookies safe?
This case demonstrates they can cause serious, prolonged effects. The man experienced nine days of cognitive and physical impairment from products sold as legal alternatives. These products often bypass regulations by being mislabeled.
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Cite This Study
https://rethinkthc.com/research/RTHC-07466APA
Reiter, Nanna; Palmqvist, Dorte Fris; Larsen, Gro Borges; Høi, Mathilde Emilie; Rasmussen, Brian Schou; Thomsen, Ragnar. (2025). Long-Lasting Cognitive and Physical Impairment After Recreational Use of the Semisynthetic Cannabinoid Hexahydrocannabinonyl (HHC-C9): A Case Report.. Reports (MDPI), 8(3). https://doi.org/10.3390/reports8030176
MLA
Reiter, Nanna, et al. "Long-Lasting Cognitive and Physical Impairment After Recreational Use of the Semisynthetic Cannabinoid Hexahydrocannabinonyl (HHC-C9): A Case Report.." Reports (MDPI), 2025. https://doi.org/10.3390/reports8030176
RethinkTHC
RethinkTHC Research Database. "Long-Lasting Cognitive and Physical Impairment After Recreat..." RTHC-07466. Retrieved from https://rethinkthc.com/research/reiter-2025-longlasting-cognitive-and-physical
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.