Brain Science App Reduced Cannabis Use and Improved Decision-Making in College Students

A neuroscience-based mobile app reduced cannabis use intentions and actual use while improving executive function, metacognition, and decision-making in 68 college students.

Rezapour, Tara et al.·Frontiers in psychiatry·2025·Preliminary EvidencePilot Study
RTHC-07471Pilot StudyPreliminary Evidence2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Pilot Study
Evidence
Preliminary Evidence
Sample
N=68

What This Study Found

After four 20-minute NIPA sessions, 68 college students showed significant reductions in executive function deficits, stress, and anxiety. Decision-making improved: reduced delay discounting of large rewards and increased sensitivity to uncertainty. Participants reported lower intentions to use and lower actual use of nicotine and cannabis, and less binge drinking.

Key Numbers

68 participants. Four 20-minute sessions. Significant reductions in executive function deficits (Z=-7.11, p<0.001). Reduced anxiety (Z=-2.49, p=0.013). Increased metacognitive awareness (Z=-3.07, p=0.002). Reduced cannabis use intentions and actual use.

How They Did This

Pilot study with 68 undergraduates who had prior substance use. Pre-post assessment around four 20-minute NIPA app sessions combining metacognitive training, gamified neurocognitive tasks, and neuroscience psychoeducation delivered through cartoons, animations, and videos. Wilcoxon signed-rank and binomial tests analyzed changes.

Why This Research Matters

Traditional substance prevention focuses on knowledge and motivation, but this app targets underlying cognitive processes like executive function and decision-making. The simultaneous improvement in cognition and reduction in substance use suggests that building cognitive skills may be more effective than information alone.

The Bigger Picture

If cognitive training can reduce substance use, it offers a scalable, non-stigmatizing prevention approach. The app format makes it accessible and engaging for college students, and the neuroscience framing may be more appealing than traditional prevention messaging.

What This Study Doesn't Tell Us

No control group. Pre-post design cannot establish causation. Small sample (N=68). Very short intervention (4 sessions). No follow-up to assess durability. Self-reported outcomes. Participants self-selected.

Questions This Raises

  • ?Would effects persist with longer follow-up?
  • ?Would a randomized trial with control group confirm the findings?
  • ?Which components of the app drive the cognitive and behavioral changes?

Trust & Context

Key Stat:
Reduced cannabis use after 4 app sessions
Evidence Grade:
Preliminary: promising pilot results but no control group, small sample, and no follow-up assessment.
Study Age:
2025 study
Original Title:
Efficacy of a neuroscience informed psychoeducation intervention on cognitive, emotional, and substance use outcomes in college students: a pilot study.
Published In:
Frontiers in psychiatry, 16, 1655909 (2025)
Database ID:
RTHC-07471

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study

A small preliminary study to test whether a larger study is feasible.

What do these levels mean? →

Frequently Asked Questions

Can a phone app help reduce cannabis use?

This pilot study showed promising results: after four 20-minute sessions of a neuroscience-based app, college students reported lower cannabis use and intentions to use, along with improved cognitive skills.

How does the app work?

The NIPA app uses cartoons, animations, and gamified cognitive tasks to teach users about how substances affect their brain, while simultaneously training executive function and decision-making skills.

Read More on RethinkTHC

Cite This Study

RTHC-07471·https://rethinkthc.com/research/RTHC-07471

APA

Rezapour, Tara; McLean, Kayla L; Psederska, Elena; Chokshi, Swara; Maleki, Khashayar Niki; Ekhtiari, Hamed; Vassileva, Jasmin. (2025). Efficacy of a neuroscience informed psychoeducation intervention on cognitive, emotional, and substance use outcomes in college students: a pilot study.. Frontiers in psychiatry, 16, 1655909. https://doi.org/10.3389/fpsyt.2025.1655909

MLA

Rezapour, Tara, et al. "Efficacy of a neuroscience informed psychoeducation intervention on cognitive, emotional, and substance use outcomes in college students: a pilot study.." Frontiers in psychiatry, 2025. https://doi.org/10.3389/fpsyt.2025.1655909

RethinkTHC

RethinkTHC Research Database. "Efficacy of a neuroscience informed psychoeducation interven..." RTHC-07471. Retrieved from https://rethinkthc.com/research/rezapour-2025-efficacy-of-a-neuroscience

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.