Brain Science App Reduced Cannabis Use and Improved Decision-Making in College Students
A neuroscience-based mobile app reduced cannabis use intentions and actual use while improving executive function, metacognition, and decision-making in 68 college students.
Quick Facts
What This Study Found
After four 20-minute NIPA sessions, 68 college students showed significant reductions in executive function deficits, stress, and anxiety. Decision-making improved: reduced delay discounting of large rewards and increased sensitivity to uncertainty. Participants reported lower intentions to use and lower actual use of nicotine and cannabis, and less binge drinking.
Key Numbers
68 participants. Four 20-minute sessions. Significant reductions in executive function deficits (Z=-7.11, p<0.001). Reduced anxiety (Z=-2.49, p=0.013). Increased metacognitive awareness (Z=-3.07, p=0.002). Reduced cannabis use intentions and actual use.
How They Did This
Pilot study with 68 undergraduates who had prior substance use. Pre-post assessment around four 20-minute NIPA app sessions combining metacognitive training, gamified neurocognitive tasks, and neuroscience psychoeducation delivered through cartoons, animations, and videos. Wilcoxon signed-rank and binomial tests analyzed changes.
Why This Research Matters
Traditional substance prevention focuses on knowledge and motivation, but this app targets underlying cognitive processes like executive function and decision-making. The simultaneous improvement in cognition and reduction in substance use suggests that building cognitive skills may be more effective than information alone.
The Bigger Picture
If cognitive training can reduce substance use, it offers a scalable, non-stigmatizing prevention approach. The app format makes it accessible and engaging for college students, and the neuroscience framing may be more appealing than traditional prevention messaging.
What This Study Doesn't Tell Us
No control group. Pre-post design cannot establish causation. Small sample (N=68). Very short intervention (4 sessions). No follow-up to assess durability. Self-reported outcomes. Participants self-selected.
Questions This Raises
- ?Would effects persist with longer follow-up?
- ?Would a randomized trial with control group confirm the findings?
- ?Which components of the app drive the cognitive and behavioral changes?
Trust & Context
- Key Stat:
- Reduced cannabis use after 4 app sessions
- Evidence Grade:
- Preliminary: promising pilot results but no control group, small sample, and no follow-up assessment.
- Study Age:
- 2025 study
- Original Title:
- Efficacy of a neuroscience informed psychoeducation intervention on cognitive, emotional, and substance use outcomes in college students: a pilot study.
- Published In:
- Frontiers in psychiatry, 16, 1655909 (2025)
- Authors:
- Rezapour, Tara, McLean, Kayla L, Psederska, Elena, Chokshi, Swara, Maleki, Khashayar Niki, Ekhtiari, Hamed, Vassileva, Jasmin
- Database ID:
- RTHC-07471
Evidence Hierarchy
A small preliminary study to test whether a larger study is feasible.
What do these levels mean? →Frequently Asked Questions
Can a phone app help reduce cannabis use?
This pilot study showed promising results: after four 20-minute sessions of a neuroscience-based app, college students reported lower cannabis use and intentions to use, along with improved cognitive skills.
How does the app work?
The NIPA app uses cartoons, animations, and gamified cognitive tasks to teach users about how substances affect their brain, while simultaneously training executive function and decision-making skills.
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Cite This Study
https://rethinkthc.com/research/RTHC-07471APA
Rezapour, Tara; McLean, Kayla L; Psederska, Elena; Chokshi, Swara; Maleki, Khashayar Niki; Ekhtiari, Hamed; Vassileva, Jasmin. (2025). Efficacy of a neuroscience informed psychoeducation intervention on cognitive, emotional, and substance use outcomes in college students: a pilot study.. Frontiers in psychiatry, 16, 1655909. https://doi.org/10.3389/fpsyt.2025.1655909
MLA
Rezapour, Tara, et al. "Efficacy of a neuroscience informed psychoeducation intervention on cognitive, emotional, and substance use outcomes in college students: a pilot study.." Frontiers in psychiatry, 2025. https://doi.org/10.3389/fpsyt.2025.1655909
RethinkTHC
RethinkTHC Research Database. "Efficacy of a neuroscience informed psychoeducation interven..." RTHC-07471. Retrieved from https://rethinkthc.com/research/rezapour-2025-efficacy-of-a-neuroscience
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.