Pediatricians' Guide to Cannabis in Adolescents: Screening, Syndromes, and Treatment

A clinical review found less than 20% of U.S. youth currently use cannabis, with lifetime use actually decreasing over recent decades, while providing pediatricians with updated guidance on screening and treatment.

Rabinow, Lily et al.·Pediatrics in review·2025·Moderate EvidenceReview
RTHC-07422ReviewModerate Evidence2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Review
Evidence
Moderate Evidence
Sample
Not reported

What This Study Found

Despite increasing adult cannabis use and higher-THC products, longitudinal studies show less than 20% of youth report current cannabis use and lifetime use has actually decreased over recent decades. The review covers acute and chronic clinical syndromes, evidence-based screening tools, and treatment modalities specific to adolescents.

Key Numbers

Less than 20% of youth report current use. Lifetime use has decreased over recent decades. Almost half of U.S. states have legalized recreational adult use.

How They Did This

Clinical review published in Pediatrics in Review covering cannabis formulations, THC concentration variations, epidemiological trends in youth use, clinical syndromes (acute and chronic), evidence-based screening tools, and treatment approaches for adolescent cannabis use.

Why This Research Matters

The perception that teen cannabis use is exploding does not match the data. While more potent products are available and adult use has risen, adolescent use has not followed the same trajectory. This nuanced picture helps pediatricians calibrate their responses and focus on evidence-based screening and intervention.

The Bigger Picture

The disconnect between rising adult legalization and stable or declining youth use suggests that regulatory frameworks may be effectively limiting youth access, or that other social factors are at play. However, the increasing potency of available products means that youth who do use may face greater risks per use episode.

What This Study Doesn't Tell Us

Narrative clinical review without systematic methodology. Relies on existing epidemiological surveys that may have limitations. U.S.-focused. Does not quantify the impact of higher-potency products on the subset of youth who do use.

Questions This Raises

  • ?Are youth who use cannabis today exposed to more risk per episode due to higher potency?
  • ?Do current screening tools adequately capture emerging routes of use like vaping and dabbing?
  • ?How should pediatrician messaging adapt as more states legalize?

Trust & Context

Key Stat:
Youth lifetime use has decreased over decades
Evidence Grade:
Moderate: published in a peer-reviewed clinical review journal drawing on epidemiological data, though not a systematic review.
Study Age:
2025 study
Original Title:
Cannabis Use in Adolescents.
Published In:
Pediatrics in review, 46(9), 482-493 (2025)
Database ID:
RTHC-07422

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study

Summarizes existing research on a topic.

What do these levels mean? →

Frequently Asked Questions

Is teen cannabis use increasing with legalization?

Despite increasing adult legalization and availability, longitudinal studies show less than 20% of youth currently use cannabis and lifetime use has actually decreased over recent decades.

What should pediatricians know about cannabis?

The review covers different product formulations, varying THC concentrations, how to screen for use, common clinical syndromes to watch for, and evidence-based treatment approaches for adolescents.

Read More on RethinkTHC

Cite This Study

RTHC-07422·https://rethinkthc.com/research/RTHC-07422

APA

Rabinow, Lily; Dries, Emily; Hoffman, Neal D. (2025). Cannabis Use in Adolescents.. Pediatrics in review, 46(9), 482-493. https://doi.org/10.1542/pir.2024-006514

MLA

Rabinow, Lily, et al. "Cannabis Use in Adolescents.." Pediatrics in review, 2025. https://doi.org/10.1542/pir.2024-006514

RethinkTHC

RethinkTHC Research Database. "Cannabis Use in Adolescents." RTHC-07422. Retrieved from https://rethinkthc.com/research/rabinow-2025-cannabis-use-in-adolescents

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.