Cannabis Use Linked to Increased Risk of Heart Rhythm Problems, Especially in Young Men

Epidemiological data show a significant association between cannabis use and various arrhythmias, particularly atrial fibrillation. The risk is notably higher among younger users and males. Case reports have linked cannabis to ventricular tachycardia and ventricular fibrillation, especially in people with underlying heart conditions. Synthetic cannabinoids carry even greater arrhythmogenic risk due to higher potency.

Comprehensive narrative review of the arrhythmogenic properties of cannabis and synthetic cannabinoids, examining epidemiological studies, case reports, and mechanistic evidence related to the endocannabinoid system and cardiac electrophysiology.

With an estimated 219 million cannabis users globally and THC concentrations in products increasing over time, the cardiovascular safety profile of cannabis deserves more attention. This review synthesizes evidence that cannabis can disrupt heart rhythm, particularly in populations often assumed to be at low cardiac risk.

As cannabis potency increases and new products proliferate, understanding cardiac risks becomes more urgent. The review notes that people with channelopathies, structural heart disease, or prior heart attack may be at particular risk, a finding relevant to both recreational users and those considering medicinal cannabis.

Narrative review rather than systematic review with meta-analysis. Some studies found no significant difference in arrhythmia burden between users and non-users. Much evidence comes from case reports rather than controlled studies. Cannot establish definitive causation.