In the first study to measure THC in human semen, researchers detected the compound in some chronic cannabis users, showing THC can cross the blood-testis barrier.
Reproductive endocrinologists, fertility specialists, and couples trying to conceive.
First detection of THC in human semen; correlated with blood levels (r=0.66)
What the researchers found
Among 12 heavy cannabis users, THC was detectable above reporting levels (0.50 ng/mL) in 2 of 10 analyzable semen samples. Seminal THC was moderately correlated with serum THC levels (r=0.66). Notably, semen parameters (concentration, motility, morphology) were within normal ranges despite heavy cannabis use, though prolactin was elevated in half the participants.
Why it matters
This is the first demonstration that THC crosses the blood-testis barrier in humans. This has implications for understanding potential effects on sperm function and reproductive outcomes.
The numbers in context
12 participants; THC detected in semen of 2/10 samples; moderate correlation with serum THC (r=0.66); median sperm concentration 75.5M/mL, motility 69.5%, morphology 5.5% (all normal); prolactin elevated in 6/12.
How the study worked
Proof-of-concept study with 12 healthy men aged 18-45 who were chronic heavy users of inhaled cannabis. THC and metabolites measured in serum, urine, and semen using LC-MS/MS. Standard semen analysis performed.
What this study cannot tell us
Very small sample (n=12, only 10 analyzable); THC only detectable above threshold in 2 samples; no comparison with non-users; single time point; cannot determine functional significance of seminal THC.
How to read the evidence
Preliminary: very small proof-of-concept study; THC only detected in 2 of 10 samples.
When this study was published
Published 2020.
The bigger picture
If THC is present in the reproductive tract, it could potentially affect sperm function or early embryo development. This proof-of-concept opens a new area of investigation in reproductive toxicology.
Questions still open
- Does seminal THC affect sperm function or fertilization? Could THC in semen affect embryo development?
Common questions
Does cannabis affect semen quality?
What does THC in semen mean for fertility?
Read the original research
Delta-9 THC can be detected and quantified in the semen of men who are chronic users of inhaled cannabis.
Journal of assisted reproduction and genetics, 37(6), 1497-1504
Citation
Lee, Malinda S; Lanes, Andrea; Ginsburg, Elizabeth S; Fox, Janis H. (2020). Delta-9 THC can be detected and quantified in the semen of men who are chronic users of inhaled cannabis.. Journal of assisted reproduction and genetics, 37(6), 1497-1504. https://doi.org/10.1007/s10815-020-01762-1
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