Argentine ER study finds alcohol and combined alcohol-cannabis use dramatically increase road traffic injury risk

Among 306 injured emergency department patients in Argentina, alcohol increased road traffic injury risk nearly 7-fold, and combined alcohol-cannabis use showed similar risk, with passengers facing the highest risk from alcohol.

Conde, Karina et al.·Revista panamericana de salud publica = Pan American journal of public health·2022·Moderate EvidenceCase-Control
RTHC-03769Case ControlModerate Evidence2022RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Case-Control
Evidence
Moderate Evidence
Sample
N=306

What This Study Found

Alcohol use increased road traffic injury risk 6.78-fold (95% CI 3.75-12.25). Combined alcohol and cannabis use increased risk 7.05-fold (95% CI 1.16-42.73). Passengers had the highest alcohol-related risk (OR 13.83). The combined alcohol-cannabis risk was significant only for those under 30. Cannabis alone was not separately analyzed due to insufficient cases.

Key Numbers

N=306; alcohol OR=6.78; combined alcohol+cannabis OR=7.05; women OR=8.87; men OR=6.16; passengers OR=13.83; under 30 with combined use OR=7.05.

How They Did This

Case-crossover study of 306 injured emergency department patients in Mar del Plata, Argentina. Each patient served as their own control, comparing substance use at the time of injury to their typical use patterns.

Why This Research Matters

These are the first road traffic injury risk estimates for alcohol and cannabis in the Southern Cone of South America, providing data relevant to impaired driving policy in a region where cannabis legalization is advancing.

The Bigger Picture

The finding that combined alcohol-cannabis risk was significant only for those under 30 highlights young adults as a particularly vulnerable group for polysubstance-impaired driving.

What This Study Doesn't Tell Us

Relatively small sample. Wide confidence intervals for combined alcohol-cannabis risk. Cannabis alone not separately analyzed. Self-report of substance use. Single hospital in one city.

Questions This Raises

  • ?What is the independent risk of cannabis alone for road traffic injury in this population?
  • ?Would the combined risk be different in a larger sample?
  • ?How should impaired driving laws address polysubstance use?

Trust & Context

Key Stat:
Alcohol: 6.8x risk; alcohol + cannabis: 7.1x risk for road injury
Evidence Grade:
Case-crossover design reduces confounding but small sample and wide confidence intervals limit precision.
Study Age:
Published in 2022.
Original Title:
Road traffic injury risk from alcohol and cannabis use among emergency department patients in Argentina.
Published In:
Revista panamericana de salud publica = Pan American journal of public health, 46, e116 (2022)
Database ID:
RTHC-03769

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-ControlFollows or compares groups over time
This study
Cross-Sectional / Observational
Case Report / Animal Study

Compares people with a condition to similar people without it.

What do these levels mean? →

Frequently Asked Questions

How much does alcohol increase road accident risk?

In this study, alcohol use increased road traffic injury risk nearly 7 times. Passengers in vehicles with alcohol-using drivers had an even higher risk (nearly 14 times).

Is combining alcohol and cannabis more dangerous for driving?

Combined alcohol and cannabis use showed a 7-fold increase in road traffic injury risk, similar to alcohol alone. However, this combined risk was only significant for people under 30.

Read More on RethinkTHC

Cite This Study

RTHC-03769·https://rethinkthc.com/research/RTHC-03769

APA

Conde, Karina; Peltzer, Raquel Inés; Gimenez, Paula Victoria; Salomón, Tomás; Suarez, Gabriel; Monteiro, Maristela; Cherpitel, Cheryl J; Cremonte, Mariana. (2022). Road traffic injury risk from alcohol and cannabis use among emergency department patients in Argentina.. Revista panamericana de salud publica = Pan American journal of public health, 46, e116. https://doi.org/10.26633/RPSP.2022.116

MLA

Conde, Karina, et al. "Road traffic injury risk from alcohol and cannabis use among emergency department patients in Argentina.." Revista panamericana de salud publica = Pan American journal of public health, 2022. https://doi.org/10.26633/RPSP.2022.116

RethinkTHC

RethinkTHC Research Database. "Road traffic injury risk from alcohol and cannabis use among..." RTHC-03769. Retrieved from https://rethinkthc.com/research/conde-2022-road-traffic-injury-risk

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.