Review of 170 articles maps CBD's anti-inflammatory and neuroprotective mechanisms, proposing metabolomics as the next frontier.
Neuroscience researchers and clinicians considering CBD.
170 articles reviewed across neurological and neuropsychiatric conditions
What the researchers found
CBD antagonizes pro-inflammatory cytokines, regulates oxidative stress, downregulates TNF-alpha, restores BDNF and serotonin across neurological disorders.
Why it matters
Maps CBD mechanisms across brain disorders in one reference; proposes metabolomics for personalized therapy.
The numbers in context
170 articles (41% of screened); TNF-alpha downregulation, BDNF restoration, serotonin recovery
How the study worked
Narrative review of 170 articles (41% of screened) from PubMed, Web of Science, and Scopus.
What this study cannot tell us
Narrative review. Mostly preclinical. No new data. Breadth limits depth.
How to read the evidence
Broad narrative review of mostly preclinical evidence.
When this study was published
Published in 2024.
The bigger picture
Translating preclinical CBD findings into clinical treatments remains the challenge.
Questions still open
- Can metabolomics predict CBD response?
- Which conditions have strongest clinical CBD evidence?
Common questions
How does CBD fight brain inflammation?
What is metabolomics?
Read the original research
A narrative review of the therapeutic and remedial prospects of cannabidiol with emphasis on neurological and neuropsychiatric disorders.
Journal of cannabis research, 6(1), 14
Citation
Omotayo, Oluwadara Pelumi; Lemmer, Yolandy; Mason, Shayne. (2024). A narrative review of the therapeutic and remedial prospects of cannabidiol with emphasis on neurological and neuropsychiatric disorders.. Journal of cannabis research, 6(1), 14. https://doi.org/10.1186/s42238-024-00222-2
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