A review found growing evidence that topical CBD has anti-inflammatory, anti-itch, analgesic, wound healing, and anti-proliferative effects on skin through cannabinoid receptors.
Dermatologists, people with chronic skin conditions, CBD product researchers
Cannabinoid receptors found on skin cells
What the researchers found
With the discovery of cannabinoid receptors on the skin, topical cannabis has demonstrated anti-inflammatory, anti-itching, analgesic, wound healing, and anti-proliferative effects. CBD is being explored as a potential alternative to topical corticosteroids for some dermatological conditions.
Why it matters
Topical corticosteroids are the mainstay treatment for many skin conditions but carry significant side effects with long-term use. Topical CBD could offer a safer alternative if clinical evidence supports it.
The numbers in context
Over 500 biologically active components in cannabis; over 100 phytocannabinoids identified; 3 primary cannabis species (sativa, indica, ruderalis)
How the study worked
Comprehensive review of literature on topical CBD for dermatological applications, covering the endocannabinoid system in skin, cannabinoid receptor distribution, and evidence for specific skin conditions.
What this study cannot tell us
Review primarily describes mechanisms and rationale rather than clinical trial results. Most evidence comes from preclinical or early-stage studies.
How to read the evidence
Review of predominantly preclinical evidence. Clinical trial data for topical CBD in dermatology remains limited.
When this study was published
Published in 2022
The bigger picture
The skin has its own endocannabinoid system with functional cannabinoid receptors, providing biological plausibility for topical CBD effects. Research is early but the dermatological applications are expanding.
Questions still open
- Which specific skin conditions respond best to topical CBD? What concentrations and formulations are needed for clinical efficacy?
Common questions
Does topical CBD work for skin conditions?
Could CBD replace topical steroids?
Read the original research
Topical cannabidiol (CBD) in skin pathology - A comprehensive review and prospects for new therapeutic opportunities.
South African family practice : official journal of the South African Academy of Family Practice/Primary Care, 64(1), e1-e4
Citation
Makhakhe, Lehlohonolo. (2022). Topical cannabidiol (CBD) in skin pathology - A comprehensive review and prospects for new therapeutic opportunities.. South African family practice : official journal of the South African Academy of Family Practice/Primary Care, 64(1), e1-e4. https://doi.org/10.4102/safp.v64i1.5493
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