After Getting Medical Cannabis Certification, 41% of Pain Patients Never Actually Used It

Among 225 chronic pain patients on opioids who were newly certified for medical cannabis, 41% did not use any cannabis products in the first three months, with White race, multi-site pain, and sedative use predicting uptake.

Zhang, Chenshu et al.·Cannabis and cannabinoid research·2024·Moderate EvidenceLongitudinal Cohort
RTHC-05850Longitudinal CohortModerate Evidence2024RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Longitudinal Cohort
Evidence
Moderate Evidence
Sample
N=225

What This Study Found

Within three months of certification, 29% used predominantly high-THC products, 30% used other products, and 41% did not use any cannabis. White race, multi-site pain, and sedative use predicted MC use. Current tobacco and unregulated cannabis use predicted non-use. Among those who used MC, female gender and older age predicted lower likelihood of choosing high-THC products.

Key Numbers

225 patients enrolled. 29% used high-THC products, 30% used other products, 41% did not use MC. Non-Hispanic White race, multi-site pain, and past 30-day sedative use predicted MC use. Female gender and older age predicted lower high-THC product choice.

How They Did This

Longitudinal cohort study of 225 adults with chronic/severe pain on opioids who were newly certified for medical cannabis in New York State (November 2018-January 2022). Web-based assessments every 2 weeks for 3 months. Generalized estimating equation models examined predictors.

Why This Research Matters

Getting certified does not mean patients will use medical cannabis. Understanding who actually follows through -- and what products they choose -- reveals barriers to access and potential disparities that certification alone does not solve.

The Bigger Picture

The finding that unregulated cannabis users were less likely to use medical cannabis after certification suggests these patients may already be accessing cannabis outside the medical system and see the legal program as redundant or inferior. This has implications for states trying to transition illicit users into regulated systems.

What This Study Doesn't Tell Us

New York's medical cannabis program during the study period was restrictive compared to other states, potentially limiting product options and access. The 3-month follow-up may not capture longer-term adoption patterns. The sample may not represent all MC-certified patients.

Questions This Raises

  • ?Would reducing cost barriers increase MC adoption among certified patients?
  • ?Do patients who never use MC after certification return to or increase their opioid use?

Trust & Context

Key Stat:
41% of certified patients did not use medical cannabis within 3 months
Evidence Grade:
Moderate: prospective longitudinal design with biweekly assessment, but single-state program with restrictive policies may limit generalizability.
Study Age:
2024 study using 2018-2022 data.
Original Title:
Factors Associated with Medical Cannabis Use After Certification: A Three-Month Longitudinal Study.
Published In:
Cannabis and cannabinoid research, 9(3), e859-e869 (2024)
Database ID:
RTHC-05850

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-ControlFollows or compares groups over time
This study
Cross-Sectional / Observational
Case Report / Animal Study

Follows a group of people over time to track how outcomes develop.

What do these levels mean? →

Frequently Asked Questions

Why did certified patients not use medical cannabis?

The study identified that existing tobacco and unregulated cannabis use predicted non-use, suggesting some patients already had access through other channels. Cost, product availability, and the restrictive nature of New York's program may also have been barriers.

Who chose high-THC products?

Male and younger patients were more likely to choose high-THC products. Female patients and older adults tended toward non-THC-dominant formulations, possibly reflecting different pain management priorities or concerns about psychoactive effects.

Read More on RethinkTHC

Cite This Study

RTHC-05850·https://rethinkthc.com/research/RTHC-05850

APA

Zhang, Chenshu; Slawek, Deepika E; Ross, Jonathan; Zolotov, Yuval; Castillo, Felipe; Levin, Frances R; Sohler, Nancy L; Minami, Haruka; Cunningham, Chinazo O; Starrels, Joanna L; Arnsten, Julia H. (2024). Factors Associated with Medical Cannabis Use After Certification: A Three-Month Longitudinal Study.. Cannabis and cannabinoid research, 9(3), e859-e869. https://doi.org/10.1089/can.2022.0248

MLA

Zhang, Chenshu, et al. "Factors Associated with Medical Cannabis Use After Certification: A Three-Month Longitudinal Study.." Cannabis and cannabinoid research, 2024. https://doi.org/10.1089/can.2022.0248

RethinkTHC

RethinkTHC Research Database. "Factors Associated with Medical Cannabis Use After Certifica..." RTHC-05850. Retrieved from https://rethinkthc.com/research/zhang-2024-factors-associated-with-medical

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.