CBD Did Not Block THC's Effect on Attentional Bias Toward Cannabis Cues
In a crossover trial with 46 users, THC increased attentional bias toward cannabis cues and CBD at three doses did not reduce this effect.
Quick Facts
What This Study Found
THC (10 mg) increased attentional bias (d=0.41, P=0.03). CBD at 10, 20, or 30 mg had no effect at any dose.
Key Numbers
46 participants; 4 sessions; THC 10 mg; CBD 0/10/20/30 mg; bias increase d=0.41; no CBD effect
How They Did This
Double-blind, randomized, within-subjects crossover with 46 infrequent users across four sessions.
Why This Research Matters
Challenges the notion that CBD cancels out THC's harmful properties for this addiction-relevant marker.
The Bigger Picture
At ratios found in commercial cannabis, CBD did not protect against this addiction-relevant THC effect.
What This Study Doesn't Tell Us
Infrequent users only. Proxy measure. Single acute exposure. One THC dose.
Questions This Raises
- ?Does CBD counteract other THC effects?
- ?Would higher CBD ratios help?
Trust & Context
- Key Stat:
- CBD had no effect on THC-induced attentional bias at any dose
- Evidence Grade:
- Well-designed crossover trial with multiple CBD doses.
- Study Age:
- Published in 2024.
- Original Title:
- Cannabidiol does not attenuate acute delta-9-tetrahydrocannabinol-induced attentional bias in healthy volunteers: A randomised, double-blind, cross-over study.
- Published In:
- Addiction (Abingdon, England), 119(2), 322-333 (2024)
- Authors:
- Oliver, Dominic(8), Englund, Amir(6), Chesney, Edward(13), Chester, Lucy, Wilson, Jack, Sovi, Simina, Wigroth, Stina, Hodsoll, John, Strang, John, Murray, Robin M, Freeman, Tom P, Fusar-Poli, Paolo, McGuire, Philip
- Database ID:
- RTHC-05600
Evidence Hierarchy
Participants are randomly assigned to treatment or placebo groups to test cause and effect.
What do these levels mean? →Frequently Asked Questions
Does CBD cancel THC's effects?
Not for attentional bias, an addiction-relevant marker.
What is attentional bias?
Automatically paying more attention to drug-related cues, a marker of addiction vulnerability.
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Cite This Study
https://rethinkthc.com/research/RTHC-05600APA
Oliver, Dominic; Englund, Amir; Chesney, Edward; Chester, Lucy; Wilson, Jack; Sovi, Simina; Wigroth, Stina; Hodsoll, John; Strang, John; Murray, Robin M; Freeman, Tom P; Fusar-Poli, Paolo; McGuire, Philip. (2024). Cannabidiol does not attenuate acute delta-9-tetrahydrocannabinol-induced attentional bias in healthy volunteers: A randomised, double-blind, cross-over study.. Addiction (Abingdon, England), 119(2), 322-333. https://doi.org/10.1111/add.16353
MLA
Oliver, Dominic, et al. "Cannabidiol does not attenuate acute delta-9-tetrahydrocannabinol-induced attentional bias in healthy volunteers: A randomised, double-blind, cross-over study.." Addiction (Abingdon, 2024. https://doi.org/10.1111/add.16353
RethinkTHC
RethinkTHC Research Database. "Cannabidiol does not attenuate acute delta-9-tetrahydrocanna..." RTHC-05600. Retrieved from https://rethinkthc.com/research/oliver-2024-cannabidiol-does-not-attenuate
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.