CBD/THC Extract Did Not Improve Pain Outcomes After Knee Surgery in Dogs

There were no significant differences in pain scores, range of motion, thigh circumference, or gait symmetry between dogs receiving CBD:THC extract and those receiving placebo, when both groups also received standard analgesics. Minor benefits from the higher dose appeared only on day 1 and did not persist. No serious adverse events occurred.

Randomized, double-blinded, placebo-controlled trial of 48 dogs (42 completers) undergoing TPLO knee surgery. Three groups: placebo, low CBD (2 mg/kg), and high CBD (5 mg/kg) with a 20:1 CBD:THC ratio. All dogs received standard analgesics. Assessments at days 1 and 14 post-surgery. Published in Frontiers in Veterinary Science.

Pet owners increasingly give CBD products to dogs for pain, often based on anecdotal reports. This controlled trial found that when added to standard pain management, CBD did not provide additional benefit for post-surgical pain.

This adds to evidence that CBD may not provide additional pain relief beyond standard analgesics. The negative result is important because it helps prevent unnecessary supplementation and directs attention toward proven pain management strategies.

Small sample size per group. Only one CBD:THC ratio tested. Standard analgesic protocol was comprehensive, possibly leaving little room for additional improvement. 14-day follow-up only. Variable plasma cannabinoid levels suggest inconsistent absorption.