Do People With Nerve Pain Use Cannabis Differently Than Those With Other Pain?

Pain clinic patients with neuropathic pain used THC/CBD products more frequently than those with other types of pain—suggesting nerve pain may drive more intensive cannabis self-medication.

Laroya, Carl Joshua P et al.·Frontiers in pain research (Lausanne·2025·Preliminary EvidenceCross-Sectional·1 min read
RTHC-06899Cross SectionalPreliminary Evidence2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Cross-Sectional
Evidence
Preliminary Evidence
Sample
N=104
Participants
N=104 adults aged 18-65, 61.5% female, receiving care at a pain clinic

What This Study Found

This study surveyed 104 adults at a pain clinic, comparing cannabis use patterns between those whose most bothersome pain was neuropathic (nerve-related, 36.5%) versus non-neuropathic (63.5%).

Patients with neuropathic pain reported significantly more days per month of THC/CBD product use compared to those with non-neuropathic pain. This wasn't random—it suggests that people with nerve pain, which is notoriously difficult to treat with standard medications, may be turning to cannabis more intensively because conventional options aren't working well enough.

Neuropathic pain includes conditions like diabetic neuropathy, post-surgical nerve damage, and sciatica. These conditions respond poorly to standard painkillers (including opioids) and are one of the areas where cannabis has shown the most promising anecdotal and clinical evidence.

The study used the ID-Pain tool to classify pain types, which provides a standardized way to distinguish neuropathic from non-neuropathic pain based on symptom characteristics rather than physician diagnosis alone.

Key Numbers

N = 104 (61.5% female). 36.5% neuropathic pain, 63.5% non-neuropathic. Neuropathic pain patients used THC/CBD products significantly more days per month.

How They Did This

Cross-sectional survey of 104 adults (61.5% female) receiving care at a pain clinic. Pain categorized as neuropathic or non-neuropathic using ID-Pain scores. Cannabis product use assessed by frequency and duration. Linear regression models adjusted for age and sex.

Why This Research Matters

If neuropathic pain specifically drives more intensive cannabis use, that has implications for both medical cannabis programs and pain clinic practice. It suggests cannabis may be filling a gap where conventional pain treatments fall short—and that research on cannabis for nerve pain specifically should be prioritized over general chronic pain research.

The Bigger Picture

This pattern-of-use data complements clinical trial evidence. RTHC-00158 showed that THC:CBD improved pain scores specifically in cancer patients (even without improving overall symptoms), and RTHC-00161 found that medical marijuana access reduced strong opioid prescriptions after cancer surgery. Together, these studies suggest cannabis may have a particular niche in pain management—not as a general analgesic, but as a targeted option for pain types that respond poorly to other treatments.

What This Study Doesn't Tell Us

Small sample from a single pain clinic. Cross-sectional design can't determine causation—people with neuropathic pain may use more cannabis because it works, because they're more desperate, or for other reasons. Self-reported cannabis use. The ID-Pain tool classifies pain type based on symptoms rather than confirmed diagnoses. No data on whether the cannabis actually helped with pain.

Questions This Raises

  • ?Does more frequent cannabis use in neuropathic pain patients reflect genuine efficacy, or simply a more desperate search for relief?
  • ?Would randomized trials of cannabis specifically in neuropathic pain show benefits that general chronic pain trials haven't?
  • ?How do pain physicians view their patients' cannabis use?

Trust & Context

Key Stat:
Evidence Grade:
Small cross-sectional survey from a single clinic—hypothesis-generating but not able to establish whether cannabis is effective for nerve pain.
Study Age:
Published in 2025 with data from a U.S. pain clinic.
Original Title:
Cross-sectional comparison of cannabis use in adults with neuropathic versus non-neuropathic pain.
Published In:
Frontiers in pain research (Lausanne, Switzerland), 6, 1677391 (2025)Frontiers in Pain Research is a peer-reviewed journal focusing on pain management and treatment.
Database ID:
RTHC-06899

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study

A snapshot of a population at one point in time.

What do these levels mean? →

Read More on RethinkTHC

Cite This Study

RTHC-06899·https://rethinkthc.com/research/RTHC-06899

APA

Laroya, Carl Joshua P; Smith, Crystal Lederhos; Bindler, Ross J; McDonell, Michael G; Lewis, Jamie; Wilson, Marian. (2025). Cross-sectional comparison of cannabis use in adults with neuropathic versus non-neuropathic pain.. Frontiers in pain research (Lausanne, Switzerland), 6, 1677391. https://doi.org/10.3389/fpain.2025.1677391

MLA

Laroya, Carl Joshua P, et al. "Cross-sectional comparison of cannabis use in adults with neuropathic versus non-neuropathic pain.." Frontiers in pain research (Lausanne, 2025. https://doi.org/10.3389/fpain.2025.1677391

RethinkTHC

RethinkTHC Research Database. "Cross-sectional comparison of cannabis use in adults with ne..." RTHC-06899. Retrieved from https://rethinkthc.com/research/laroya-2025-crosssectional-comparison-of-cannabis

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.