CBD reduced movement disorder side effects and blood sugar spikes from the antipsychotic risperidone in rats
In rats given high-dose risperidone, CBD significantly reduced drug-induced blood sugar elevation and movement abnormalities without impairing cognition or locomotion.
Quick Facts
What This Study Found
CBD (5 mg/kg) significantly reduced risperidone-induced elevated fasting blood sugar when given after risperidone. CBD also reduced vacuous chewing movements (a model of tardive dyskinesia) when given before risperidone, and attenuated risperidone-induced increased muscle tone. Concomitant or sequential CBD and risperidone administration did not adversely affect cognition or locomotion.
Key Numbers
Risperidone: 10 mg/kg for 28 days. CBD: 5 mg/kg. CBD reduced elevated fasting blood sugar. CBD reduced VCM when given before risperidone. Both CBD and risperidone increased antioxidant enzyme activity and decreased pro-oxidant enzymes.
How They Did This
Six experimental groups of rats received oral risperidone (10 mg/kg) for 28 days, oral CBD (5 mg/kg) in various temporal relationships to risperidone, or CBD alone for 21 days. Vacuous chewing movements, muscle tone, fasting blood sugar, oxidative stress markers, cognition, and locomotion were assessed.
Why This Research Matters
Antipsychotic side effects (metabolic syndrome, movement disorders) are a major reason patients stop taking their medications. If CBD can mitigate these without adding cognitive problems, it could improve treatment adherence.
The Bigger Picture
This adds to a growing body of evidence that CBD may complement psychiatric medications by reducing their side effects. If confirmed in humans, CBD could become an adjunct treatment for people on antipsychotics.
What This Study Doesn't Tell Us
Animal study with high risperidone doses. Rats metabolize drugs differently than humans. Short duration relative to chronic antipsychotic use in humans. Small sample sizes per group. Effect sizes not reported.
Questions This Raises
- ?Would these protective effects hold at clinically relevant risperidone doses in humans?
- ?Could CBD affect risperidone's therapeutic efficacy while reducing side effects?
Trust & Context
- Key Stat:
- CBD reduced blood sugar spikes and movement side effects from risperidone
- Evidence Grade:
- Animal study with multiple outcome measures and temporal administration patterns, but limited by high drug doses and uncertain human relevance.
- Study Age:
- Published in 2022.
- Original Title:
- Effects of cannabidiol on vacuous chewing movements, plasma glucose and oxidative stress indices in rats administered high dose risperidone.
- Published In:
- Scientific reports, 12(1), 19718 (2022)
- Authors:
- Kajero, Jaiyeola Abiola, Seedat, Soraya, Ohaeri, Jude, Akindele, Abidemi, Aina, Oluwagbemiga
- Database ID:
- RTHC-03943
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
Can CBD reduce antipsychotic side effects?
In this rat study, CBD reduced risperidone-induced blood sugar elevation, involuntary movements, and muscle stiffness without causing cognitive or locomotor problems.
Is it safe to take CBD with antipsychotics?
In rats, combining CBD with risperidone did not produce adverse effects on cognition or movement. However, human studies are needed to confirm safety and rule out drug interactions.
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Cite This Study
https://rethinkthc.com/research/RTHC-03943APA
Kajero, Jaiyeola Abiola; Seedat, Soraya; Ohaeri, Jude; Akindele, Abidemi; Aina, Oluwagbemiga. (2022). Effects of cannabidiol on vacuous chewing movements, plasma glucose and oxidative stress indices in rats administered high dose risperidone.. Scientific reports, 12(1), 19718. https://doi.org/10.1038/s41598-022-24235-0
MLA
Kajero, Jaiyeola Abiola, et al. "Effects of cannabidiol on vacuous chewing movements, plasma glucose and oxidative stress indices in rats administered high dose risperidone.." Scientific reports, 2022. https://doi.org/10.1038/s41598-022-24235-0
RethinkTHC
RethinkTHC Research Database. "Effects of cannabidiol on vacuous chewing movements, plasma ..." RTHC-03943. Retrieved from https://rethinkthc.com/research/kajero-2022-effects-of-cannabidiol-on
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.