Two-Thirds of Women with Chronic Pelvic Pain and Fibromyalgia Have Tried CBD, with 81% Reporting Pain Improvement

Among 1,382 women with chronic pelvic pain and fibromyalgia, two-thirds had tried CBD, with 81% of current users reporting pain improvement and many substituting CBD for other medications.

RTHC-07796Cross Sectionallow2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Cross-Sectional
Evidence
low
Sample
N=1,382

What This Study Found

36.3% never used CBD, 29.2% past users, 34.5% current users. Among current users, 80.9% reported pain improvement. Those with pain improvement also reported better sleep, anxiety, depression, fatigue, and overall health. Many substituted CBD for at least one other medication. About half reported side effects, most minor (drowsiness 29% most common).

Key Numbers

1,382 participants. 34.5% current CBD users, 29.2% past users, 36.3% never used. Pain improvement: 80.9% of current users. Improved sleep, anxiety, depression, fatigue, overall health correlated with pain improvement. Side effects: ~50%, mostly minor (drowsiness 29%).

How They Did This

Cross-sectional secondary analysis of online survey distributed through the National Fibromyalgia Association (April-May 2020). Limited to participants with concurrent chronic pelvic pain diagnoses. 1,382 included participants.

Why This Research Matters

Chronic pelvic pain and fibromyalgia are notoriously difficult to treat. The high CBD use rate and self-reported symptom improvement, along with medication substitution, suggest patients are finding relief that conventional treatments may not provide — though placebo effects cannot be ruled out.

The Bigger Picture

The medication substitution finding is significant — if CBD allows patients to reduce use of opioids or other high-risk medications, it could represent meaningful harm reduction, even if its mechanisms are not fully understood.

What This Study Doesn't Tell Us

Self-reported outcomes susceptible to placebo and expectancy effects. Survey distributed through patient advocacy organization (selection bias). No control group. Cross-sectional design cannot establish causation. 2020 survey may not reflect current landscape.

Questions This Raises

  • ?What medications are patients substituting CBD for?
  • ?Would a controlled trial confirm the self-reported pain improvement?

Trust & Context

Key Stat:
Evidence Grade:
Large survey with good detail on use patterns, but self-reported outcomes, advocacy organization recruitment, and no control group limit evidence quality.
Study Age:
2025 publication with 2020 survey data.
Original Title:
Cannabidiol Use and Perceptions of Effectiveness in Women With Chronic Pelvic Pain.
Published In:
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 47(7), 102839 (2025)
Database ID:
RTHC-07796

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study

A snapshot of a population at one point in time.

What do these levels mean? →

Frequently Asked Questions

Does CBD help with chronic pelvic pain?

In this survey of 1,382 women with chronic pelvic pain and fibromyalgia, 81% of current CBD users reported pain improvement. Those who improved also reported better sleep, mood, and energy. However, this is self-reported and not from a controlled trial.

Can CBD replace other pain medications?

Many participants reported substituting CBD for at least one other medication. While promising for harm reduction, this survey cannot determine if CBD is as effective as the medications it replaced. Patients should consult their doctors before making substitutions.

Read More on RethinkTHC

Cite This Study

RTHC-07796·https://rethinkthc.com/research/RTHC-07796

APA

Till, Sara R; Whitmore, Gabrielle; As-Sanie, Sawsan; Matallana, Lynne; Boehnke, Kevin F. (2025). Cannabidiol Use and Perceptions of Effectiveness in Women With Chronic Pelvic Pain.. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 47(7), 102839. https://doi.org/10.1016/j.jogc.2025.102839

MLA

Till, Sara R, et al. "Cannabidiol Use and Perceptions of Effectiveness in Women With Chronic Pelvic Pain.." Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2025. https://doi.org/10.1016/j.jogc.2025.102839

RethinkTHC

RethinkTHC Research Database. "Cannabidiol Use and Perceptions of Effectiveness in Women Wi..." RTHC-07796. Retrieved from https://rethinkthc.com/research/till-2025-cannabidiol-use-and-perceptions

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.