How CBD Might Protect the Gut: Antioxidant and Anti-Inflammatory Pathways ↗
Review mapped CBD's gut-protective mechanisms: antioxidant pathway activation, anti-inflammatory signaling, barrier integrity preservation, and microbiota modulation.
Research library — page 128
Browse more cannabis research, findings, methods, and limitations.
Tracking Why People Use Cannabis Day by Day Could Power Personalized Interventions ↗
Pilot study tracking daily cannabis use motives over 28 days finds shifts toward sleep-aid and availability motives predict higher use, demonstrating feasibility of adaptive just-in-time interventions.
Cannabis Use Disorder Linked to Lower Pancreatic Cancer Detection in Pancreatitis Patients ↗
Large database study finds chronic pancreatitis patients with cannabis use disorder had 74% fewer pancreatic cancer detections but slightly more acute flare-ups, warranting further investigation.
THC Kills Pain by Blocking Nerve Signals — Without Involving Cannabis Receptors ↗
THC directly blocks pain-signaling sodium channels NaV1.7 and NaV1.8 through the local anesthetic binding site, revealing a cannabinoid-receptor-independent mechanism for pain relief.
CBD Reduces Both Pain and Anxiety in Rats — But Anxiety-Prone Animals Respond Differently ↗
Chronic CBD reduced nerve pain in all rat anxiety lineages but had differential anxiety effects, with anxiety-prone animals responding less — suggesting individual anxiety traits may affect CBD treatment outcomes.
Cannabis Users' Brains React More to Cannabis Cues But Less to Money — and That May Predict Quitting ↗
EEG study finds current cannabis users show heightened brain responses to cannabis cues and blunted monetary reward responses, but paradoxically, stronger cue reactions predicted reduced use at 3 months.
Alcohol and Cannabis Connect to Different Mental Health Symptoms — and the Pattern Doesn't Change with Age ↗
Network analysis reveals alcohol problems link uniquely to anxiety and suicidal thoughts while cannabis problems link to mania and dissociation, with patterns stable across ages 16-81.
Reddit Reveals 1,177 Cannabis Adverse Experiences That Needed Medical Attention ↗
AI analysis of Reddit identified 1,177 self-reported cannabis adverse experiences requiring medical attention, demonstrating social media's potential for cannabis product safety surveillance.
Brain Stimulation Shows Early Promise for Treating Cannabis Use Disorder ↗
First pilot trial of H4 deep brain stimulation for cannabis use disorder found the treatment feasible and tolerable — laying groundwork for controlled efficacy trials.
A New Way to Measure How Different State Cannabis Laws Actually Are ↗
New measurement approach captures 36 state cannabis policy characteristics across three bundles (pharmaceutical, permissive, fiscal), enabling research on how specific policy features affect health outcomes.
Fruit Flies Validate a New Model for Studying Chronic Pain — and CBD Works in It ↗
Genetically modified fruit fly with chronic pain-related sodium channel mutation responds to CBD but not conventional treatment, validating a fast, ethical model for screening new pain medications.
Lennox-Gastaut Syndrome Diagnoses Spiked After FDA Approved CBD — Then Returned to Normal ↗
LGS diagnoses in the US jumped ~60% after the 2018 FDA approval of CBD for the condition, then returned to baseline, suggesting treatment availability may have influenced diagnostic practices.
Cannabis Use Creates Opposite Brain Inflammation Patterns in People With and Without Psychosis ↗
Brain imaging shows cannabis use has opposite inflammation effects in healthy people (lower) versus psychosis patients (higher), and may block antipsychotic medication's brain effects in psychosis.
The Mitochondrial CB1 Receptor: Where Cannabis Science Meets Brain Energy and Disease ↗
Review explores how the recently discovered mitochondrial CB1 receptor regulates brain energy, memory, and neuronal survival, with potential implications for treating neurodegenerative diseases.
Mice Without CB1 Receptors Are Protected from Inflammation-Induced Preterm Birth ↗
CB1 receptor knockout mice show significantly lower preterm birth rates under inflammatory conditions, with reduced prostaglandins and inflammatory markers in uterine tissue.
Cannabis Use Is Rising Among High-Risk Youth in Care — Especially Girls and Older Teens ↗
Ten-year analysis of 2,256 youth entering residential care shows hazardous cannabis use increasing — especially among girls and older teens — diverging from declining trends in the general youth population.
Cannabis Research Has a Sex Problem — And Here's How to Fix It ↗
Commentary reveals cannabis cognitive research is male-centered and underpowered for sex analysis, with only 6 of 29 studies finding sex differences — likely reflecting methods, not biology.
Screening for Cannabis Use in Primary Care Catches More Cases — But Getting People Into Treatment Remains Hard ↗
Cluster-randomized trial shows systematic cannabis screening in 19 primary care sites increased detection 17-fold and doubled treatment initiation for CUD, but treatment engagement remained unchanged.
Only 19% of Older Cannabis Users Discussed Their Use With a Clinician ↗
Only 19% of older cannabis users discussed use with clinicians; Hispanic/Latine adults least likely to be screened.
How Long Cannabis Shows Up in Urine — and Why Current Thresholds May Be Wrong ↗
Systematic review of 92 studies found even low THC doses can trigger positive urine tests, and regular users may test positive for weeks — exposing problems with current thresholds.
Cannabis Advertising Was Associated With 77% Higher Odds of Cannabis Use ↗
Meta-analysis: cannabis advertising linked to 77% higher odds of use; social media ads showed strongest effect (3.38x).
College Students Misusing Stimulants Were More Likely to Also Use Cannabis ↗
College students misusing stimulants had significantly higher cannabis use, especially nonmedical misusers.
The Link Between Teen Cannabis Use and Psychological Distress Strengthened From 2013 to 2023 ↗
Over a decade, the teen cannabis-distress link grew stronger, especially for frequent female users, while overall teen use declined.
Cannabis Used by Up to 95% of Endometriosis Patients for Pain, But No Controlled Trials Exist ↗
Up to 95% of endometriosis patients use cannabis for pain, but no controlled trials exist to confirm efficacy.
CBD Showed Promising but Inconclusive Heart Recovery Benefits in Acute Myocarditis Trial ↗
Phase 2 RCT: CBD missed primary cardiac endpoints but significantly reduced LV mass and showed anti-inflammatory trends in myocarditis.
Among people with HIV, those who used cannabis for medical or emotional reasons also used more other substances ↗
Among people with HIV, cannabis users motivated by medical or emotional reasons had higher polysubstance use than recreational users.
Varenicline reduced cannabis use in men with cannabis use disorder but not in women ↗
A 12-week RCT found varenicline reduced cannabis use in men with CUD but had no effect in women.
Canadian survey finds cancer survivors prioritize symptom relief and daily functioning when considering medical cannabis ↗
Survey of 1,089 Canadians found symptom relief and daily functioning matter most when considering medical cannabis for cancer.
A virtual group therapy program significantly reduced cannabis use, cravings, depression, and anxiety in adults with cannabis use disorder ↗
A 12-week virtual group therapy program reduced cannabis use, cravings, depression, and anxiety with 68% retention.
A text-based mobile health treatment for young adults with cannabis use disorder worked equally well in rural and urban areas ↗
A text-based mobile treatment for young adults with CUD reduced cannabis use at 6 months with equal effectiveness in rural and urban areas.
Bisexual women had the highest rates of polysubstance use combinations involving cannabis and binge drinking ↗
National survey finds bisexual women had the highest rates of polysubstance combinations involving cannabis and binge drinking.
Cannabis with THC impairs driving for about 4-5 hours after inhalation, and adding alcohol makes it worse ↗
Review confirms THC impairs driving for 4-5 hours, CBD does not impair driving, and alcohol plus cannabis amplifies the effect.
Smoking cannabis reduced alcohol consumption by up to 27% in a controlled trial of heavy drinkers ↗
A controlled crossover trial found cannabis reduced alcohol consumption by 19-27% in heavy drinkers who also use cannabis.
College students across seven countries fell into three substance use classes, with polysubstance users showing higher impulsivity and childhood adversity ↗
Study of 9,065 college students in seven countries finds polysubstance users had more childhood adversity, impulsivity, and ruminative thinking.
People were willing to buy and use more cannabis when they had more time before they needed to drive ↗
Behavioral economics study finds cannabis demand decreases as driving becomes more imminent, and risk perception influences consumption levels.
Trauma patients who tested positive for THC were 66% more likely to screen positive for post-traumatic stress symptoms ↗
Trauma patients who tested positive for THC on admission were 66% more likely to screen positive for post-traumatic stress symptoms.
Recreational drug use, including cannabis, nearly tripled the risk of major cardiovascular events within one year of cardiac hospitalization ↗
Prospective French study finds recreational drug use, including cannabis, nearly tripled the risk of major cardiac events at one year post-hospitalization.
Despite increasing cannabis potency in Europe, the severity of emergency department visits for cannabis toxicity stayed the same over 10 years ↗
Ten-year European data from 40 EDs shows cannabis toxicity severity stayed stable despite increasing potency.
Integrated therapy plus AI-enhanced contingency management shows promise for treating cannabis use disorder with co-occurring mental health conditions ↗
Systematic review of 38 studies finds integrated CBT works for CUD with co-occurring conditions, and AI tools can enhance contingency management.
Endocannabinoid-metabolizing enzymes in tumors helped colon cancer evade the immune system in mice ↗
Mouse study reveals endocannabinoid-metabolizing enzymes help colon tumors evade the immune system; blocking the pathway improved immunotherapy.
A non-psychoactive hemp seed extract slowed colorectal cancer cell growth by triggering metabolic stress ↗
Non-psychoactive hemp seed extract slowed colorectal cancer cell growth by triggering metabolic stress; adding an autophagy inhibitor boosted the effect by 30%.
Cannabis use disorder was linked to more postoperative pain and skin complications after tummy tuck surgery ↗
Matched analysis of 1,596 patients finds cannabis use disorder linked to 82% more postoperative pain and 48% more wound issues after panniculectomy.
Cannabis smoke caused more damage to placental cells than THC alone, suggesting combustion byproducts add their own risks ↗
Cannabis smoke extract caused placental cell damage beyond what THC alone produced, and blocking cannabinoid receptors did not prevent it.
Young adults reported better sleep quality on days they used alcohol and cannabis together compared to alcohol-only or no-use days ↗
Daily diary study finds young adults report better sleep quality on days they use alcohol and cannabis together versus alcohol-only or no-use days.
High doses of CBG impaired sustained attention in female rats but not males, despite marketing claims of cognitive enhancement ↗
High-dose CBG impaired sustained attention in female rats but not males, contradicting marketing claims of cognitive enhancement.
Nearly 60% of top hip-hop music videos on YouTube contained nicotine or cannabis depictions, generating over 100 billion substance impressions ↗
Analysis of 1,160 top YouTube videos finds hip-hop/rap 13x more likely to show nicotine or cannabis, generating over 100 billion substance impressions.
Older adults had lower baseline endocannabinoid levels but showed larger increases after cannabis use than younger adults ↗
Older adults had lower baseline endocannabinoid levels but showed larger increases after cannabis use than younger adults.
A potent synthetic cannabinoid caused loss of consciousness in 81% of emergency cases, with seizures in 30% and four deaths ↗
202 emergency presentations for synthetic cannabinoid MDMB-4en-PINACA: 81% unconscious, 30% seizures, 4 deaths, mostly homeless men.
Cannabinoids may influence oral diseases like cancer and gum disease through autophagy pathways, but clinical evidence is lacking ↗
Review finds cannabinoids modulate autophagy in oral tissues via mTOR/AMPK pathways, with potential for oral cancer and periodontal disease.
Large meta-analysis finds regular cannabis use raises both pro-inflammatory and anti-inflammatory markers, not just one or the other ↗
Meta-analysis of 46 studies finds cannabis use elevates both pro- and anti-inflammatory markers, suggesting immunomodulation rather than anti-inflammatory effects.