Combining methamphetamine and cannabis was linked to more severe asthma attacks requiring intubation ↗
Co-use of methamphetamine and cannabis linked to higher intubation rates and more severe asthma attacks among hospitalized patients.
Research library — page 129
Browse more cannabis research, findings, methods, and limitations.
Finding the Right Antipsychotic Dose After Cannabis-Induced Psychosis ↗
Swedish nationwide study found moderate antipsychotic doses most effective for preventing psychotic relapse after cannabis-induced psychosis — higher doses added no benefit.
Stronger alcohol and cannabis policies each independently reduced substance-involved motor vehicle deaths ↗
Decade of US crash data shows stronger alcohol and cannabis policies each independently reduce substance-involved motor vehicle deaths.
Medical cannabis improved sleep, fatigue, and pain for patients with muscle spasticity or spasms, but not physical functioning ↗
Medical cannabis improved sleep, fatigue, and pain for spasticity/spasm patients but not physical functioning.
How Cancer Patients Actually Navigate Medical Cannabis Products ↗
Qualitative study found cancer patients overwhelmed by dispensary product variety, using imprecise dosing and frequently switching between multiple administration routes.
Both cannabis and tobacco use were associated with higher suicide attempt rates among veterans prescribed opioids ↗
In 923,000+ veterans on opioids, cannabis linked to 11% more suicide attempts; tobacco to more attempts, deaths, and overdose deaths.
Ultra-low-dose THC given before Alzheimer symptoms appeared reduced brain inflammation in mice, with different brain regions affected by sex ↗
Monthly ultra-low-dose THC prevented cognitive decline in Alzheimer mice, with sex-specific anti-inflammatory patterns.
Daily CBD did not rescue behavior or brain volume in an aggressive Alzheimer mouse model, but did reduce microglial reactivity ↗
Daily CBD in Alzheimer mice reduced brain immune cell reactivity but did not improve cognition, behavior, or brain volume.
The Two Endocannabinoids Talk to Different Brain Cells ↗
Nature Neuroscience study reveals 2-AG and anandamide have completely separate cellular targets in the hippocampus, with 2-AG signaling to neurons and anandamide signaling to astrocytes.
When Average Cannabis Use Goes Up Among Teens, Heavy Use Goes Up Too ↗
Analysis of 260,000+ Swedish students over 33 years shows that rising average cannabis use among teens predictably drives increases in heavy use.
How Common Is Substance Use Among Pro Soccer Players in Ghana? ↗
Survey of 139 Ghanaian pro footballers found 44.6% used substances, with caffeine dominant and cannabis use under 3%.
New Mothers Who Used Cannabis in Pregnancy Share Why They Continue Postpartum ↗
Qualitative study finds most new mothers who used cannabis in pregnancy continued postpartum, citing mental health and pain, while wanting better information about breastfeeding risks.
How CBD Interacts With the Brain: Mapping Its Many Receptor Targets for Parkinson's ↗
Review maps CBD's extensive receptor interactions beyond the endocannabinoid system, highlighting both therapeutic potential and complexity for Parkinson's disease.
Melatonin May Protect Against Cannabis-Related Hormonal Disruption in Female Rats ↗
Animal study finds melatonin protects against cannabis-induced reproductive hormone disruption in female rats, with CB1 receptors primarily responsible for the hormonal effects.
Cannabis Use Linked to Higher Erectile Dysfunction Odds in Sexual Minority Men ↗
Survey of 549 sexual minority men found cannabis users had 83% higher odds of erectile dysfunction, highlighting an understudied intersection of cannabis and sexual health.
Racial Discrimination Linked to Cannabis Use Intentions in Preteens ↗
ABCD Study found racial discrimination in preteens linked to cannabis use intentions through a pathway of increased perceived accessibility and decreased perceived harm.
Cannabis Use Makes Quitting Tobacco Harder, But CBD Might Help ↗
Major meta-analysis shows cannabis co-use reduces tobacco quit odds by 35%, but CBD interventions cut cigarette consumption by 40%, suggesting a promising new cessation approach.
Cannabis Oil Matched Lorazepam for Treating Chronic Insomnia in Head-to-Head Trial ↗
RCT with 60 chronic insomnia patients found cannabis oil matched lorazepam for sleep improvement over 4 weeks, with better quality-of-life outcomes and only mild side effects.
Endocannabinoid System Found to Play a Role in Chemotherapy-Caused Hearing Loss ↗
Study reveals cisplatin chemotherapy disrupts the endocannabinoid system in hearing cells, and blocking CB2 receptors may protect against the damage.
CBD Prevented Colorectal Precancerous Growths by Suppressing Immune-Blocking Cells ↗
CBD prevented precancerous colorectal growths in two mouse models by targeting EEF1B2 to suppress immune-blocking cells, enabling stronger anti-tumor immune responses.
Cannabis Users Needed More Propofol During Dental Surgery Under General Anesthesia ↗
Prospective study of 49 dental surgery patients found heavy cannabis users needed significantly more propofol under IV general anesthesia, with a practical risk stratification system.
Long-Term Cannabis User Developed Rare Delusional Skin Infestation ↗
Case report of a daily cannabis user who developed delusional infestation -- believing parasites were under his skin -- highlighting an unusual presentation of cannabis-associated psychosis.
The Growing Risk of Cannabis Drug Interactions as Legal Access Expands ↗
Review mapped how cannabinoids interfere with drug metabolism through CYP450 enzymes, potentially altering effectiveness of antidepressants, blood thinners, opioids, and more.
Cannabinoids Show Antitumor Activity Against Skin Cancer in Lab Studies ↗
Review finds preclinical evidence supporting cannabinoid antitumor activity against skin cancers through multiple mechanisms, with topical CBD formulations as a promising delivery approach.
Cannabis Users With Schizophrenia Had Lower Rates of Metabolic Syndrome ↗
Analysis of 988 schizophrenia patients found THC-positive individuals had 36% lower odds of metabolic syndrome, with significantly less central obesity.
Could Ozempic-Type Drugs Help Treat Addiction? What Clinical Trials Are Testing ↗
Systematic review finds 33 clinical trials testing Ozempic-type drugs for addiction, mostly for alcohol and tobacco, with zero trials targeting cannabis use disorder.
Why Cannabis May Be Especially Dangerous for Older Drivers ↗
Review argues that older adults may be more impaired by cannabis while driving due to age-related changes in metabolism, cognition, and the endocannabinoid system.
Endocannabinoid System Genes Are Disrupted in Inflamed Bowel Disease Tissue ↗
Study of IBD patient biopsies found 6 of 10 endocannabinoid system genes dysregulated in inflamed tissue, with CB2 and GPR55 receptors upregulated.
Cannabis-Related ER Visits and Outpatient Encounters Rose 71% in Five Years ↗
FDA database study of 115 million insured adults found cannabis-related healthcare encounters rose 71% from 2017 to 2022, with no difference by state legalization status.
How Medical Cannabis Could Help Patients With Head and Neck Cancer ↗
Review explores how medical cannabis could address the severe symptom burden in head and neck cancer, including pain, nausea, cachexia, and difficulty swallowing.
Prenatal Tobacco Alone vs. With Cannabis Led to Different Behavioral Problems in Kids ↗
Longitudinal study of 293 families finds prenatal tobacco-cannabis co-exposure leads to childhood behavioral problems through emotion regulation difficulties, a different pathway than tobacco alone.
Prenatal Cannabis Plus Teenage Stress Increased Risk-Taking in Mice ↗
Mouse study shows prenatal cannabis exposure combined with adolescent stress increased risk-taking behavior, while neither factor alone had this effect.
How Alcohol Changes Your Endocannabinoid Levels and What That Means for How Drunk You Feel ↗
First study showing alcohol decreases 2-AG endocannabinoid levels, with the drop linked to less drug liking, suggesting the endocannabinoid system mediates alcohol reward.
Brain Regions That Shrink Most in Parkinson's Psychosis Are Rich in CB1 Cannabinoid Receptors ↗
Study links gray matter loss in Parkinson's psychosis to CB1 cannabinoid receptor brain distribution, suggesting the endocannabinoid system may play a role in these symptoms.
Smoking Synthetic Cannabinoids Creates Unknown Toxic Chemicals That Damage the Brain ↗
Systematic review reveals smoking synthetic cannabinoids creates unknown toxic chemicals with brain-damaging potential, with only 9 studies ever investigating these breakdown products.
Veterans in Addiction Treatment Describe Using Cannabis to Manage Pain ↗
Qualitative study found veterans in addiction treatment used cannabis to manage chronic pain, anxiety, and sleep — framing it as a harm reduction alternative to more dangerous substances.
Cannabis Users Were Less Likely to Go Opioid-Free After Colorectal Surgery ↗
Prospective study finds half of colorectal surgery patients can go opioid-free after discharge, but cannabis users were far less likely to achieve this.
Long-Term Cannabis Use Linked to Impaired Automatic Movement Learning ↗
Study found longer cannabis use history linked to weaker automatic movement learning and elevated resting brain activity, suggesting altered baseline neural dynamics.
Most Cancer Care Providers Think Cannabis Works but Feel Unprepared to Discuss It ↗
Survey finds 89% of cancer care providers believe cannabis manages symptoms but only 15% feel knowledgeable, revealing a critical education gap in oncology.
Can Cannabinoids Help With Pain in Older Adults? A Review of the Science ↗
Review explored how age-related endocannabinoid system changes and chronic inflammation ('inflammaging') create a rationale for cannabinoid pain therapy in older adults, though clinical evidence is limited.
Hemp's Potential for Brain Diseases: A Review of Seeds, Leaves, and Flowers ↗
Review found hemp-derived compounds from seeds, leaves, and flowers show neuroprotective potential across epilepsy, Alzheimer's, Parkinson's, and MS — mostly in preclinical studies.
Cannabis Users Reported More Pain After Breast Reconstruction Surgery ↗
Retrospective study of 237 breast reconstruction patients found cannabis users reported higher pain and used 52% more opioids, though this was not independent of other factors.
How Early Teens' Positive Expectations About Cannabis Develop Over Time ↗
ABCD Study found early adolescents follow distinct trajectories of cannabis expectancy development, with family monitoring and peer substance use as key factors.
Cannabis Use Patterns Differ by Sexual Identity, Attraction, and Gender ↗
National survey of 40,000+ adults reveals bisexual women have 2.57x higher odds of cannabis use, with distinct gender-specific patterns across sexual orientation dimensions.
Babies Exposed to Cannabis in the Womb Had Similar Health Outcomes at Age 2-3 ↗
Study of 4,270 Medicaid infants found no difference in healthcare use or developmental delay at age 3 between cannabis-exposed and unexposed babies.
Nearly 9 in 10 Malaysians Surveyed Support Medical Cannabis Based on Clinical Evidence ↗
Web survey of 2,047 Malaysians found 88.4% support medical cannabis based on clinical evidence, with education and low risk perception as strongest predictors.
Two Lesser-Known Cannabinoids Reduced Pain Through Multiple Receptor Pathways ↗
Study finds lesser-known cannabinoids CBV and THCV reduce pain through both vanilloid and cannabinoid receptor pathways in a genetic model organism.
College Students Who Feel They Don't Belong Use More Cannabis, But Mental Health Explains Why ↗
Survey of 327 college students finds lack of belonging drives cannabis use indirectly through depression and anxiety, suggesting mental health support may be key.
Female Mice Developed Greater THC Tolerance Than Males, Especially With HIV ↗
Mouse study shows females develop greater THC tolerance than males after 90 days, with chronic THC increasing anxiety in females and HIV status adding neuroinflammatory complexity.
Cannabis Terpenes Directly Activate Cannabinoid Receptors, Supporting the Entourage Effect ↗
Study shows 16 cannabis terpenes selectively activate CB1 and CB2 receptors at THC-comparable potency, providing molecular evidence for the entourage effect.