CBD oil improved autistic behaviors and reduced brain oxidative stress in a mouse model ↗
Mouse study found CBD oil improved autistic behaviors and reduced brain oxidative stress comparably to risperidone in a valproic acid-induced autism model.
Research library — page 93
Browse more cannabis research, findings, methods, and limitations.
Severe vomiting from cannabis hyperemesis caused a rare triple air leak in the chest and abdomen ↗
Case report of a 21-year-old with cannabis hyperemesis who developed a rare triple air leak in the chest and abdomen, mimicking esophageal rupture but resolving with conservative care.
Meta-analysis found cannabis use associated with 53% higher all-cause mortality, but evidence quality was low ↗
First meta-analysis on cannabis and mortality found 53% higher all-cause mortality risk across 17.5 million participants, but evidence quality was low with very high heterogeneity.
Marijuana and hashish use associated with over four times higher odds of severe periodontitis ↗
NHANES analysis of 3,690 adults found marijuana/hashish use associated with 4.3 times higher odds of severe periodontitis, a stronger association than any other substance tested.
Synthetic cannabinoid use linked to rhabdomyolysis requiring dialysis in a cancer patient ↗
Case report of a 48-year-old cancer patient who developed rhabdomyolysis requiring dialysis after synthetic cannabinoid use, highlighting a rare but serious toxicity.
Reddit posts revealed unreported drug interactions between cannabis products and immunosuppressants ↗
Reddit analysis of 63.5 million posts found users reporting previously undocumented drug interactions between consumer cannabis products and immunosuppressants.
Cannabis use shifted from recreational to medical purposes after spinal cord injury ↗
Survey of 80 Canadians with spinal cord injury found 42.5% used cannabis post-injury, shifting from recreational to pain and sleep motivations with edibles as preferred method.
Systematic review found cannabis-based medicines reduced neuropathic pain in most but not all RCTs ↗
Systematic review of 22 RCTs found cannabis-based medicines reduced neuropathic pain in 68% of trials, with better outcomes using personalized dosing strategies.
CBD and beta-caryophyllene together produced synergistic pain relief and antidepressant effects in mice ↗
Mouse study found combining CBD and beta-caryophyllene produced synergistic pain relief with antidepressant effects through reduced neuroinflammation.
How cannabis laws are designed matters more for youth mental health than whether they exist ↗
Analysis of YRBS data found cannabis legalization design matters for youth mental health: permissive and pharmaceutical bundles improved outcomes while fiscal focus worsened them.
Cannabis smoking did not cause detectable DNA damage in cheek cells, unlike tobacco and e-cigarettes ↗
Study of 100 participants found cannabis smoking produced no significant increase in oral DNA damage markers, unlike tobacco, reverse smoking, and e-cigarettes.
Spanish-language Twitter discourse heavily favored cannabis regulation while underemphasizing health risks ↗
Analysis of 35,527 Spanish-language tweets found 73% favored cannabis regulation while only 20% discussed health risks, revealing significant pro-legalization online bias.
CBD prevented morphine-induced pain hypersensitivity and partially reduced withdrawal in rats ↗
Rat study found CBD prevented morphine-induced pain hypersensitivity in both sexes and partially reduced withdrawal symptoms, with sex-dependent response patterns.
Synthetic cannabinoid AB-FUBINACA caused kidney damage through oxidative stress and cell death in mice ↗
Mouse study found synthetic cannabinoid AB-FUBINACA causes kidney damage through oxidative stress, inflammation, and mitochondrial dysfunction after just 5 days.
Cannabis smoking impaired sperm quality and DNA integrity more than tobacco smoking ↗
Study of 113 men found cannabis smokers had worse sperm motility and DNA integrity than both tobacco smokers and non-smokers.
National survey reveals how Americans use cannabis: smoking dominates but multimodal use is rising ↗
National survey of 119,000 adults found 14.7% used cannabis in the past month, with smoking dominant but multimodal use rising and strongly linked to tobacco patterns.
A 15-year-old developed extensive air leaks after vaping and cannabis use ↗
One of the youngest reported EVALI air leak cases: a 15-year-old developed pneumomediastinum and pneumorrhachis after vaping and cannabis use.
10 'Minor' Cannabinoids Tested for Pain Relief: THCP and CBC Were the Most Potent ↗
Systematic testing of 10 minor cannabinoids on pain neurons found THCP and CBC most potent at reducing pain signaling — expanding the analgesic toolkit beyond THC and CBD.
A single dose of THC disrupted brain network connectivity in young adult cannabis users ↗
Double-blind study of 33 occasional users found a single THC dose reduced resting-state brain connectivity across corticostriatal, sensory, and interoceptive networks.
Cannabigerol did not affect fear memory in mice but showed sex-dependent pain effects ↗
Mouse study found cannabigerol (CBG) had no effect on fear memory at any dose tested, though females showed an unusual biphasic pain response.
Recreational cannabis legalization caused increased traffic fatalities, primarily after retail sales began ↗
Rigorous causal analysis found recreational cannabis legalization increased traffic fatalities in US states, with the effect primarily linked to the start of retail sales.
Autopsy revealed organized coronary blood clot in a 34-year-old marijuana user with no atherosclerosis ↗
Autopsy of a 34-year-old marijuana user found fatal coronary occlusion from an organized blood clot with no atherosclerosis, suggesting cannabis-related thrombosis.
Family stress and sleep problems predicted marijuana use among Black adults with criminal justice contact ↗
Study of 1,476 Black adults with criminal justice contact found marijuana use linked to family stress and sleep problems in men, neighborhood stressors in women.
Prenatal cannabis and tobacco co-exposure produced worse offspring outcomes than either substance alone ↗
Systematic review of 46 studies found prenatal cannabis-tobacco co-exposure produced worse outcomes in physical development and emotional regulation than either substance alone.
Cannabis Vaping and Smoking Trigger the Same Inflammatory and Cancer Gene Pathways in Lung Cells ↗
Despite fewer toxicants in vapor, cannabis vaping triggered the same inflammatory, cancer, and stress gene pathways in lung cells as smoking — questioning the harm reduction narrative at the molecular level.
Young Iranian women used cannabis to cope with family dysfunction and relational trauma ↗
Qualitative study of 12 young Iranian women found family dysfunction and relational trauma drove cannabis use as a coping mechanism for unresolved emotional needs.
Nova Scotia alcohol sales dipped slightly after cannabis legalization but rose at stores selling both ↗
Nova Scotia alcohol sales fell 2.4% at alcohol-only stores but rose 3.1% at stores selling both cannabis and alcohol after legalization.
Canada's cannabis retail expansion changed use patterns more through falling prices than store count ↗
Analysis of 10 Canadian provinces found cannabis use changes were associated with falling prices, not rising store numbers, with increases among women and older adults.
Autism spectrum disorder features drove obsessive cannabis use and extreme food restriction in a young man ↗
Case of a 26-year-old with autism who developed obsessive cannabis use and severe food restriction, requiring integrated multidisciplinary inpatient treatment.
Cannabis use disorder increased post-surgical cardiovascular risk by 26% in a study of 289,000 patients ↗
Study of 289,000 surgical patients found cannabis use disorder increased post-surgical cardiovascular risk by 26%, with recreational use risky only for those with high baseline cardiac risk.
Sexual and gender minority youth had higher odds of future marijuana use but stress did not explain why ↗
ABCD Study found SGM youth had higher future marijuana use and past suicide attempts, but family conflict, discrimination, and trauma did not explain the disparity.
Depression, hopelessness, and suicide attempts before age 10 predicted marijuana initiation by age 15 ↗
ABCD Study found childhood depression, hopelessness, and suicide attempts before age 10 predicted marijuana initiation by age 15, independent of socioeconomic factors.
Early puberty and impulsivity partly explain why high family income protects less against marijuana use in Black youth ↗
ABCD Study found earlier puberty in high-income Black youth partly explains why family income is less protective against marijuana use for Black versus White adolescents.
High-CBD Extract Reduced Arthritis Severity in Two Mouse Models and Suppressed Human Immune Cell Inflammation ↗
High-CBD extract reduced inflammatory cytokines from human immune cells and lessened arthritis severity in two mouse models of RA — the most complete preclinical package yet for cannabinoids in rheumatoid arthritis.
Medical cannabis patients with severe anxiety showed no meaningful improvement over 12 months ↗
Longitudinal study of 526 medical cannabis patients found severe anxiety (21% of patients) did not improve over 12 months, while minimal and moderate anxiety showed slight but not clinically meaningful decreases.
Cannabis hyperemesis was mistaken for routine post-surgical nausea for three days ↗
Case of a 40-year-old daily cannabis user whose CHS was mistaken for routine post-surgical nausea for three days until hematemesis and hallucinations prompted the correct diagnosis.
Cannabis use linked to psychotic-like experiences in adolescent twins, driven by environment not genetics ↗
Twin study of 232 adolescents found cannabis use linked to psychotic-like experiences, driven by environmental rather than genetic factors, with no mediation by brain connectivity.
Younger women substituted THC for alcohol driven by sleep problems, while older women substituted less and were driven by PTSD ↗
Survey of 413 women found younger women substituted THC for alcohol driven by sleep problems (OR 5.82), while older women substituted less and were driven by PTSD symptoms.
High-dose CBD vaping triggered a manic episode in a man with no psychiatric history ↗
Case report of a 31-year-old with no psychiatric history who developed a manic episode after three months of escalating high-dose CBD vaping, resolving after discontinuation.
How Cannabis and Alcohol Show Up in Connecticut Crash Data ↗
Connecticut crash-toxicology data linkage found alcohol, cannabis, and other drugs significantly predicted driver injury, with lack of safety equipment as the strongest predictor.
THC-CBD Combination Did Not Help Alzheimer's Symptoms in Mice ↗
Three weeks of THC-CBD treatment did not improve Alzheimer's-related deficits in transgenic mice and produced genotype-dependent effects on anxiety.
Cannabis Use Disorder and Schizophrenia Share Genetic Roots — But the Relationship Goes Both Ways ↗
Genetic analysis of 200,000+ individuals found cannabis use disorder and schizophrenia share genetic roots — polygenic liability for each independently predicted the other condition.
Genetic Risk for Cannabis Use Disorder Independently Linked to Schizophrenia ↗
Genetic risk scores for cannabis use disorder predicted schizophrenia even in people without documented cannabis use, suggesting shared genetic pathways between the two conditions.
Prenatal Cannabis Use Linked to Two Rare Abdominal Wall Birth Defects ↗
Large cohort study of 363,952 births found prenatal cannabis use associated with a rare abdominal wall defect (omphalocele) but not with 36 other major birth defects.
Israel's Medical Cannabis Program Grew 4,400% in 13 Years ↗
Israel's medical cannabis program grew from 3,097 to over 140,000 licenses between 2011 and 2024, with a 7.5% decline after a 2024 HMO-led reform.
THC Had Mixed Cognitive Effects in Rats With HIV-Like Disease ↗
THC improved learning but worsened decision-making in HIV model rats, with effects specific to the disease model and not seen in healthy controls.
More Childhood Adversity Linked to More Frequent Cannabis Use in Teens ↗
Nationally representative survey of US high school students found higher adverse childhood experience scores significantly predicted more frequent cannabis use.
Brief Screening Tool Identified Risk Factors for Prenatal Cannabis Use ↗
Psychosocial screening at first prenatal visit found being unpartnered tripled the odds of prenatal cannabis use, supporting routine screening for targeted intervention.
Removing Cannabis From Drug Screening Criteria Improved Racial Equity in Maternity Care ↗
Removing cannabis as a urine drug screening indication in a maternity unit eliminated racial disparities in testing and CPS reporting without missing other substance use.
What Research Says About Prenatal Cannabis Exposure and Child Brain Development ↗
Review of prenatal cannabis exposure research found consistent links to higher ADHD risk in children, while effects on cognition, autism, and learning remained inconclusive.