Cannabis Use Disorder in Adolescents Linked to Later Mental Health Disorders: Cohort Study ↗
Cohort study finds adolescent cannabis use disorder associated with increased risk of developing subsequent mental health disorders.
Research library — page 77
Browse more cannabis research, findings, methods, and limitations.
Paper-Based Rapid Testing Devices for Forensic and Clinical Drug Detection ↗
Review examines paper-based microfluidic devices as rapid, portable drug detection tools for forensic and clinical toxicology.
Stakeholder Roles in Combating Substance Abuse in Rural South Africa ↗
Study examines how families, police, and social workers contribute to combating substance abuse in rural South Africa with limited resources.
Driving Under the Influence of Cannabis Held Steady From 2016-2020, Even as Cannabis Use Rose 29% ↗
National survey data from 2016-2020 found that cannabis-impaired driving among users actually decreased even as past-year cannabis use rose 29%, while alcohol-impaired driving also continued to decline.
Cannabis-Related ER Visits Carried the Highest Risk of Later Developing Schizophrenia in a Study of Nearly 10 Million People ↗
A study of nearly 10 million people found ER visits for substance-induced psychosis carried a 163-fold increased risk of later schizophrenia, with cannabis showing the highest transition risk of any substance.
Cannabis-Involved Traffic Injury ER Visits Rose 475% in Ontario Over a Decade, Accelerating After Commercialization ↗
Cannabis-involved traffic injury ER visits in Ontario rose 475% from 2010-2021, accelerating after retail expansion, though they remained rare at 0.04% of all traffic injury visits.
Cannabis Commercialization, Not Initial Legalization, Was Linked to a 30% Jump in ER Visits for Cannabis-Induced Psychosis ↗
Ontario data showed no increase in cannabis psychosis ER visits after initial legalization, but a 30% jump after retail and product expansion, driven by youth aged 19-24.
Acute Care for Cannabis Use During Pregnancy Nearly Doubled After Legalization in Ontario ↗
Cannabis-related acute care during pregnancy nearly doubled after legalization in Ontario, with associated increases in preterm birth and NICU admissions, though absolute numbers stayed small.
28% of Inpatients Using Medical Cannabis Met Criteria for Cannabis Use Disorder, Rising to 51% Among Dual-Use Patients ↗
Among 125 addiction treatment inpatients using medical cannabis, 28% of medical-only users and 51% of dual-use patients met criteria for cannabis use disorder, with very high psychiatric comorbidity.
Prescription CBD Without Clobazam Reduced Seizures in 30% of Lennox-Gastaut Patients at 12 Months ↗
Real-world European data showed plant-derived CBD without clobazam reduced seizures by 50%+ in 30% of LGS patients at 12 months, with 63% still taking it at one year.
Cannabis Exposure in the Womb Was Linked to Smaller Head Size Starting in the Second Trimester ↗
Cannabis-exposed pregnancies showed head circumference deficits starting in the second trimester, reaching more than 14 percentile points by birth, after controlling for other substance use.
A Young Woman With Diabetes Was Misdiagnosed With Gastroparesis for Two Years Before Cannabis Was Identified as the Cause ↗
A woman with type 1 diabetes had two years of monthly ER visits for vomiting misdiagnosed as gastroparesis, resolved completely when cannabinoid hyperemesis syndrome was identified and cannabis use stopped.
Long-Term Marijuana Use Was Linked to DNA Changes in Genes Related to Schizophrenia, Bipolar Disorder, and Cell Growth ↗
A longitudinal study of 1,000+ adults found marijuana use was associated with DNA methylation changes in genes related to schizophrenia, bipolar disorder, cell proliferation, and hormone signaling.
Medical Cannabis Did Not Significantly Improve Pain, Nausea, or Sleep Scores in Elderly Cancer Patients ↗
A chart review of elderly cancer patients found no significant improvement in pain, nausea, appetite, insomnia, or anxiety scores after starting medical cannabis.
CBD-Rich Cannabis Oil Reduced Seizures by 84% in Adults With Drug-Resistant Focal Epilepsy ↗
An open-label study found CBD-rich cannabis oil reduced seizures from 11 to 2.5 per month in adults with drug-resistant focal epilepsy, with 80% achieving 50%+ reduction.
Systematic Review Finds Cannabinoids Show Promise for IBD Symptoms but Optimal Dose and Delivery Remain Unknown ↗
Systematic review found most studies report cannabinoid benefits for IBD symptoms, but heterogeneous methods prevent determining optimal dose, formulation, or delivery.
Women Experiencing Partner Violence Were More Likely to Use Cannabis on Days With Higher PTSD Symptoms ↗
A 30-day experience sampling study of 145 women experiencing intimate partner violence found PTSD externalizing and arousal symptoms linked to same-period cannabis use but not future use.
National Survey Finds CBD Users Report Benefits but Also Moderate-to-Severe Side Effects Requiring Medical Attention ↗
A national survey of 1,158 Americans found CBD users perceived it as safe and helpful, but most reported adverse effects were moderate to severe, sometimes requiring medical attention.
Children Exposed to Both a Natural Disaster and Cannabis in the Womb Had a 31-Fold Increased Risk of Behavioral Disorders ↗
Children prenatally exposed to both a natural disaster and maternal cannabis use had synergistically elevated psychiatric risk, with a 31-fold increase in behavioral disorders.
Cannabis Clinic Websites Promote 20 Medical Uses but Cite Low-Quality Evidence and Rarely Mention Harms ↗
Ontario cannabis clinic websites promoted cannabis for 20 conditions using mostly low-quality evidence, and only 4 of 29 clinics mentioned any harms.
Medical Cannabis Side Effects Like Sedation and Dizziness Could Increase Workplace Injury Risk ↗
Review of 31 systematic reviews found medical cannabis commonly causes sedation, dizziness, and euphoria, all of which could reduce workplace safety.
Review Finds Strongest Clinical Evidence for Purified CBD in Anxiety, Psychosis, PTSD, and Substance Abuse ↗
A review of purified CBD clinical trials found the strongest evidence for anxiety (17 RCTs), psychosis (8 RCTs), PTSD (4 RCTs), and substance abuse (3 RCTs), but not for pain or sleep.
Drivers With Cannabis Markers in Urine Had 8x Higher Odds of Crash Involvement, Even Without Active THC in Blood ↗
Rome study found drivers with cannabis urinary markers had 8x higher crash odds even when blood THC was below 1 ng/mL.
Synthetic Cannabinoid WIN55,212-2 Caused Anxiety and Reduced Activity in Mice, With Female Mice Less Affected ↗
Synthetic cannabinoid WIN55,212-2 caused anxiety and reduced activity in mice dose-dependently, with female mice less affected.
Review Proposes a New Model of Adolescent Cannabis Use Disorder Based on Drug, Mindset, and Environment Interactions ↗
Narrative review proposes adolescent CUD develops through feedback loops between drug characteristics, individual mindset, and environmental setting.
Cannabis-Impaired Drivers Did Not Slow Down to Compensate for Their Impairment ↗
Study of 31 cannabis users found significant visual impairment after use but no compensatory speed reduction.
Preclinical Studies Support CBD for Cognitive Impairment, but Human Evidence Is Still Missing ↗
Review found strong preclinical evidence for CBD improving cognition, but human studies have not confirmed these effects.
Cannabis User With Hyperemesis Syndrome Suffered Repeated Severe Burns From Compulsive Hot Bathing ↗
A woman with CHS suffered repeated severe burns, sepsis, and ICU admissions from compulsive hot bathing.
Cannabis Use Was Linked to 2.5x Higher 30-Day Hospital Readmission for Ulcerative Colitis but Not Crohn's Disease ↗
Cannabis use linked to 2.5x higher 30-day readmission for UC but not Crohn's among 1,021 IBD patients.
Increasing Cannabis Use Made It Harder to Quit Cigarettes for People With HIV ↗
Among 374 PWH trying to quit smoking, increasing cannabis use was associated with 78% lower odds of cigarette abstinence.
Scoping Review Finds Preclinical Promise but Limited Clinical Evidence for Cannabis in Rheumatoid Arthritis ↗
Scoping review found preclinical support for cannabinoids in rheumatoid diseases but scarce and mixed clinical evidence.
Blocking an Endocannabinoid-Degrading Enzyme Protected Rat Brain Cells From Toxic Damage ↗
Blocking the enzyme that degrades the brain's main endocannabinoid protected rat brain tissue through multiple receptor pathways.
CB1 Cannabinoid Receptors Are Concentrated in Pain-Processing Spinal Cord Regions in Both Rats and Humans ↗
CB1 cannabinoid receptors are concentrated in spinal cord pain-processing regions in both rats and humans, consistent across sex.
Systematic Review of 9 RCTs Finds CBD for Neurodevelopmental Disorders Shows Potential but Inconsistent Results ↗
Only 9 RCTs exist for CBD across all neurodevelopmental disorders, with inconsistent results.
Cannabis Use Was Associated With Lower Odds of Complete Recovery From Cyclic Vomiting Syndrome ↗
15-year study of 455 CVS adults: only 19% fully recovered, with cannabis use predicting 64% lower resolution odds.
Chronic Cannabis User With Hyperemesis Syndrome Also Developed Recurrent Kidney Stones ↗
A daily cannabis user with CHS developed recurrent kidney stones, possibly from chronic dehydration.
Weekly Cannabis Use Was Linked to Greater Social Anxiety Severity and Suicide Risk in a National Sample ↗
National data showed weekly+ cannabis use was a stronger marker of social anxiety severity and suicide risk than formal cannabis use disorder diagnosis.
Prenatal Cannabis Exposure Disrupted Breathing Regulation in Offspring With Sex-Specific Effects Lasting Into Adolescence ↗
Prenatal cannabinoid exposure disrupted breathing regulation in rat offspring sex-specifically: males had altered CO2/O2 responses while females had increased apnea with reduced brainstem serotonin neurons.
Prenatal THC Exposure Altered Hippocampal Development in Mice Through a Specific Gene Pathway ↗
Prenatal THC altered mouse hippocampal development through the CB1 receptor and MEF2C pathway, with effects rescued by a CB1 blocker.
CBD Reprograms Immune Cells to Be More Anti-Inflammatory, but Only When They Are Activated ↗
CBD reprogrammed human dendritic cells during long-term treatment to mount anti-inflammatory responses when activated, with IL-10 signaling as the dominant pathway.
A Synthetic Cannabinoid 80x More Potent Than THC Was Found in Products Sold as Air Freshener in Italy ↗
A product sold as air freshener in Italy contained 8.5 mg of the potent synthetic cannabinoid 5F-Cumyl-PINACA, causing ER visits for hallucinations, tachycardia, and breathing difficulty.
CBD Did Not Interfere With Diazepam Nasal Spray for Seizure Emergencies in Epilepsy Patients ↗
Phase 3 analysis found CBD did not worsen safety or effectiveness of diazepam nasal spray for seizure clusters, with purified CBD patients showing the lowest drug-attributed adverse event rates.
Blocking the Brain's Endocannabinoid System Triggered a Full Stress Response in Rats, Even Without Any Stressor ↗
Multiple methods of blocking endocannabinoid signaling in rats all triggered full stress responses, proving this system actively suppresses stress at rest.
No Evidence-Based Intervention Effectively Reduces Cannabis Use in Young Adults With Psychosis, Review Finds ↗
Scoping review found no proven intervention for reducing cannabis use in young adults with psychosis, though MI, CBT, and family training show minimal evidence.
Prenatal Cannabinoid Exposure Caused Memory Deficits in Adolescent Rats by Disrupting a Key Neural Adhesion Molecule ↗
Prenatal cannabinoid exposure caused adolescent rat memory deficits through reduced PSA-NCAM and imbalanced glutamate signaling, with PSA administration rescuing the impairment.
How Cannabis Tolerance Builds: What Happens to Your Brain's CB1 Receptors ↗
Chronic cannabis use reduces CB1 receptor number and responsiveness throughout the brain — with significant sex differences — explaining why the same dose stops working over time.
CBD Improved Antioxidant Status in Rats Over 90 Days, While CBG Caused Liver Damage and Oxidative Stress ↗
90-day rat study found CBD improved antioxidant status safely, while CBG at similar doses caused liver damage, oxidative stress, and blood abnormalities.
Review Examines How Inhaled Cannabis Affects Lung Immune Defenses, With More Questions Than Answers ↗
Review found inhaled cannabis dampens lung immune function, potentially reducing inflammation but also impairing pathogen defense, with major knowledge gaps remaining.
No FDA-Approved Treatment Exists for Cannabis Craving, but 22 Trials Show Several Promising Approaches ↗
Review of 22 RCTs found no approved cannabis craving treatment, but THC+lofexidine, oxytocin, progesterone, and NAC show promise.
Prenatal Cannabis Use Disorder Was Linked to 86% Higher Odds of Infant Death in a Study of 2.4 Million Births ↗
Study of 2.38 million California births found prenatal cannabis use disorder linked to 45% higher preterm risk, 47% higher SGA risk, and 86% higher infant death odds.