Can Field Sobriety Tests Identify Cannabis-Impaired Drivers? A Randomized Trial ↗
Randomized trial finds standard field sobriety tests have limited effectiveness for detecting cannabis impairment, challenging current enforcement approaches.
Research library — page 76
Browse more cannabis research, findings, methods, and limitations.
How Recreational Cannabis Markets Affect Traffic Deaths, Suicides, and Opioid Overdoses ↗
Study examines how recreational cannabis markets affect traffic deaths, suicides, and opioid overdose fatalities across US states.
Lab Method for Testing Drug Activity at the CB2 Cannabinoid Receptor ↗
Detailed lab protocol for testing cannabinoid compound activity at the CB2 receptor using cyclic AMP assays, supporting drug discovery efforts.
How the Endocannabinoid and Kisspeptin Systems Interact to Control Male Reproduction ↗
Study reveals functional interaction between endocannabinoid and kisspeptin systems in male reproductive control, explaining potential fertility effects of cannabis.
Caregivers Report CBD Benefits Beyond Seizure Control for Dravet and Lennox-Gastaut ↗
Caregivers report CBD benefits beyond seizure control for Dravet and Lennox-Gastaut patients, including improved alertness, behavior, and quality of life.
Combining Prenatal Risk Factors with Adolescent Cannabis Exposure in Schizophrenia Models ↗
Dual-hit model shows prenatal risk factors combined with adolescent cannabis exposure produce more comprehensive schizophrenia-like symptoms than either alone.
Sex Differences in Endocannabinoid Levels During Cannabis Use Disorder and Abstinence ↗
Pilot study reveals sex differences in endocannabinoid tone during CUD and abstinence, supporting sex-specific treatment development.
Understanding Endocannabinoid Signaling in the Brain ↗
Comprehensive review covers 40 years of endocannabinoid signaling research in the brain, highlighting its profound influence on nervous system function.
Cannabinoids as Add-On Therapy for Treatment-Resistant MS Spasticity: A Systematic Review ↗
Systematic review supports cannabinoids as effective and safe add-on therapy for treatment-resistant spasticity in multiple sclerosis patients.
CBD and the Immune System: Extensive Preclinical Evidence, Zero Clinical Trials ↗
CBD consistently suppressed immune responses across animal and cell studies, but zero clinical trials have tested whether this helps humans with inflammatory diseases.
How Childhood Trauma, Endocannabinoid Genes, and Anxiety Shape Brain Development in Children ↗
FAAH gene variation interacts with childhood trauma and anxiety to shape frontolimbic brain pathways, positioning the endocannabinoid system as a mediator of trauma effects.
How Exercise Interacts with the Endocannabinoid System ↗
Review reveals exercise activates the endocannabinoid system, potentially explaining runners high and exercises mood, pain, and anti-inflammatory benefits.
More CUD Symptoms Increase Likelihood of Getting Diagnosed and Treated in Primary Care ↗
Greater CUD symptom severity increases probability of primary care diagnosis and treatment, supporting routine cannabis screening integration.
Dopamine D2 Receptor Gene Variants and Their Link to Harmful Alcohol Use in Young Adults ↗
Dopamine D2 receptor gene variants linked to harmful alcohol use in young adults, with behavioral and psychological factors mediating the relationship.
Oral Cannabinoids May Reduce Inflammation in People with HIV on Treatment ↗
Pilot trial finds oral cannabinoids may reduce systemic inflammation and affect viral reservoirs in people with HIV on antiretroviral therapy.
What Happens the Day After Cannabis Use? A Systematic Review ↗
Systematic review finds next-day cannabis effects are possible but inconsistent, varying by dose, use frequency, and cognitive domain assessed.
Do Medical Cannabis Laws Change How Doctors Treat Chronic Pain? ↗
Study examines whether medical cannabis laws change opioid and pain medication prescribing patterns for chronic non-cancer pain.
Cannabis-Using Gamblers Show Different Gambling and Mental Health Patterns ↗
Canadian national data shows cannabis-using gamblers have more severe gambling problems, higher substance use, and worse mental health than non-using gamblers.
What New Medical Cannabis Patients Say After One Month: Most Report It Helps Their Chronic Pain ↗
After one month, 63% of new medical cannabis patients reported effective pain relief, plus reduced medication use, less anxiety, and better sleep — though finding the right product was a common struggle.
How Young Adults Perceive Higher-Risk Cannabis Use Behaviors ↗
Young adults show variable awareness of higher-risk cannabis behaviors, with some risks underestimated, challenging harm reduction communication strategies.
US Veterans Using Medical Cannabis as Alternative to Prescription and OTC Medications ↗
Veterans report using medicinal cannabis to replace prescription and OTC medications for pain and mental health, highlighting need for VA system integration.
The Effects of Marijuana Use During Pregnancy on the Developing Baby ↗
Review examines marijuana impacts during pregnancy, noting some effects emerge at birth while others only appear during long-term childhood follow-up.
What Medical Cannabis Billboards in Oklahoma Are Saying to the Public ↗
Study analyzes medical cannabis billboard content in Oklahoma, finding variable regulatory compliance and messaging that could normalize cannabis use.
How Brain Cannabinoid Receptors Drive Stress-Induced Cocaine Seeking in Rats ↗
Mesolimbic CB1 receptors mediate stress-driven cocaine seeking in rats, identifying a specific endocannabinoid target for relapse prevention.
Violent Behavior, Self-Concept, and Substance Use Among High School Students ↗
Study models links between violent behavior, self-concept, and teen substance use, finding physical activity provides protective benefits.
Fewer Criminal Justice Referrals to Cannabis Treatment After Legalization ↗
Criminal justice referrals to cannabis treatment declined for teens and young adults after recreational legalization, changing how youth enter treatment.
How Cannabis Legalization Changes Risk Perception and Treatment Patterns Among Youth ↗
Cannabis legalization changes how youth perceive risk and relate to CUD treatment, requiring adapted public health responses.
How Pregnant Individuals Choose Cannabis Delivery Methods During Early Pregnancy ↗
Focus groups reveal pregnant individuals preferences for specific cannabis delivery methods, shaped by perceived safety and symptom needs.
Cannabis Use After Residential Substance Use Treatment Among US Veterans ↗
Study identifies treatment factors predicting cannabis use after residential SUD treatment in veterans, informing intervention during residential stays.
Cannabinoids, Cryotherapy, and Scalp Cooling: Improving Quality of Life During Chemo ↗
Review examines cannabinoids for nausea, cryotherapy for neuropathy, and scalp cooling for hair loss as complementary strategies to improve chemotherapy quality of life.
Which Kids Start Using Cannabis Before Age 13? An ABCD Study Analysis ↗
Using the large ABCD study cohort, researchers identified characteristics associated with early-onset cannabis use before age 13, including individual, family, and environmental risk factors.
Prenatal Cocaine Exposure Linked to Substance Use Disorder at Age 21 ↗
Longitudinal study finds prenatal cocaine exposure associated with substance use disorder at age 21, showing lasting developmental impact.
Brain Immune Cells CB2 Receptors Help Control Neuroinflammation ↗
Microglial CB2 receptor expression regulates neuroinflammation, with therapeutic potential for immunotherapy complications and neurodegenerative conditions.
THC Causes Cell Death and Inflammation in Rat Brain Cerebellum ↗
THC causes cell death markers, microglial changes, and astrocyte reactivity in rat cerebellum, showing neurotoxic and inflammatory effects.
Mental Health and Substance Use ER Visits During COVID-19 in Nevada ↗
COVID-19 pandemic altered patterns of mental health and substance use ER visits in Nevada, with complex increases and decreases across conditions.
People Who Use Drugs Are Using Cannabis to Reduce Harm from Other Substances ↗
Cohort study finds people who use drugs deliberately use cannabis to reduce harm from more dangerous substances when evidence-based services are limited.
Does ADHD Stimulant Treatment Affect Later Substance Use? Long-Term Data ↗
MTA study data examines whether childhood ADHD stimulant treatment is associated with later substance use through adolescence and early adulthood.
Cannabis Use in Adolescents with ADHD and Other Mental Health Disorders ↗
Clinical review addresses the complex overlap of cannabis use with ADHD and other psychiatric disorders in adolescents, emphasizing comprehensive assessment needs.
Cannabis Use in Adolescents with ADHD and Other Mental Health Disorders (Duplicate) ↗
Duplicate entry addressing cannabis use comorbidity with ADHD and other psychiatric disorders in adolescents.
Chestnut-Hemp Sourdough Improves Gluten-Free Bread Quality and Nutrition ↗
Chestnut-hemp sourdough improves gluten-free bread texture, nutrition, and taste while keeping ingredient lists clean.
Prenatal and Postnatal Cannabis Exposure Linked to Cognition and Behavior at Age 5 ↗
Healthy Start Study links both prenatal and postnatal cannabis exposure to cognitive and behavioral outcomes at age 5, highlighting risks beyond pregnancy.
How Minor Cannabinoids Move Through Blood and Reach the Brain After Oral Use ↗
Study characterizes how minor cannabinoids (THCV, CBC, CBN, delta-8-THC) distribute through blood and brain after oral consumption.
Early-Onset Frontotemporal Dementia Following Long-Term Cannabis Abuse: A Case Report ↗
Case report documents early-onset frontotemporal dementia after chronic cannabis abuse, raising questions about cannabis-neurodegeneration links.
THC and CBD for Tourette Syndrome: A Double-Blind Clinical Trial ↗
Double-blind trial tests THC with CBD for Tourette syndrome, building on preliminary evidence that cannabinoids may reduce tics.
Prenatal Cannabis Exposure: A Path to Later-Life Mental Health Problems ↗
Review shows prenatal cannabis exposure linked to mental health problems from childhood through adulthood, mediated by endocannabinoid system disruption.
Comparing Extraction Methods for Bioactive Compounds from Hemp Flowers ↗
Study compares extraction solvents for hemp flower bioactive compounds, finding solvent choice affects both yield and antimicrobial activity.
Cannabis Use and Type 2 Diabetes Risk: A Systematic Review and Meta-Analysis ↗
Meta-analysis finds mixed evidence on cannabis and type 2 diabetes risk, with complex metabolic interactions through glucose and insulin pathways.
Designing New Selective CB2 Receptor Drug Compounds Through Systematic Chemical Modification ↗
Medicinal chemistry study discovers new CB2-selective compounds through systematic scaffold modification, advancing cannabinoid drug development.
CANNA-TICS Trial: Nabiximols (Sativex) for Chronic Tic Disorders Phase III Results ↗
CANNA-TICS phase III trial provides the most rigorous evidence yet for nabiximols (Sativex) treatment of chronic tic disorders including Tourette syndrome.
How Prenatal Cannabis Exposure Influences Early Development and Beyond ↗
Review highlights disconnect between public belief that cannabis is safe during pregnancy and scientific evidence of developmental impacts.