Zebrafish as a Research Model for Studying Cannabinoid Effects ↗
Review highlights zebrafish as a valuable model for cannabinoid research, offering advantages in high-throughput screening and developmental studies.
Research library — page 75
Browse more cannabis research, findings, methods, and limitations.
Cannabis Use May Help Retain Patients on Lower Methadone Doses in Treatment ↗
Cannabis use may help patients on lower methadone doses remain in treatment, suggesting a potential moderating role in opioid use disorder care.
Cannabis Use May Reduce Illicit Opioid Use Among People on Methadone Treatment ↗
Cannabis use was associated with less illicit opioid use among methadone patients on lower doses, suggesting potential as a harm reduction adjunct.
Modeling Liver Safety of CBD and Valproate Alone and Combined ↗
Computational model confirms CBD and valproate combination increases liver enzyme elevation risk, explaining clinical observations of hepatotoxicity.
What Cancer Patients Discuss Online About Traditional and Complementary Medicine ↗
Mining over 1 million web posts reveals extensive cancer patient interest in complementary medicine including cannabis, highlighting information gaps.
Long-Lasting Brain Metabolism Changes from Morphine Withdrawal After Adolescent Cannabinoid Exposure in Rats ↗
Adolescent cannabinoid exposure in rats produced sex-dependent, long-lasting changes in brain metabolism during morphine withdrawal in adulthood.
Adolescent Risk Factors That Predict Adult Alcohol, Cannabis, and Other Substance Problems ↗
Adolescent risk factors including peer use and early initiation predict adult substance problems across two independent longitudinal samples.
Understanding Cyclic Vomiting Syndrome and Cannabis Hyperemesis Syndrome ↗
Review compares cyclic vomiting syndrome and cannabis hyperemesis syndrome, two conditions sharing severe episodic vomiting but differing in cause and treatment.
Do Standard Addiction Criteria Apply to Patients Prescribed Cannabis for Chronic Pain? ↗
International physician survey finds standard addiction criteria poorly fit patients prescribed cannabis for chronic pain, raising diagnostic concerns.
Comparing Acute Cannabis Effects in Teens vs Adults, With and Without CBD ↗
Rare randomized trial compares acute cannabis effects in teens vs adults and tests whether CBD modulates these effects differently by age.
Cannabis Use and Psychotic Disorders in Latin America, Asia, and Africa ↗
Multi-site Global South study confirms cannabis-psychosis associations are not limited to Western populations, expanding the global evidence base.
Mapping Terpene Profiles in Hybrid Cannabis Leaves and Flowers ↗
Analytical study maps distinct terpene profiles in cannabis leaves vs flowers, advancing understanding of the entourage effect.
CBD Treatment May Improve Cognitive Function in People with Cannabis Use Disorder ↗
Four weeks of CBD treatment showed cognitive improvements in cannabis use disorder patients, adding potential dual benefit to CUD treatment.
Combined Prenatal Alcohol and THC Exposure Impairs Spatial and Working Memory in Animal Model ↗
Animal study shows combined prenatal alcohol and THC exposure impairs spatial and working memory, with potentially distinct effects from either alone.
What Distinguishes Teens Who Use Marijuana Frequently from Those Who Dont ↗
Multilevel analysis reveals distinct risk and protective factors that differentiate frequent from non-frequent marijuana use in high school students.
Cannabis Use After First-Episode Schizophrenia: Does It Trigger Relapse? ↗
OPTIMISE study data examines whether cannabis triggers relapse in first-episode schizophrenia or whether symptom recurrence drives cannabis use.
Comparing Three Screening Tools for Youth Substance Use Disorders ↗
Study compares three brief screening tools for adolescent substance use disorders, evaluating which performs best for clinical identification.
Establishing a Safety Threshold for CBD Liver Toxicity Using Human Liver Cell Models ↗
Human liver cell model establishes CBD concentration thresholds for hepatotoxicity, providing quantitative safety data for dosing guidelines.
How the Cannabinoid System May Impact Alzheimers Disease ↗
Review explores how the endocannabinoid system may influence Alzheimers disease, highlighting cannabinoid therapeutic potential for neuroinflammation and neurodegeneration.
How Parenting Practices Relate to Teen Alcohol and Cannabis Use in Chile ↗
Chilean study finds parenting practices like monitoring and communication are associated with teen alcohol and cannabis use, informing Latin American prevention.
Can Chronic Cannabis Use Cause Fainting? A Case Report on Cannabis-Related Syncope ↗
Case report documents fainting (syncope) associated with chronic cannabis use, proposing excessive vagal nerve activation as the mechanism.
Israeli Physicians Attitudes and Knowledge About Opioid Maintenance Treatment ↗
Survey reveals variable knowledge and stigmatizing attitudes toward opioid maintenance treatment among Israeli specialist physicians.
What Do Cannabis Users Want from Addiction Treatment? A Pilot Survey ↗
Pilot survey reveals cannabis users treatment preferences for use disorder, highlighting gaps between patient wants and available interventions.
Why Pregnant Individuals Should Pause Cannabinoid Use During Pregnancy ↗
Review argues for clear medical messaging that pregnant individuals should pause all cannabinoid use, citing growing fetal risk evidence.
Substance Use Disorders in Older Adults: A Growing Problem in a Growing Population ↗
Review examines the growing problem of substance use disorders in older adults, highlighting unique diagnostic and treatment challenges in this population.
Cannabinoids as Potential Treatments for Traumatic Brain Injury ↗
Review examines cannabinoids (endogenous, plant, and synthetic) as potential TBI treatments, noting neuroprotective properties and the absence of approved alternatives.
Regular Cannabis Use Linked to Reduced Anaerobic Power in Female Athletes ↗
Female athletes who regularly use cannabis showed reduced early anaerobic power, suggesting performance impact in explosive activities.
Major State-Level Differences in Cannabinoid Prescribing to Medicaid Patients ↗
Study reveals major state-level disparities in prescribing FDA-approved cannabinoids to Medicaid patients, highlighting inequitable access.
Marijuana Vaporizer Aerosol Impairs Blood Vessel Function Similar to Smoke ↗
Marijuana vaporizer aerosol impairs blood vessel function similarly to smoke, challenging the perception that vaporizing is significantly safer for cardiovascular health.
CBD as a Harm Reduction Tool for People Who Use Drugs ↗
Rapid review finds emerging evidence for CBD as a harm reduction tool for problematic substance use, with potential across multiple drug categories.
Blood Neurotrophin Levels May Predict Transition to Mental Disorders in At-Risk Youth ↗
Blood neurotrophin levels may predict transition to mental disorders in individuals at ultra-high risk for psychosis, offering potential biomarker applications.
How ADHD Symptoms and Sex Affect Cannabis Harm-Reduction Strategies in College Students ↗
ADHD symptoms and sex moderate the effectiveness of cannabis protective strategies, suggesting harm reduction may need tailoring for neurodivergent students.
Delta-8 THC: The Legal-Loophole Cannabinoid That's Booming with Minimal Research ↗
Delta-8 THC boomed after the 2018 Farm Bill accidentally legalized it, but this scoping review found almost no human safety data behind the millions of products being sold.
Cannabinoids as Emerging Sleep Modulators ↗
Review explores how different cannabinoids modulate sleep through the endocannabinoid system, with potential as new sleep disorder treatments.
CBG Reduced Inflammation in Rheumatoid Arthritis Cells Through a Pain-Sensing Channel ↗
CBG reduced key inflammatory markers in rheumatoid arthritis cells through the TRPA1 pain-sensing channel, with selectivity for inflamed over healthy tissue.
How CBD Affects Immune Cells and Rheumatoid Arthritis Tissue in the Lab ↗
Lab study shows CBD has anti-inflammatory effects on B cells and immune cells in rheumatoid arthritis tissue co-cultures, clarifying therapeutic mechanisms.
CBDs Medical Potential Beyond Pain: A Comprehensive Review ↗
Comprehensive review examines CBDs therapeutic potential across neurological, psychiatric, inflammatory, and cardiovascular conditions beyond pain relief.
Hemp Seed Oil May Help Perimenopausal Depression Through Stress Hormone Regulation ↗
Hemp seed oil showed antidepressant effects in perimenopausal depression model through HPA axis regulation and estrogen-like activity.
Cannabis Use Disorder May Impair Brain Error Processing and Self-Awareness of Addiction ↗
Brain error processing is impaired in cannabis use disorder and correlates with reduced self-awareness of addiction, helping explain low treatment-seeking.
A Clinical Guide for Evaluating Cannabis Product Quality and Safety ↗
Clinical framework helps healthcare providers evaluate cannabis product quality and safety, addressing a practical gap in medical cannabis care.
CBD Treatment Effects on Pain Sensitivity in Rats Bred for High vs Low Anxiety ↗
CBD effects on neuropathic pain differ by anxiety phenotype in rats, supporting personalized approaches to cannabinoid pain treatment.
Overview of Methods to Detect and Measure Cannabinoids in Cannabis Products ↗
Comprehensive overview of analytical methods for detecting and quantifying cannabinoids in cannabis products, supporting regulatory and safety needs.
Cannabis Use and Bipolar Disorder: A Systematic Review and Meta-Analysis ↗
Meta-analysis finds associations between cannabis use and bipolar disorder onset and clinical features, extending the cannabis-mental health evidence base.
Current Cigarette Smoking Linked to Worse Cognitive Performance in Schizophrenia ↗
Current smoking is linked to worse cognition in stabilized schizophrenia, challenging the self-medication hypothesis that nicotine helps thinking.
Efficiently Isolating Pure CBD and CBDA from Hemp Without THC Contamination ↗
Fast centrifugal partition chromatography effectively isolates pure CBD and CBDA from hemp extract while removing all THC contamination.
Developing Evidence-Based Guidelines for Cannabis and Driving Safety ↗
Review examines the evidence base for cannabis driving safety policies, highlighting challenges in connecting THC levels to actual impairment.
Cannabis Use Disorder Rising Among US Veterans with Chronic Pain ↗
Cannabis use disorder rates increased among US veterans with chronic pain from 2005-2019, highlighting risks of expanded cannabis access in pain populations.
Testing How a Medical Cannabis Product Affects Simulated Driving and Eye Movement ↗
Randomized trial tests how a standardized medical cannabis dose affects simulated driving and eye movement, informing fitness-to-drive guidelines.
Hemp Roots Activate Heavy Metal Transport Genes When Exposed to Cadmium ↗
Hemp roots upregulate heavy metal transporter genes when exposed to cadmium, providing molecular insight into phytoremediation potential and contamination risk.
Users Describe Synthetic Cannabinoid Addiction as Made by the Devil ↗
Users describe synthetic cannabinoid addiction as profoundly more severe than natural cannabis, with intense compulsion and physical dependence themes.