Medical Cannabis Improved Quality of Life, Anxiety, and Sleep in ADHD Patients Over 12 Months ↗
UK registry data from 68 ADHD patients shows medical cannabis associated with improved quality of life, reduced anxiety, and better sleep over 12 months.
Research library — page 74
Browse more cannabis research, findings, methods, and limitations.
E-Cigarette and Cannabis Use Together Are Linked to Higher Depression and Suicide Risk in High Schoolers ↗
Among 12,401 US high schoolers, concurrent e-cigarette and cannabis use was linked to elevated depression, suicidal ideation, and suicide attempts, especially in females.
Marijuana Use Does Not Worsen Bariatric Surgery Outcomes ↗
Study of 6,879 bariatric patients finds marijuana use did not worsen surgical outcomes or weight loss, but users had higher rates of depression and other substance use.
Developing a Cannabis Breathalyzer: THC Detected in Breath After Smoking ↗
Pilot study detected THC in 80% of breath samples after cannabis smoking, but 31-36% baseline detection rates highlight challenges for cannabis breathalyzer development.
CBD Can Convert Into THC and Other Psychoactive Compounds Under Acidic Conditions ↗
Chemistry study shows CBD converts to THC and six other psychoactive compounds under acidic conditions, with implications for CBD product manufacturing safety.
A New Drug Blocks Pain and Inflammation by Boosting Endocannabinoids Without Brain Side Effects ↗
Novel peripherally restricted MAGL inhibitor LEI-515 reduced pain and inflammation through CB2 receptors without brain side effects or dependence in mice.
Cannabis Terpenes Reduce Anxiety in Zebrafish Through CB2 Receptors ↗
Zebrafish study shows terpinolene and beta-caryophyllene reduce anxiety through CB2 (not CB1) receptors, providing experimental support for the cannabis entourage effect.
Genetic Risk for Schizophrenia Predicts Unusual Experiences From Cannabis Use ↗
Genetic risk for schizophrenia predicts more paranoia, depression, and cognitive difficulties from cannabis, even without clinical psychosis (replicated in independent sample).
Cannabis Terpene Beta-Myrcene Impaired Driving Simulator Performance ↗
Pilot study shows the cannabis terpene beta-myrcene impaired speed control and divided attention on a driving simulator without any cannabinoids.
Poor Diet, Sitting, Cannabis, and Tobacco Are All Equally Linked to Mental Health Disorders ↗
Review of 294 studies finds poor diet, sedentary behavior, cannabis, and tobacco are equally strongly associated with multiple mental disorders, suggesting shared underlying causes.
Cannabis Legalization Reduced Possession Arrests but Created New Racial Disparities in Public Consumption Arrests ↗
Cannabis legalization reduced possession arrest racial gaps in DC and LA, but new public consumption arrests emerged with significant racial disparities.
Unraveling the Complex Sex Determination System of the Hemp Palm ↗
Genetic study of the hemp palm reveals unstable sexual expression and evolution toward XY sex determination, explaining its invasive success in European Alps.
Most Psychosis Outpatients Need Health Promotion but Only 40% Receive It ↗
73% of psychosis outpatients needed health promotion for BMI, smoking, or substance use, but 61% received no health-promoting care.
How to Make Stable Cannabis Skin Creams: An Extraction and Stability Guide for Pharmacies ↗
Study finds olive oil and Synderman bases offer best cannabinoid extraction (~70%) and stability for pharmacy-prepared topical cannabis formulations.
ADHD-Cannabis Link in Swedish Teens Explained by Conduct Problems and Sensation-Seeking ↗
Swedish study finds the ADHD-cannabis link is largely explained by conduct problems, which themselves are driven by sensation-seeking traits.
Genetic Analysis Shows No Causal Link Between Cannabis Use and Glaucoma ↗
Mendelian randomization with large GWAS data finds no causal link between cannabis use or cannabis use disorder and primary open-angle glaucoma.
First Case of Cannabinoid Hyperemesis Syndrome Caused by Prescription CBD for Epilepsy ↗
First reported case of cannabinoid hyperemesis syndrome from prescription CBD in a child with epilepsy, resolving after CBD discontinuation without seizure worsening.
How Older Adults Use Cannabis for Sleep: Patterns from a Geriatrics Clinic ↗
Geriatrics clinic survey found elderly cannabis users treating sleep problems prefer THC over CBD, use daily, and take it right before bed — often without clinician guidance.
Non-Psychoactive Cannabinoids Show Promise Against Ovarian Cancer in Preclinical Studies ↗
Review highlights non-psychoactive cannabinoids as promising anti-cancer agents for ovarian cancer with excellent tolerability in preclinical studies.
The Paradox of Cannabis and Cognition in Schizophrenia: It Is Complicated ↗
Review explores the paradox that cannabis-using schizophrenia patients show better cognition than non-users, despite cannabis worsening psychotic symptoms.
Childhood Trauma and Suicide Attempts Together Amplify Adolescent Drinking but Not Cannabis Use ↗
Study of 1,625 high schoolers finds childhood trauma and suicide attempts interact to amplify drinking, but independently predict cannabis use.
Combined Binge Drinking and Cannabis Use Surged 450% Among Adults 65+ From 2015-2019 ↗
Combined binge drinking and cannabis use among adults 65+ surged 450% from 2015-2019, driven by the Baby Boomer generation changing attitudes.
Cannabis-Induced Anxiety Affected 17% of ER Patients With Cannabis Toxicity After Michigan Legalization ↗
After Michigan legalization, 17.3% of 1,135 cannabis toxicity ER visits involved anxiety, with edible users and younger patients at higher risk.
Cannabis Hyperemesis Syndrome in a Young Diabetic Patient: Case Report ↗
Case report of CHS in a 25-year-old with type 1 diabetes highlights diagnostic challenges and the importance of considering cannabis as a cause of recurrent vomiting.
Cannabis Users Had Lower Opioid Doses but Higher Addiction Risk After Spine Surgery ↗
Spine surgery study: cannabis users needed lower opioid doses but were 5x more likely to develop opioid use disorder, suggesting addiction vulnerability.
Tobacco and Cannabis Had Mild Effects on Sperm and Hormones in Infertile Men ↗
Study of 160 infertile men finds cannabis significantly elevated FSH, with mild, non-significant effects on sperm count, testosterone, and LH.
Racial Disparities in Prenatal Tobacco and Cannabis Exposure After California Legalization ↗
Biomarker study of 925 pregnant individuals finds significant racial disparities in cannabis and tobacco exposure after California legalization.
Pregnant Women Who Use Cannabis Rely on Internet and Peers, Not Doctors, for Information ↗
Qualitative study of 15 women reveals pregnant cannabis users avoid discussing use with providers, relying instead on internet and peers for information.
Medical Marijuana Access Did Not Reduce Post-Surgical Opioid Use in Teens and Young Adults ↗
Large study of 195,204 young surgical patients finds no reduction in prolonged opioid use associated with medical marijuana access.
Most Spinal Cord Injury Patients Report Cannabis Reduces Their Neuropathic Pain and Medication Use ↗
Survey of 227 SCI patients finds 88% reported >30% pain reduction from cannabis and 83% substituted pain medications including opioids.
Cannabinoid Hyperemesis Syndrome in Pregnancy: A Difficult Diagnostic and Treatment Challenge ↗
Clinical perspective explores the unique challenges of diagnosing and treating cannabinoid hyperemesis syndrome during pregnancy.
A Quick Leaf Test for Screening Cannabis Disease Resistance and Treatment Efficacy ↗
Validated detached leaf assay provides quick screening of cannabis varieties for Botrytis resistance and treatment product efficacy.
Only 30% of Pregnant Women Complete Cannabis Use Disorder Treatment ↗
Only 30% of pregnant women completed CUD treatment, with criminal justice and healthcare provider referrals significantly improving completion rates.
Older Adults Value Cannabis as Medicine but Rarely Discuss It With Their Doctors ↗
Pilot survey of 47 older adults finds 76% value cannabis for treatment but only 23% were asked about it by their doctor, relying instead on internet sources.
Cannabis May Help HIV Patients Cope With Pain Impact, Not Pain Itself ↗
Cannabis did not reduce pain directly in HIV patients but attenuated how much pain severity interfered with daily functioning.
Novel Compounds Activate Unknown Cannabinoid-Like Receptors Distinct From CB1 and CB2 ↗
Fourteen novel compounds activate unidentified cannabinoid-like receptors (not CB1 or CB2) with low-nanomolar potency, providing new research tools.
CBD Reduced Seizures in 87% of Adults With Drug-Resistant Focal Epilepsy ↗
Open-label study of 44 adults with drug-resistant focal epilepsy found CBD reduced seizures 50%+ in 87%, with significant quality of life improvements and no severe side effects.
A Free Online Tool for Checking Cannabis Drug Interactions ↗
CANN-DIR is a free, 10-language web platform that screens cannabinoid drug interactions using FDA data, filling a gap for non-prescription CBD users.
Prenatal Tobacco and Cannabis Co-Exposure Linked to Childhood Obesity Risk ↗
Prenatal co-exposure to tobacco and cannabis may increase childhood obesity risk beyond either substance alone.
Could Medicinal Cannabis Help Manage Challenging Behavior in People with Intellectual Disabilities? ↗
Review explores medicinal cannabis as a potential option for challenging behavior in intellectual disability, noting limited but promising theoretical pathways.
Blood Cannabinoid Metabolite Ratios Are Better Than THC Alone at Indicating Recent Cannabis Use ↗
Blood cannabinoid metabolite ratios outperform THC alone as indicators of recent cannabis use, potentially improving impairment testing accuracy.
Substance Use Patterns Among Psychiatric Emergency Patients in an Urban County ↗
Chart review reveals high rates of substance use among psychiatric emergency patients, emphasizing the need for integrated dual-diagnosis care.
How Canadian Youth Cannabis Use Has Changed Post-Legalization, According to Service Providers ↗
Canadian service providers report youth cannabis use has not declined post-legalization, raising concerns about whether policy objectives are being met.
How Combined Alcohol and Cannabis Exposure During Development Affects Offspring ↗
Review explores how combined alcohol and cannabis exposure during pregnancy may produce unique developmental effects through overlapping neurobiological mechanisms.
Gender Differences in Cannabis Use Disorder Symptoms Revealed Through Network Analysis ↗
Network analysis shows CUD symptoms connect differently in men and women, suggesting gender-specific treatment approaches may be more effective.
How Attention Bias, Craving, and Self-Control Interact in Cannabis Users ↗
Attentional bias toward cannabis cues interacts with craving and cognitive control, with associations linked to use severity.
What Social Media Reveals About THC-O-Acetate Use and Experiences ↗
Social media analysis reveals active consumer interest in THC-O-acetate despite minimal safety research, highlighting gaps between market availability and scientific knowledge.
Consumer Experiences with Delta-8-THC: Medical Uses and Comparisons to Delta-9-THC ↗
Consumers report delta-8-THC provides medical benefits similar to delta-9-THC but with milder psychoactive effects and fewer side effects.
Real-World Evidence Shows CBD Helps Various Epilepsy Types Beyond Approved Indications ↗
Multicenter study finds CBD shows antiseizure effects across epilepsy subtypes beyond its three approved indications.
How Daily Substance Use Relates to Symptom Changes in Fibromyalgia ↗
Daily diary study reveals temporal links between substance use (including cannabis) and somatic symptom changes in fibromyalgia patients.