Cannabis Use in SUD Treatment Patients Was Linked to More Trauma and Worse Mental Health

Among 544 patients seeking substance use disorder treatment, those currently using cannabis had higher rates of trauma history, psychiatric diagnoses, and suicidality than lifetime or never users.

Matheson, Justin et al.·Substance use & misuse·2025·Moderate EvidenceCross-Sectional
RTHC-07084Cross SectionalModerate Evidence2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Cross-Sectional
Evidence
Moderate Evidence
Sample
N=363

What This Study Found

Cannabis use was significantly associated with trauma history and several psychiatric diagnoses including anxiety and depression, with the highest prevalence in current users. However, cannabis use was not independently associated with anxiety, depression, sleep quality, or disability scores after controlling for trauma exposure, suggesting trauma may mediate the relationship.

Key Numbers

N = 544. Current users: 363, past users: 109, never users: 72. Trauma and psychiatric diagnoses significantly associated with cannabis group. Anxiety, depression, sleep, and disability scores not independently associated with cannabis use after adjusting for trauma.

How They Did This

Cross-sectional online survey of 544 patients in Ontario, Canada seeking SUD treatment. Participants grouped by cannabis use: current (past-year, n=363), past (lifetime but not past-year, n=109), and never (n=72). Validated measures assessed GAD-7, PHQ-9, PSQI, WHODAS, psychiatric diagnoses, trauma, and suicidality.

Why This Research Matters

Understanding the mental health profile of cannabis users in SUD treatment is essential for tailoring care. The finding that trauma may explain much of the cannabis-mental health link suggests that trauma-informed approaches could be more effective than focusing on cannabis use alone.

The Bigger Picture

The high overlap between cannabis use, trauma, and psychiatric comorbidity in SUD treatment populations suggests these issues need integrated rather than siloed treatment approaches.

What This Study Doesn't Tell Us

Cross-sectional design prevents causal inference. Self-reported measures may be subject to recall bias. Ontario-specific treatment population may not generalize. Current cannabis use was not distinguished from cannabis use disorder.

Questions This Raises

  • ?Would trauma-focused therapy reduce cannabis use in this population?
  • ?Is cannabis use a consequence of, or a coping response to, trauma and mental illness?

Trust & Context

Key Stat:
Trauma may mediate the cannabis-mental health link in SUD patients
Evidence Grade:
Moderate-sized cross-sectional study with validated clinical measures. Cannot determine causation.
Study Age:
Published in 2025.
Original Title:
Associations Between Cannabis Use and Mental Health in Patients Accessing Treatment for Substance Use Disorders: An Exploratory Cross-Sectional Study.
Published In:
Substance use & misuse, 60(12), 1883-1891 (2025)
Database ID:
RTHC-07084

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study

A snapshot of a population at one point in time.

What do these levels mean? →

Frequently Asked Questions

Does cannabis make mental health worse in people with addiction?

This study found an association but suggests trauma history, rather than cannabis itself, may explain the worse mental health among cannabis-using SUD patients.

Should SUD treatment programs address cannabis use?

Yes, but this study suggests trauma-informed approaches may be more effective than focusing on cannabis reduction alone, since trauma appears to drive much of the mental health burden.

Read More on RethinkTHC

Cite This Study

RTHC-07084·https://rethinkthc.com/research/RTHC-07084

APA

Matheson, Justin; MacKillop, James; Sloan, Matthew E; Sanches, Marcos; Saini, Harseerat; Haines-Saah, Rebecca; Zaweel, Adam; Hassan, Ahmed; Buckley, Leslie; Porath, Amy; Hendershot, Christian S; Kloiber, Stefan; Le Foll, Bernard. (2025). Associations Between Cannabis Use and Mental Health in Patients Accessing Treatment for Substance Use Disorders: An Exploratory Cross-Sectional Study.. Substance use & misuse, 60(12), 1883-1891. https://doi.org/10.1080/10826084.2025.2519419

MLA

Matheson, Justin, et al. "Associations Between Cannabis Use and Mental Health in Patients Accessing Treatment for Substance Use Disorders: An Exploratory Cross-Sectional Study.." Substance use & misuse, 2025. https://doi.org/10.1080/10826084.2025.2519419

RethinkTHC

RethinkTHC Research Database. "Associations Between Cannabis Use and Mental Health in Patie..." RTHC-07084. Retrieved from https://rethinkthc.com/research/matheson-2025-associations-between-cannabis-use

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.