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Study breakdown

Mixing tobacco with cannabis is linked to nicotine dependence in young adults

Longitudinal CohortModerate evidence
The takeaway

Nearly half of young adult cannabis users mix tobacco with cannabis, and mixing more frequently was associated with greater nicotine dependence even after accounting for other nicotine sources.

Young adult cannabis users, tobacco cessation counselors, and public health researchers.

48% of cannabis users mixed tobacco with cannabis

What the researchers found

Of 313 past-year cannabis users (mean age 30.6), 48% reported mixing tobacco with cannabis. Weekly or daily mixing was associated with endorsing 0.5 more ICD-10 nicotine dependence criteria, and less-than-weekly mixing with 0.3 more criteria, after controlling for cigarettes smoked, other tobacco products, and secondhand smoke exposure.

Why it matters

Mixing tobacco with cannabis creates an often-overlooked source of nicotine exposure that could make quitting tobacco harder for young adults who use both substances.

The numbers in context

788 participants total, 313 past-year cannabis users, 150 (48%) reported mixing. Weekly/daily mixers: 0.5 additional ND criteria. Less than weekly mixers: 0.3 additional criteria.

How the study worked

Longitudinal cohort study of 788 young adults (2017-2020) using self-report questionnaires. Multivariable logistic regression identified characteristics of mixers. Nicotine dependence was measured using ICD-10 criteria.

What this study cannot tell us

Self-reported measures. Longitudinal design but nicotine dependence analysis was cross-sectional within the cannabis-using subsample. Canadian context where mixing may be more common than in the U.S.

How to read the evidence

Longitudinal cohort with appropriate controls for other nicotine sources, though the mixing-dependence analysis was cross-sectional.

When this study was published

Published in 2022 with data from 2017-2020.

The bigger picture

Tobacco control efforts may be undermined if cannabis-tobacco mixing is not recognized as an independent pathway to nicotine dependence, especially in regions where mixing is culturally common.

Questions still open

  • Would reducing tobacco-cannabis mixing rates improve tobacco cessation outcomes? Are cannabis users who mix aware of the nicotine dependence risk?

Common questions

Who is most likely to mix tobacco with cannabis?
Younger age, lower education and income, past-year cigarette use, other tobacco and illicit drug use, poor coping skills, and gambling were all associated with mixing.
Does mixing make nicotine dependence worse?
Yes. Even after accounting for cigarettes smoked, other tobacco products, and secondhand smoke, mixing tobacco with cannabis was independently associated with more nicotine dependence symptoms.

Read the original research

Who mixes tobacco with cannabis and does mixing relate to nicotine dependence?

Addictive behaviors, 128, 107254

Citation

Dugas, Erika N; Wellman, Robert J; Sylvestre, Marie-Pierre; Bélanger, Richard E; O'Loughlin, Jennifer. (2022). Who mixes tobacco with cannabis and does mixing relate to nicotine dependence?. Addictive behaviors, 128, 107254. https://doi.org/10.1016/j.addbeh.2022.107254

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