How Emergency Departments Handle Cannabis-Related Emergencies ↗
Clinical review outlining how emergency departments should diagnose and manage cannabis-related emergencies, distinguishing between natural and synthetic cannabinoid presentations.
Research library — page 121
Browse more cannabis research, findings, methods, and limitations.
Testing a Health Communication Tool to Reduce Cannabis Misuse in College Students ↗
Proof-of-concept study testing a technology-delivered health communication intervention to reduce cannabis misuse among 64 college students.
Vaping Cannabis Triggers Cancer, Inflammation, and Oxidative Stress Genes in Lung Cells ↗
Cannabis vapor activated cancer, inflammation, and oxidative stress genes in human lung cells—without triggering DNA damage, suggesting a unique harm mechanism.
How Cannabis Marketing Exposure Differs Across US States With Different Laws ↗
Large national survey of 187,573 people showing significantly higher cannabis marketing exposure in recreational-legal states compared to medical-only or prohibition states.
Placebo Effects May Explain Much of CBD's Reported Benefits for Stress ↗
Three-arm RCT finding that placebo effects account for significant improvements attributed to low-dose CBD oil for psychological distress in university students.
CBD May Protect Joint Cartilage Cells From a Specific Type of Cell Death ↗
Lab study showing CBD can protect human cartilage cells from ferroptosis (iron-dependent cell death), suggesting a potential mechanism for joint protection relevant to osteoarthritis.
Two Children Used Cannabis-Based Medicine for Tourette Syndrome for Five to Six Years ↗
Case report of two children with treatment-resistant Tourette syndrome who used cannabis-based medicine for 5-6 years, providing rare long-term pediatric follow-up data.
Cannabis Extract Shows Anti-Inflammatory Effects in a Rat Model of Dermatitis ↗
Preclinical study showing cannabis extract reduces inflammation in a rat dermatitis model, supporting potential applications for inflammatory skin conditions.
How CBD and Low-Dose THC From Hemp Products Affect Drug Tests and the Body ↗
Clinical trial in 60 adults showing that legal hemp CBD products containing trace THC can trigger positive drug tests, with effects depending on THC dose level.
How Starting Medical Cannabis Affects Anxiety and Depression Over Six Months ↗
Prospective cohort study finding that new medical cannabis patients with anxiety and depression showed improvements over 6 months using real-time symptom monitoring.
German Midwives' Knowledge and Practices Around Cannabis Use During Pregnancy ↗
Survey of German midwives after 2024 cannabis legalization finding gaps in knowledge about prenatal cannabis risks and inconsistent screening practices.
How Emergency Departments Treat Cannabinoid Hyperemesis Syndrome ↗
Review of current pharmacological and non-pharmacological treatments for cannabinoid hyperemesis syndrome in the emergency department setting.
How Eating Cannabis Edibles Affects Simulated Driving Performance ↗
Driving simulator study of 88 adults showing edible cannabis impairs driving performance, with effects varying by usage frequency and driving environment.
Drug Use in Non-Fatal Car Crashes and How Cannabis Policies Affect Crash Rates ↗
Analysis of drug use in non-fatal motor vehicle crashes in 2023, examining how state cannabis legalization policies relate to drug-positive crash rates.
Social and Environmental Factors That Predict When Youth First Try Alcohol vs. Cannabis ↗
Longitudinal study of 387 adolescents finding that social and environmental predictors of substance initiation differ for alcohol vs. cannabis, moderated by family addiction history.
Deleting an Endocannabinoid Enzyme Changes How Mice Respond to Stress ↗
Preclinical study showing that mice lacking the endocannabinoid enzyme NAPE-PLD have altered stress responses that depend on the type of stress context.
Mice Without NAPE-PLD Show Sex-Based Differences in Opioid and Reward Responses ↗
Preclinical study showing mice without the endocannabinoid enzyme NAPE-PLD have sex-dependent changes in opioid and natural reward responsiveness.
What Canadian Cannabis Retailers Think Is Working—and What Isn't—After Legalization ↗
Canadian cannabis retailers in Newfoundland cited high taxes, advertising restrictions, and supply chain issues as barriers—while recognizing their public health role.
Your Genes May Determine How Your Body Processes Cannabis—and Most People Have Atypical Variants ↗
Among 71 older cannabis users, 86% had genetic variants altering cannabinoid metabolism—explaining why the same dose affects people so differently.
Can CBD Help With Alzheimer's-Related Brain Inflammation? A Meta-Analysis ↗
Systematic review and meta-analysis showing CBD consistently reduces neuroinflammation in preclinical Alzheimer's models with promising but limited clinical signals.
Using Alcohol and Cannabis Together Changes How People Judge Their Driving Ability ↗
EMA study of 88 co-users finding that simultaneous alcohol and cannabis use paradoxically increases both perceived impairment and willingness to drive.
What We Know About Cannabis Use During Pregnancy and Breastfeeding ↗
Comprehensive review of cannabis use in pregnancy and breastfeeding, covering pharmacology, evidence on outcomes, and harm reduction counseling strategies.
What Nearly 3 Million Tweets Reveal About Americans' Cannabis Attitudes ↗
Deep learning analysis of 2.9 million cannabis tweets showing predominantly positive/neutral attitudes, with medical value and difficulty quitting as dominant positive and negative themes.
Potency-Based Cannabis Taxes Are Better at Reducing High-THC Product Demand ↗
Experimental marketplace study of 1,250 cannabis users showing potency-based taxes are more effective than price-based taxes at reducing demand for high-THC products.
Recreational Cannabis Laws Are Associated With People Sleeping About 5 Minutes Less ↗
Analysis of 175,493 Americans showing recreational cannabis legalization is associated with falling asleep 7 minutes later and sleeping 5 minutes less per night.
How Different Cannabis Tax Structures Affect Teen and Young Adult Purchasing ↗
Choice experiment with 1,100 youth showing cannabis taxes reduce consumption but potency-based taxes paradoxically increase low-THC product use and may drive illegal market substitution.
Scientists Map a Brain Circuit Where Endocannabinoids Reduce Anxiety ↗
Researchers mapped an amygdala-hippocampus brain circuit where endocannabinoids are naturally released during anxiety to dampen fear responses, using novel viral tools.
How Cyclic Vomiting Syndrome and Cannabinoid Hyperemesis Syndrome Overlap and Differ ↗
Clinical review clarifying how cyclic vomiting syndrome and cannabinoid hyperemesis syndrome overlap in symptoms but differ in causes and treatment approaches.
CBD Shows Antitumor Effects Against Bone Cancer by Targeting an Inflammatory Pathway ↗
Preclinical study showing CBD inhibits osteosarcoma growth by directly binding NF-kB and disrupting an inflammatory signaling loop, validated in cell and mouse models.
Cannabis Users Are More Sensitive to Cigarette Price Increases Than Non-Users ↗
Analysis of 15 years of national data showing cannabis-using smokers are significantly more responsive to cigarette price increases than non-cannabis-using smokers.
Cannabis Therapy Helped 91.5% of Nerve Pain Patients—and a Novel Biomarker Tracked Anxiety, Not Pain ↗
Cannabis therapy achieved 91.5% response in 200 neuropathic pain patients over 4 years—and a novel biomarker tracked anxiety 6x better than pain.
Scientists Identify the Brain Neurons Behind Cannabis-Induced Munchies ↗
Preclinical study showing cannabinoids drive appetite by activating AgRP hunger neurons in the brain, with neuron ablation eliminating the munchies effect.
Activating vs. Blocking CB1 Receptors Has Opposite Effects on Alzheimer's Pathology ↗
Six-month study in Alzheimer's mice showing CB1 receptor activation reduces tau pathology and neuroinflammation while blocking CB1 worsens all disease measures.
Cannabis Use Drove a Spike in Substance-Involved Child Welfare Cases During COVID ↗
Analysis of 264,380 Ohio child welfare cases showing substance involvement spiked from 32% to 42% in early 2020, driven by increases in cannabis and polysubstance use.
THC and CBD Both Suppress Immune B-Cells But Through Different Metabolic Pathways ↗
Preclinical study showing THC and CBD both suppress B-cell immune activation but through distinct metabolic pathways that differ between young and aged mice.
Cannabis-Like Compounds From Other Plants Show Promise Against Drug-Resistant Epilepsy ↗
Cannabis-like compounds magnolol and amorfrutin 2 from non-cannabis plants show antiseizure effects in Dravet and Lennox-Gastaut mouse models through T-type calcium channel inhibition.
Tobacco and Cannabis Smoke Are Both Linked to Lower Dopamine Receptor Levels ↗
PET imaging study of 29 people showing 13% lower dopamine D2 receptor availability in those testing positive for tobacco and/or cannabis smoke metabolites.
CBD Shows Promise Against One of the World's Most Drug-Resistant Bacteria ↗
Lab study showing CBD kills extensively drug-resistant A. baumannii and synergizes with antibiotics, reducing needed antibiotic concentrations by up to 1,000-fold through membrane disruption.
What Cannabis Budtenders Tell Pregnant Customers About Safety ↗
Mystery shopper study finding only 40% of California budtenders advise against prenatal cannabis use, while 80% warn against tobacco — highlighting a critical public health gap.
Frequent Cannabis Use Before Pregnancy Strongly Predicts Use During Pregnancy ↗
Large study of 40,806 pregnancies showing daily preconception cannabis use increases the risk of prenatal use 2.7-fold, highlighting the need for early intervention.
Prenatal Cannabis Use Is Linked to Earlier Breastfeeding Discontinuation ↗
Study of 200,207 pregnancies showing prenatal cannabis users initiate breastfeeding at similar rates but discontinue earlier, with 16-19% lower rates at 6-12 months.
Cannabis Use Before and During Pregnancy Is Linked to Worse Morning Sickness ↗
Analysis of 356,343 pregnancies finding daily cannabis use associated with 3.8x greater odds of severe morning sickness, challenging the use of cannabis for pregnancy nausea.
Prenatal Alcohol But Not Cannabis Use Linked to Infant Hearing Loss ↗
Study of 297,147 infants finding prenatal alcohol (but not cannabis or nicotine) exposure associated with 37% increased risk of infant hearing loss.
How Pregnant Cannabis Users Consume: Smoking Most Common, With Sociodemographic Differences ↗
Study of 3,507 pregnant cannabis users finding smoking is most common (71%), with significant sociodemographic differences in how cannabis is consumed during pregnancy.
Prenatal Cannabis Use Not Linked to ADHD or Behavior Disorders in Children ↗
Large study of 141,570 children finding no association between maternal prenatal cannabis use and ADHD or disruptive behavior disorders after adjusting for confounders.
Prenatal Cannabis Exposure Linked to Hallucinatory Experiences in Children ↗
ABCD Study analysis of 11,854 children finding prenatal cannabis exposure associated with 58% higher odds of hallucinatory-like psychotic experiences, distinct from genetically-driven paranoid symptoms.
CBG Confirmed as Non-Intoxicating Even at High Blood Concentrations ↗
Comprehensive mouse study confirming cannabigerol (CBG) is non-intoxicating at any blood concentration or route of administration, supporting its safety for wellness products.
Adolescent THC Exposure Disrupts Brain Myelination in Female Rats ↗
Preclinical study showing THC disrupts prefrontal cortex myelination in female rats during early adolescence, with intensive exposure causing permanent changes and increased risk-taking.
Canadian Nursing Students Report Major Knowledge Gaps About Cannabis ↗
Survey of 153 Canadian nursing students revealing 86-90% report knowledge gaps in cannabis regulations, effectiveness, and dosing practices.
Cannabis Use Disorder Is Strongly Linked to Generalized Anxiety Under DSM-5 Criteria ↗
Large national study finding GAD significantly associated with cannabis use disorder under DSM-5 criteria, with different patterns for lifetime vs. past-year diagnoses.