Browse more cannabis research, findings, methods, and limitations.
Among 80,787 hand fracture surgery patients, cannabis users had higher complication rates than non-users for infections, cardiac events, and malunion, though fewer complications than tobacco users.
A Wisconsin restaurant accidentally used hemp-derived THC cooking oil from a shared kitchen, causing 85 people to experience THC intoxication over three days in October 2024.
Among 1,242 people with chronic pain using illicit opioids in Vancouver, daily cannabis use was associated with 40% higher rates of opioid cessation, with effects stronger in men.
Clinical study found arthritis patients had significantly lower 2-AG (a key pain-regulating endocannabinoid) and altered inflammatory lipid profiles compared to healthy controls.
A placebo-controlled trial found THC caused pupil constriction (not dilation) and dampened the pupillary light reflex for at least 5 hours in cannabis-naive volunteers.
A survey of 8,521 German teens found those who both smoke and vape perceive cannabis as least harmful and are most likely to intend to use it, while never-tobacco-users perceive the most risk.
EFSA determined delta-8-THC is equally potent to delta-9-THC and set a combined safety limit of 1 microgram/kg body weight, finding many food products contain above-natural delta-8 levels.
Among 1,300 U.S. adults who drink and smoke tobacco, 67% use both simultaneously, 56% also use cannabis, and over 40% combine tobacco and cannabis in the same session.
PET imaging of 62 participants found CB1 receptor availability was not different in PTSD overall but was significantly linked to emotional numbing symptoms, suggesting a specific endocannabinoid role.
JAMA study of 245 teens in a pain clinic found 25% used cannabis, with 77% using it to self-treat pain, sleep, or anxiety. Users had higher pain interference and depression scores.
Mouse study found THC diverts placental stem cell development away from nutrient-exchange cells through CB1 receptor signaling, providing a mechanism for cannabis-related pregnancy complications.
A 10-year study of 320 first-episode psychosis patients found that most immune markers only predicted outcomes in cannabis users, suggesting inflammation and cannabis interact in shaping psychosis trajectories.
A review finds prenatal cannabis exposure affects multiple organ systems beyond neurodevelopment, including cardiovascular, metabolic, and growth outcomes.
A nationally representative survey found 26% of medical and 21% of recreational past-month cannabis users met CUD criteria, with daily users reaching 31-32%.
In mouse meningeal preparations, anandamide showed stronger suppression of pain-related firing than 2-AG, pointing to FAAH inhibition as a migraine target.
A two-week self-guided online intervention helped 69% of cannabis users meet reduction goals, vs. 49% in the control group.
A German survey of 702 CBD users found 38% self-medicate for sleep, pain, depression, and anxiety, with older and unemployed individuals most likely.
In mice, FAAH inhibition reduced anxiety while CB1 blockade and CB2 manipulation increased it.
CBG relaxes human pulmonary arteries through endothelium-dependent mechanisms, modified by hypertension and high cholesterol.
A survey of 26,458 US workers found 7.4% used cannabis at or near work, with highest rates in legal states, high-risk jobs, and among medical cardholders.
Five years post-legalization in Canada, overall driving after cannabis use rose, but among consumers specifically, it slightly declined.
4F-MDMB-BUTICA caused mortality, deformities, behavioral changes, and gene expression alterations in zebrafish embryos.
Fetal brain THC reaches 35-50% of maternal blood. A model predicts 3.7 nM THC from 10mg inhaled.
A double-blind crossover trial found alpha-pinene at three doses did not counteract any THC effects in 19 adults.
Treatment-seeking adolescents used multiple cannabis products including delta-8 and delta-10 THC.
CBD raised anandamide but this did not correlate with blood pressure reduction in 66 hypertensive patients.
Cannabis purchase task measures predicted young adult use frequency three months later.
A review found insufficient evidence for cannabis in PTSD treatment, while Polish medical marijuana clinic websites marketed it aggressively as a therapy.
Of five cannabinoids tested against MRSA biofilms, CBN was most effective at reducing biomass and viability, while each cannabinoid showed a different mechanism of action.
A 28-day daily diary study found cannabis use days were associated with slightly more physical activity, more drinking, and more cigarette smoking.
Vaped THC promoted Candida albicans growth, biofilm formation, and virulence gene expression in a dose-dependent manner in vitro.
A meta-analysis of 47 longitudinal studies identified cannabis use as a novel risk factor for violence in psychosis (OR=3.34), comparable to criminal history (OR=3.50).
A systematic review of 42 studies found high-potency cannabis may be linked to problem use, but evidence was "very low" certainty across all health domains examined.
A survey of 93 IBD patients found 54% used cannabis, with over 50% reporting symptom relief and 19% reducing opioid use.
GDNF brain injection in cannabis-addicted rats reduced anxiety, reversed sperm morphology damage, decreased DNA damage, and improved sperm viability.
In a smoking cessation trial, 47% of participants also used cannabis and increased their cannabis consumption while reducing cigarettes at similar rates to non-users.
A review found cannabis use in people with HIV is associated with reduced inflammation, improved gut health, and unique microbiome changes, though HIV reservoir effects remain unclear.
A survey of 24 pediatric cancer patients in a medical cannabis program found most reported symptom relief for nausea, appetite, and pain with minimal side effects.
A 9-year LA study found most young cannabis users were "Uncontrolled," but harm-reduction rules like avoiding use at work and while driving increased after legalization.
In a Kaiser prenatal program, 80% of 20,398 cannabis-positive pregnancies completed assessment and 88% of those needing help attended counseling.
CBD nanoparticles restored gut barrier function, reduced inflammation, and normalized metabolites in stressed rats, performing comparably to standard antidepressants.
Analysis of 130 cannabinoid-related seizure reports found 68% of individuals had pre-existing risk factors, with drug interactions the most common contributor.
Pain clinic patients with nerve pain used THC/CBD products more frequently than those with other pain types—possibly reflecting a gap in conventional treatment.
CBD and its metabolites reduced human neural stem cell viability at clinically relevant concentrations and altered differentiation markers, raising prenatal safety concerns.
After legalizing private cannabis use, South Africa faces the challenge of workplace testing—this paper proposes impairment-based THC thresholds over zero-tolerance approaches.
A review finds significant species differences in cannabinoid receptor distribution that may explain why animal cannabinoid pain studies fail to translate to human clinical trials.
An fMRI study found daily cannabis users had normal brain value signals for cannabis but disrupted signals for food rewards, supporting reward-narrowing theories of addiction.
A 10-year study of 3,299 people with HIV found 26% were consistently high cannabis users, associated with depression, tobacco use, and older age.
Youth cannabis use slightly decreased after Canadian legalization (15% to 12.3%), but risk factor profiles shifted toward anxiety and mental health indicators.
US national survey data found adults with HIV are 3.35x more likely to co-use tobacco and cannabis, with associations modified by race and state cannabis laws.