Chronic pain patients who use cannabis more frequently show weaker emotion regulation abilities
Among people on long-term opioid therapy for chronic pain, those with weaker ability to regulate emotions (measured by skin conductance and facial muscle responses) used cannabis more frequently, while pain severity itself was not linked to cannabis use.
Quick Facts
What This Study Found
Smaller reductions in skin conductance and corrugator muscle activity during emotion regulation tasks were associated with more days of cannabis use over 90 days. Pain severity was not significantly associated with cannabis use frequency.
Key Numbers
Weaker skin conductance reduction during emotion regulation: beta = -0.018, p < 0.001. Weaker corrugator EMG reduction: beta = -9.59, p < 0.001. Pain severity and cannabis use: beta = 0.026, p = 0.370 (not significant). Sample: 104 participants, mean age 51.12 years.
How They Did This
Researchers analyzed data from 104 participants (mean age 51, 68% female, 89% White) receiving long-term opioid therapy for chronic pain. Cannabis use was measured as days used over 90 days. Emotion regulation was assessed via psychophysiological measures during passive viewing vs. cognitive reappraisal of negative images.
Why This Research Matters
Many chronic pain patients report using cannabis to manage pain, but this study suggests the primary driver may actually be emotional distress rather than physical pain. If true, this shifts the conversation about why pain patients use cannabis and what interventions might help.
The Bigger Picture
The disconnect between pain severity and cannabis use frequency challenges the common assumption that pain patients use cannabis primarily for analgesia. If emotion regulation deficits are the stronger predictor, targeted psychological interventions like mindfulness-based approaches might reduce problematic cannabis use more effectively than simply addressing pain.
What This Study Doesn't Tell Us
Cross-sectional design means causality cannot be determined: it is unclear whether poor emotion regulation leads to more cannabis use or vice versa. The sample was 89% White and predominantly female, limiting generalizability. Self-reported cannabis use days may be imprecise.
Questions This Raises
- ?Does cannabis use worsen emotion regulation capacity over time, or do people with pre-existing deficits gravitate toward cannabis?
- ?Would emotion regulation training reduce cannabis use in this population?
- ?Do these findings hold for chronic pain patients not on opioids?
Trust & Context
- Key Stat:
- Pain severity was not significantly linked to cannabis use frequency (p = 0.370)
- Evidence Grade:
- Small cross-sectional study with 104 participants using objective psychophysiological measures, but cannot establish causality.
- Study Age:
- Published in 2025.
- Original Title:
- Cannabis use frequency is associated with emotion dysregulation among persons receiving long-term opioid therapy for chronic pain: A psychophysiological study.
- Published In:
- Drug and alcohol dependence, 275, 112812 (2025)
- Authors:
- De Aquino, Joao P(12), Costa, Gabriel P A(4), Nunes, Julio C(3), Hudak, Justin, Odette, Madeleine, Garland, Eric L
- Database ID:
- RTHC-06310
Evidence Hierarchy
A snapshot of a population at one point in time.
What do these levels mean? →Frequently Asked Questions
Does this mean cannabis doesn't help with pain?
Not necessarily. The study found that among people already on opioids for pain, those who used cannabis more frequently had weaker emotion regulation rather than worse pain. It suggests emotion management may be a bigger motivator than pain relief for frequent cannabis use in this group.
How was emotion regulation measured?
Using physiological responses: skin conductance (sweating) and corrugator muscle activity (furrowing the brow) while participants tried to reappraise negative images. Smaller changes during reappraisal indicated weaker emotion regulation.
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Cite This Study
https://rethinkthc.com/research/RTHC-06310APA
De Aquino, Joao P; Costa, Gabriel P A; Nunes, Julio C; Hudak, Justin; Odette, Madeleine; Garland, Eric L. (2025). Cannabis use frequency is associated with emotion dysregulation among persons receiving long-term opioid therapy for chronic pain: A psychophysiological study.. Drug and alcohol dependence, 275, 112812. https://doi.org/10.1016/j.drugalcdep.2025.112812
MLA
De Aquino, Joao P, et al. "Cannabis use frequency is associated with emotion dysregulation among persons receiving long-term opioid therapy for chronic pain: A psychophysiological study.." Drug and alcohol dependence, 2025. https://doi.org/10.1016/j.drugalcdep.2025.112812
RethinkTHC
RethinkTHC Research Database. "Cannabis use frequency is associated with emotion dysregulat..." RTHC-06310. Retrieved from https://rethinkthc.com/research/de-2025-cannabis-use-frequency-is
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.