Chronic pain patients who use cannabis more frequently show weaker emotion regulation abilities

Among people on long-term opioid therapy for chronic pain, those with weaker ability to regulate emotions (measured by skin conductance and facial muscle responses) used cannabis more frequently, while pain severity itself was not linked to cannabis use.

De Aquino, Joao P et al.·Drug and alcohol dependence·2025·Preliminary EvidenceCross-Sectional
RTHC-06310Cross SectionalPreliminary Evidence2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Cross-Sectional
Evidence
Preliminary Evidence
Sample
N=104

What This Study Found

Smaller reductions in skin conductance and corrugator muscle activity during emotion regulation tasks were associated with more days of cannabis use over 90 days. Pain severity was not significantly associated with cannabis use frequency.

Key Numbers

Weaker skin conductance reduction during emotion regulation: beta = -0.018, p < 0.001. Weaker corrugator EMG reduction: beta = -9.59, p < 0.001. Pain severity and cannabis use: beta = 0.026, p = 0.370 (not significant). Sample: 104 participants, mean age 51.12 years.

How They Did This

Researchers analyzed data from 104 participants (mean age 51, 68% female, 89% White) receiving long-term opioid therapy for chronic pain. Cannabis use was measured as days used over 90 days. Emotion regulation was assessed via psychophysiological measures during passive viewing vs. cognitive reappraisal of negative images.

Why This Research Matters

Many chronic pain patients report using cannabis to manage pain, but this study suggests the primary driver may actually be emotional distress rather than physical pain. If true, this shifts the conversation about why pain patients use cannabis and what interventions might help.

The Bigger Picture

The disconnect between pain severity and cannabis use frequency challenges the common assumption that pain patients use cannabis primarily for analgesia. If emotion regulation deficits are the stronger predictor, targeted psychological interventions like mindfulness-based approaches might reduce problematic cannabis use more effectively than simply addressing pain.

What This Study Doesn't Tell Us

Cross-sectional design means causality cannot be determined: it is unclear whether poor emotion regulation leads to more cannabis use or vice versa. The sample was 89% White and predominantly female, limiting generalizability. Self-reported cannabis use days may be imprecise.

Questions This Raises

  • ?Does cannabis use worsen emotion regulation capacity over time, or do people with pre-existing deficits gravitate toward cannabis?
  • ?Would emotion regulation training reduce cannabis use in this population?
  • ?Do these findings hold for chronic pain patients not on opioids?

Trust & Context

Key Stat:
Pain severity was not significantly linked to cannabis use frequency (p = 0.370)
Evidence Grade:
Small cross-sectional study with 104 participants using objective psychophysiological measures, but cannot establish causality.
Study Age:
Published in 2025.
Original Title:
Cannabis use frequency is associated with emotion dysregulation among persons receiving long-term opioid therapy for chronic pain: A psychophysiological study.
Published In:
Drug and alcohol dependence, 275, 112812 (2025)
Database ID:
RTHC-06310

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study

A snapshot of a population at one point in time.

What do these levels mean? →

Frequently Asked Questions

Does this mean cannabis doesn't help with pain?

Not necessarily. The study found that among people already on opioids for pain, those who used cannabis more frequently had weaker emotion regulation rather than worse pain. It suggests emotion management may be a bigger motivator than pain relief for frequent cannabis use in this group.

How was emotion regulation measured?

Using physiological responses: skin conductance (sweating) and corrugator muscle activity (furrowing the brow) while participants tried to reappraise negative images. Smaller changes during reappraisal indicated weaker emotion regulation.

Read More on RethinkTHC

Cite This Study

RTHC-06310·https://rethinkthc.com/research/RTHC-06310

APA

De Aquino, Joao P; Costa, Gabriel P A; Nunes, Julio C; Hudak, Justin; Odette, Madeleine; Garland, Eric L. (2025). Cannabis use frequency is associated with emotion dysregulation among persons receiving long-term opioid therapy for chronic pain: A psychophysiological study.. Drug and alcohol dependence, 275, 112812. https://doi.org/10.1016/j.drugalcdep.2025.112812

MLA

De Aquino, Joao P, et al. "Cannabis use frequency is associated with emotion dysregulation among persons receiving long-term opioid therapy for chronic pain: A psychophysiological study.." Drug and alcohol dependence, 2025. https://doi.org/10.1016/j.drugalcdep.2025.112812

RethinkTHC

RethinkTHC Research Database. "Cannabis use frequency is associated with emotion dysregulat..." RTHC-06310. Retrieved from https://rethinkthc.com/research/de-2025-cannabis-use-frequency-is

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.