Cannabis Smoke Combined With Seed Oil Diet Weakened Heart Function and Blocked Inflammation Resolution in Mice
Mice on a seed oil diet exposed to cannabis smoke showed weakened cardiac strain, suppressed anti-inflammatory mediators, and increased immune activation.
Quick Facts
What This Study Found
Cannabis smoke weakened cardiac GLS. CBD and CBC detected in all organs. Anti-inflammatory mediators suppressed. Seed oil diet amplified effects. Lung inflammation observed.
Key Numbers
CBD and CBC in all organs. Anti-inflammatory mediators suppressed. Cardiac GLS weakened. Bronchial thickening.
How They Did This
Mice fed control or safflower oil diet for 4 months, exposed to cannabis smoke for 5 days. Lipid mediators, immune cells, and cardiac function measured.
Why This Research Matters
Cannabis smoking on top of omega-6-rich processed food diets may impair inflammation resolution with cardiac and pulmonary consequences.
The Bigger Picture
The standard American diet may amplify cannabis's negative effects, meaning real-world risks may exceed controlled study predictions.
What This Study Doesn't Tell Us
Mouse model. Male only. Short exposure. Extreme dietary model.
Questions This Raises
- ?Would non-smoked cannabis have the same effects?
- ?Does diet modify cannabis cardiovascular risk in humans?
Trust & Context
- Key Stat:
- Evidence Grade:
- Multi-organ analysis but short duration and extreme dietary model.
- Study Age:
- 2025 preclinical study.
- Original Title:
- Cannabis cigarette smoking disrupts mice multi-organ bioactive lipid metabolism and inflammation-resolution signaling in an obesogenic setting.
- Published In:
- Life sciences, 383, 124076 (2025)
- Authors:
- Upadhyay, Gunjan, Duong, Long, Kain, Vasundhara, Ghobrial, Megan, Marimuthu, Mathan Kumar, Fouad, Alexadra, Yeatman, Timothy J, Herazo-Maya, Jose D, Halade, Ganesh V
- Database ID:
- RTHC-07839
Evidence Hierarchy
Frequently Asked Questions
Does cannabis smoking affect the heart?
In mice, it weakened cardiac strain and suppressed anti-inflammatory mediators, especially with a seed oil diet.
Does diet affect cannabis health impacts?
Yes. Seed oil-fed mice had worse outcomes from cannabis smoke.
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Cite This Study
https://rethinkthc.com/research/RTHC-07839APA
Upadhyay, Gunjan; Duong, Long; Kain, Vasundhara; Ghobrial, Megan; Marimuthu, Mathan Kumar; Fouad, Alexadra; Yeatman, Timothy J; Herazo-Maya, Jose D; Halade, Ganesh V. (2025). Cannabis cigarette smoking disrupts mice multi-organ bioactive lipid metabolism and inflammation-resolution signaling in an obesogenic setting.. Life sciences, 383, 124076. https://doi.org/10.1016/j.lfs.2025.124076
MLA
Upadhyay, Gunjan, et al. "Cannabis cigarette smoking disrupts mice multi-organ bioactive lipid metabolism and inflammation-resolution signaling in an obesogenic setting.." Life sciences, 2025. https://doi.org/10.1016/j.lfs.2025.124076
RethinkTHC
RethinkTHC Research Database. "Cannabis cigarette smoking disrupts mice multi-organ bioacti..." RTHC-07839. Retrieved from https://rethinkthc.com/research/upadhyay-2025-cannabis-cigarette-smoking-disrupts
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.