Mice on a seed oil diet exposed to cannabis smoke showed weakened cardiac strain, suppressed anti-inflammatory mediators, and increased immune activation.
Cardiovascular researchers, cannabis users, and nutritional immunologists.
What the researchers found
Cannabis smoke weakened cardiac GLS. CBD and CBC detected in all organs. Anti-inflammatory mediators suppressed. Seed oil diet amplified effects. Lung inflammation observed.
Why it matters
Cannabis smoking on top of omega-6-rich processed food diets may impair inflammation resolution with cardiac and pulmonary consequences.
The numbers in context
CBD and CBC in all organs. Anti-inflammatory mediators suppressed. Cardiac GLS weakened. Bronchial thickening.
How the study worked
Mice fed control or safflower oil diet for 4 months, exposed to cannabis smoke for 5 days. Lipid mediators, immune cells, and cardiac function measured.
What this study cannot tell us
Mouse model. Male only. Short exposure. Extreme dietary model.
How to read the evidence
Multi-organ analysis but short duration and extreme dietary model.
When this study was published
2025 preclinical study.
The bigger picture
The standard American diet may amplify cannabis's negative effects, meaning real-world risks may exceed controlled study predictions.
Questions still open
- Would non-smoked cannabis have the same effects?
- Does diet modify cannabis cardiovascular risk in humans?
Common questions
Does cannabis smoking affect the heart?
Does diet affect cannabis health impacts?
Read the original research
Cannabis cigarette smoking disrupts mice multi-organ bioactive lipid metabolism and inflammation-resolution signaling in an obesogenic setting.
Life sciences, 383, 124076
Citation
Upadhyay, Gunjan; Duong, Long; Kain, Vasundhara; Ghobrial, Megan; Marimuthu, Mathan Kumar; Fouad, Alexadra; Yeatman, Timothy J; Herazo-Maya, Jose D; Halade, Ganesh V. (2025). Cannabis cigarette smoking disrupts mice multi-organ bioactive lipid metabolism and inflammation-resolution signaling in an obesogenic setting.. Life sciences, 383, 124076. https://doi.org/10.1016/j.lfs.2025.124076
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