In a small pilot trial, the Alzheimer's drug galantamine was safe and well-tolerated in people with cannabis use disorder, but did not improve cognition beyond what was seen with placebo.
Researchers studying cannabis use disorder treatments and people interested in cognitive effects of cannabis.
30 participants, no significant treatment effect
What the researchers found
Both the galantamine and placebo groups showed modest improvements in response inhibition and attention over 10 days. Cannabis withdrawal and craving decreased over time in both groups. No significant treatment effect or treatment-by-time interaction was found for galantamine versus placebo.
Why it matters
As cannabis use and THC concentrations increase, finding ways to counteract cognitive effects becomes more relevant. This pilot establishes that galantamine is at least safe in this population.
The numbers in context
30 participants (73.5% male, 26.5% female). 8 mg/day galantamine dose. 10-day treatment period. 3 cognitive assessments. 6 time points for self-reported measures.
How the study worked
Randomized, double-blind, parallel-group trial with 30 participants with cannabis use disorder. Participants received either 8 mg/day galantamine or placebo for 10 days, with cognitive assessments at three time points.
What this study cannot tell us
Very small sample size (30 participants). Short treatment duration (10 days). The 8 mg/day dose was the lowest therapeutic dose, and higher doses might produce different results. No acute cannabis intoxication was tested.
How to read the evidence
Randomized controlled design, but underpowered pilot study with very small sample.
When this study was published
2019 pilot study.
The bigger picture
Cognitive concerns are among the most commonly cited reasons people seek treatment for cannabis use disorder. If a medication could address cognitive effects, it might support recovery efforts.
Questions still open
- Would higher galantamine doses or longer treatment produce cognitive benefits? Would the drug help during acute cannabis intoxication rather than during abstinence?
Common questions
Can galantamine help with cannabis-related cognitive problems?
Did cannabis craving decrease in the study?
Read the original research
Feasibility and effects of galantamine on cognition in humans with cannabis use disorder.
Pharmacology, biochemistry, and behavior, 181, 86-92
Citation
Sugarman, Dawn E; De Aquino, Joao P; Poling, James; Sofuoglu, Mehmet. (2019). Feasibility and effects of galantamine on cognition in humans with cannabis use disorder.. Pharmacology, biochemistry, and behavior, 181, 86-92. https://doi.org/10.1016/j.pbb.2019.05.004
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