Attentional bias training did not improve outcomes for alcohol or cannabis use disorder

A multicenter RCT of 169 participants found that an internet-based attentional bias modification program added to standard treatment produced no significant improvements in substance use, craving, or relapse rates.

Heitmann, Janika et al.·PloS one·2021·Moderate EvidenceRandomized Controlled Trial
RTHC-03196Randomized Controlled TrialModerate Evidence2021RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Randomized Controlled Trial
Evidence
Moderate Evidence
Sample
N=169

What This Study Found

No significant differences emerged between the ABM group and control groups on any measure: substance use, craving, relapse rates, attentional bias, depression, anxiety, or stress, either at post-test or at 6- and 12-month follow-ups. The null results held across all time points.

Key Numbers

169 participants: 50% ABM+TAU, 25% placebo+TAU, 25% TAU only. No significant differences on any outcome at any time point. Measures included substance use, craving, relapse, attentional bias, depression, anxiety, and stress.

How They Did This

Multicenter RCT with 169 participants diagnosed with alcohol or cannabis use disorder. Randomly assigned to treatment as usual (TAU) plus attentional bias modification (ABM), TAU plus placebo training, or TAU only. The ABM used a home-delivered, multi-session internet program called the Bouncing Image Training Task. Outcomes assessed at baseline, post-test, 6 months, and 12 months.

Why This Research Matters

Attentional bias (automatic attention toward substance-related cues) has been theorized as a key mechanism in addiction persistence. This well-designed trial found no support for ABM as an add-on treatment, raising questions about whether targeting attention is the right approach.

The Bigger Picture

The failure of ABM to improve addiction outcomes adds to growing skepticism about attentional bias interventions outside the lab. The results may reflect that real-world addiction is driven by factors far more powerful than automatic attentional patterns, or that the specific intervention did not successfully modify bias.

What This Study Doesn't Tell Us

Mixed treatment goals (some pursuing moderation, others abstinence) may have diluted effects. The specific ABM task may not have targeted the right attentional process (engagement vs. disengagement). Home-based delivery reduces compliance monitoring.

Questions This Raises

  • ?Would ABM work if it targeted disengagement rather than engagement bias?
  • ?Does the mixed treatment goal of the sample explain the null results?
  • ?Is attentional bias even a modifiable treatment target in real-world addiction?

Trust & Context

Key Stat:
No significant differences on any outcome at any time point
Evidence Grade:
Well-designed multicenter RCT with long follow-up. Null results are clearly negative rather than inconclusive due to the comprehensive outcome assessment.
Study Age:
2021 multicenter RCT from the Netherlands.
Original Title:
Effectiveness of attentional bias modification training as add-on to regular treatment in alcohol and cannabis use disorder: A multicenter randomized control trial.
Published In:
PloS one, 16(6), e0252494 (2021)
Database ID:
RTHC-03196

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled TrialGold standard for testing treatments
This study
Cohort / Case-Control
Cross-Sectional / Observational
Case Report / Animal Study

Participants are randomly assigned to treatment or placebo groups to test cause and effect.

What do these levels mean? →

Frequently Asked Questions

What is attentional bias modification?

It is a computer-based training designed to reduce automatic attention toward substance-related cues (like images of alcohol or cannabis). The theory is that this automatic attention helps maintain addiction.

Why might the training have failed?

The authors suggest three possibilities: the training may not have successfully changed attentional bias, it may have targeted the wrong attentional process, or the mixed treatment goals of participants may have reduced effectiveness.

Read More on RethinkTHC

Cite This Study

RTHC-03196·https://rethinkthc.com/research/RTHC-03196

APA

Heitmann, Janika; van Hemel-Ruiter, Madelon E; Huisman, Mark; Ostafin, Brian D; Wiers, Reinout W; MacLeod, Colin; DeFuentes-Merillas, Laura; Fledderus, Martine; Markus, Wiebren; de Jong, Peter J. (2021). Effectiveness of attentional bias modification training as add-on to regular treatment in alcohol and cannabis use disorder: A multicenter randomized control trial.. PloS one, 16(6), e0252494. https://doi.org/10.1371/journal.pone.0252494

MLA

Heitmann, Janika, et al. "Effectiveness of attentional bias modification training as add-on to regular treatment in alcohol and cannabis use disorder: A multicenter randomized control trial.." PloS one, 2021. https://doi.org/10.1371/journal.pone.0252494

RethinkTHC

RethinkTHC Research Database. "Effectiveness of attentional bias modification training as a..." RTHC-03196. Retrieved from https://rethinkthc.com/research/heitmann-2021-effectiveness-of-attentional-bias

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.